S-heterocycles : retrospect, prospects, and biological applications / edited by Shrikaant Kulkarni [and three others].

Format:

Book

Contributor:

Kulkarni, Shrikaant, editor.

Language:

English

Subjects (All):

Biochemistry.

Chemistry.

Heterocyclic chemistry.

Physical Description:

1 online resource (415 pages)

Edition:

First edition.

Place of Publication:

London, England : The Royal Society of Chemistry, [2024]

Summary:

This edited volume reports the latest developments in practical and selective reactions and methods involving carbenes and nitrenes and provides details of the structural diversity of heterocycles.

Contents:

Cover

Synthesis, Properties, and Biological Applications of 1,3-Thiazoles

1.1 Introduction

1.2 Recent Advances in the Synthesis of Thiazole

1.3 Biological Applications

1.3.1 Thiazole as an Anticancer Agent

1.3.2 Thiazole as an Antioxidant Agent

1.3.3 Thiazole as an Antitubercular Agent

1.3.4 Thiazole as an Antimicrobial Agent

1.4 Conclusion

Abbreviations

References

Synthesis, Properties, and Therapeutic Applications of Dithiazoles

2.1 Introduction

2.2 Synthesis and Chemistry

2.2.1 Reaction at the More Reactive C-5 Position of Appel's Salt

2.2.2 Reaction at the Less Reactive C-4 Position of Appel's Salt

2.2.3 Synthesis of Fused Dithiazoles

2.3 Biological Activity of 1,2,3-Dithiazoles

2.3.1 Antimicrobial Activities of 1,2,3-Dithiazoles

2.3.2 Antiviral Activities of 1,2,3-Dithiazoles

2.3.3 Anticancer Activities of 1,2,3-Dithiazoles

2.3.4 Other Biological Activities

2.4 Conclusion

Isothiazoles: Synthetic Strategies and Pharmacological Applications

3.1 Introduction

3.2 Recent Advances in the Synthesis of Isothiazoles

3.3 Biological Applications

3.3.1 Isothiazole as the Anticancer Agent

3.3.2 Isothiazole as the Antidiabetic Agent

3.3.3 Isothiazole as an Antiviral Agent

3.3.4 Isothiazole with Neurological Activity

3.3.5 Isothiazole as Antimicrobial/Antibacterial/Antifungal Agents

3.3.6 Isothiazole as Fungicides/Pesticides/Plant Protectors

3.4 Conclusion

Synthesis, Properties, and Biological Applications of Benzothiazoles

4.1 Introduction

4.2 Synthesis of Benzothiazoles and Their Derivatives

4.2.1 Synthesis from Isothiocyanates

4.2.2 Synthesis from Triethyl Orthoformate

4.2.3 Synthesis from Aniline Derivatives

4.2.4 Synthesis from Hydrazine.

4.2.5 Intramolecular Formation of C-S Using Pd and Cu Catalysts

4.2.6 Solvent-free Synthesis

4.2.7 Cyclization

4.2.8 One-pot Synthesis of 2-Aminobenzothiazoles

4.2.9 Synthesis by Suzuki-Miyaura

4.2.10 Fused Benzothiazole Synthesis

4.3 Physicochemical Properties of Benzothiazoles

4.4 Biological Activities of Benzothiazoles

4.4.1 Antimicrobial Activity

4.4.2 Anticancer Activity

4.4.3 Anti-inflammatory Effects

4.4.4 Antiviral Activity

4.4.5 Antidiabetic Activity

4.4.6 Antioxidant Activity

4.4.7 Antitubercular Activity

4.5 Emerging Trends and Future Prospects

4.6 Conclusion

Synthesis, Properties, and Biological Applications of 2,4-Thiazolidinediones

5.1 Introduction

5.1.1 Importance of 2,4-Thiazolidinedione Analogues in Medicinal Chemistry

