Sustainability in TIDES Chemistry : Green Approaches to Oligonucleotides and Oligopeptides Synthesis / edited by Alessandra Tolomelli, Lucia Ferrazzano, and Walter Cabri.

Format:

Book

Contributor:

Tolomelli, Alessandra, editor.

Ferrazzano, Lucia, editor.

Cabri, Walter, editor.

Series:

Green chemistry series ; Volume 85.

Green Chemistry Series ; Volume 85

Language:

English

Subjects (All):

Biochemistry.

Chemistry.

Green chemistry.

Oligonucleotides.

Physical Description:

1 online resource (425 pages)

Edition:

First edition.

Place of Publication:

London : Royal Society of Chemistry, [2024]

Summary:

Bringing together the information on green synthesis of oligopeptides and the preliminary data on green oligonucleotides synthesis, this book bridges the gap between these two areas.

Contents:

Cover

Sustainability in TIDES Chemistry: Green Approaches to Oligonucleotides and Oligopeptides Synthesis

Foreword

Preface

Contents

1 - Introduction

1.1 Introduction

1.2 Chapter Summaries

1.3 Conclusion

References

2 - Green Metrics for a Sustainable Approach in Iterative Processes

2.1 Introduction

2.2 Carbon Footprint

2.3 Green Metrics and Molecule Classes

2.4 Reaction Mass Efficiency (RME)

2.5 Process Mass Intensity (PMI)

2.6 Process Mass Intensity with Recovery (PMIr)

2.7 From Kilograms to Large Production Volumes

2.8 Conclusions

3 - Recent Trends in Peptide Drug Discovery and Development

3.1 Introduction

3.2 Peptide Drug Development Based on Peptide Hormones

3.2.1 Insulin Drug Development – Setting the Scene for Peptide Drug Development and Company Growth

3.2.2 GLP-1 Drug Development – A New Era for Treating Diabetes, Obesity, and Cardiovascular Disorders

3.2.3 Dual GLP-1R/GIPR/GCGR Agonists – The Next Generation of Type 2 Diabetes and Obesity Treatments

3.2.4 Melanocyte-stimulating Hormone Analogues – Treatments for an Array of Metabolic and Endocrine Disorders

3.2.5 Natriuretic Peptides Analogues – From Cardiovascular System to Rare Disease Treatment

3.3 Nature-derived Peptide Drugs – A Reliable and Vast Source of Therapeutic Leads

3.4 Display Library-derived Peptide Drugs – A New Era of Directed Evolution-driven Discovery Generated by AI.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

Description based on print version record.

Includes bibliographical references.

ISBN:

9781837674541

183767454X

9781837674558

1837674558