Organic Chemistry with a Biological Emphasis Volume I

Format:

Book

Author/Creator:

Soderberg, Tim, author.

Language:

English

Subjects (All):

Science--Textbooks.

Science.

Chemistry--Textbooks.

Chemistry.

Physical Description:

1 online resource

Place of Publication:

Morris, Minnesota University of Minnesota Morris [2016]

Language Note:

In English.

Summary:

The traditional approach to teaching Organic Chemistry, taken by most of the textbooks that are currently available, is to focus primarily on the reactions of laboratory synthesis, with much less discussion - in the central chapters, at least - of biological molecules and reactions. This is despite the fact that, in many classrooms, a majority of students are majoring in Biology or Health Sciences rather than in Chemistry, and are presumably taking the course in order to learn about the chemistry that takes place in living things.In an effort to address this disconnect, I have developed a textbook for a two-semester, sophomore-level course in Organic Chemistry in which biological chemistry takes center stage. For the most part, the text covers the core concepts of organic structure, structure determination, and reactivity in the standard order. What is different is the context: biological chemistry is fully integrated into the explanation of central principles, and as much as possible the in-chapter and end-of-chapter problems are taken from the biochemical literature. Many laboratory synthesis reactions are also covered, generally in parallel with their biochemical counterparts - but it is intentionally the biological chemistry that comes first.

Contents:

Chapter 1: Introduction to organic structure and bonding, part I

Section 1: Drawing organic structures

Section 2: Functional groups and organic nomenclature

Section 3: Structures of some important classes of biological molecules

Chapter 2: Introduction to organic structure and bonding, part II

Section 1: Covalent bonding in organic molecules

Section 2: Molecular orbital theory

Section 3: Resonance

Section 4: Non-covalent interactions

Section 5: Physical properties of organic compounds

Chapter 3: Conformation and Stereochemistry

Section 1: Conformations of open-chain organic molecules

Section 2: Conformations of cyclic organic molecules

Section 3: Chirality and stereoisomers

Section 4: Labeling chiral centers

Section 5: Optical activity

Section 6: Compounds with multiple chiral centers

Section 7: Meso compounds

Section 8: Fischer and Haworth projections

Section 9: Stereochemistry of alkenes

Section 10: Stereochemistry in biology and medicine

Section 11: Prochirality

Chapter 4: Structure determination part I - Infrared spectroscopy, UV-visible spectroscopy, and mass spectrometry

Section 1: Mass Spectrometry

Section 2: Introduction to molecular spectroscopy

Section 3: Infrared spectroscopy

Section 4: Ultraviolet and visible spectroscopy

Chapter 5: Structure determination part II - Nuclear magnetic resonancespectroscopy

Section 1: The origin of the NMR signal

Section 2: Chemical equivalence

Section 3: The 1H-NMR experiment

Section 4: The basis for differences in chemical shift

Section 5: Spin-spin coupling

Section 6: 13C-NMR spectroscopy

Section 7: Solving unknown structures

Section 8: Complex coupling in 1H-NMR spectra

Section 9: Other applications of NMR

Chapter 6: Overview of organic reactivity

Section 1: A first look at some organic reaction mechanisms

Section 2: A quick review of thermodynamics and kinetics

Section 3: Catalysis

Section 4: Comparing biological reactions to laboratory reactions

Chapter 7: Acid-base reactions

Section 1: Acid-base reactions

Section 2: Comparing the acidity and basicity of organic functional groups– the acidityconstant

Section 3: Structural effects on acidity and basicity

Section 4: Acid-base properties of phenols

Section 5: Acid-base properties of nitrogen-containing functional groups

Section 6: Carbon acids

Section 7: Polyprotic acids

Section 8: Effects of enzyme microenvironment on acidity and basicity

Chapter 8: Nucleophilic substitution reactions

Section 1: Two mechanistic models for nucleophilic substitution

Section 2: Nucleophiles

Section 3: Electrophiles

Section 4: Leaving groups

Section 5: SN1 reactions with allylic electrophiles

Section 6: SN1 or SN2? Predicting the mechanism

Section 7: Biological nucleophilic substitution reactions

Section 8: Nucleophilic substitution in the lab

Notes:

CC BY-SA

Description based on online resource

OCLC:

1000381880