5.2 Recent Advances in Synthesis

5.3 Medicinal Chemistry Applications

5.3.1 Antidiabetic Effects

5.3.2 Anticancer Effects

5.3.3 Anti-inflammatory Effects

5.3.4 Antioxidant Effects

5.4 TZDs and Their Side Effects

5.5 Conclusion

Synthesis, Properties, and Biological Applications of 1,2,4-Thiadiazoles

6.1 Introduction

6.2 Recent Advances in the Synthesis of 1,2,4-Thiadiazoles

6.3 Biological Applications

6.3.1 Anticonvulsant Activity

6.3.2 Anticancer Activity

6.3.3 Central Nervous System Activity

6.3.4 Cathepsin B Inhibitor

6.3.5 Anticholinesterase Activity and Antioxidant Properties

6.3.6 Alzheimer's Disease

6.3.7 Anticonvulsant Activity

6.3.8 Plant Growth Regulator Herbicide

6.4 Conclusion

Acknowledgements

Synthesis, Properties, and Biological Applications of 1,3,4-Thiadiazoles

7.1 Introduction

7.1.1 Isomers of Thiadiazoles

7.1.2 Chemical Properties and Characteristics of 1,3,4-Thiadiazoles.

7.2 Synthesis of 1,3,4-Thiadiazoles

7.2.1 Conventional Methods for the Synthesis of 1,3,4-Thiadiazoles

7.2.2 Green Methods for the Synthesis of 1,3,4-Thiadiazoles

7.3 Applications of 1,3,4-Thiadiazoles in Currently Marketed Drugs/Investigational Compounds

7.4 Biological Activities of 1,3,4-Thiadiazoles

7.4.1 Anti-inflammatory Agents

7.4.2 Anti-diabetic Agents

7.4.3 Anti-seizure/Anti-epileptic/Anti-convulsant Agents

7.4.4 Anti-cancer Agents

7.4.5 Anti-Alzheimer Agents

7.4.6 Anti-viral Agents

7.4.7 Anti-tuberculosis Agents

7.4.8 Antimicrobial Agents

7.4.9 Diuretic Agents

7.4.10 Anti-obesity Agents

7.4.11 Anti-glaucoma Agents

7.4.12 Anti-platelet Agents

7.4.13 Anti-aging Agents

7.4.14 Anti-leishmanicidal Agents

7.4.15 Anti-H. pylori Agents

7.4.16 Anti-fungal Agents

7.5 Patent Updates on 1,3,4-Thiadiazoles

7.6 Ongoing Clinical Trials

Synthesis, Properties, and Biological Applications of Thiopyrans

8.1 Introduction

8.2 Developments in the Synthesis of Thiopyran Derivatives

8.2.1 Synthesis of Thiopyran Derivatives Using Glutaraldehyde Derivatives

8.2.2 Synthesis of Thiopyrans from Thioenolates

8.2.3 Synthesis of Thiopyrans from Thioamides

8.2.4 Hantzsch-like Synthesis of 4H-thiopyrans

8.2.5 Synthesis of Thiopyrans from Acetylenes

8.2.6 Synthesis of Thiopyrans from Enamines

8.2.7 Synthesis of Thiopyrans from Thiopyrylium Salts

8.2.8 Synthesis of Thiopyrans by Reduction

8.2.9 Synthesis of Thiopyrans by Reactions with C-nucleophiles and Reductive C-substitutions

8.2.10 Reactions with Oxygen and Sulfur Nucleophiles

8.2.11 Synthesis of Thiopyrans by Reactions with Nitrogen and Phosphorus Nucleophiles

8.2.12 Synthesis of Thiopyrans from Thiopyrones and Similar Cyclic Ketones

8.2.13 Synthesis of Thiopyrans from Thiophenes.

8.2.14 Synthesis of Thiopyrans from 1,5-Diketones

8.2.15 Synthesis of Thiopyrans by Electrosynthesis and with Catalysts

8.2.16 Synthesis of Thiopyrans from β-Keto Esters

8.2.17 Synthesis of Thiopyrans from N-methylisatin

8.2.18 Synthesis of Thiopyrans by Intramolecular Coupling

8.3 Pharmacological Profile of Thiopyran Derivatives

8.3.1 Antibacterial and Antifungal Activities

8.3.2 Anticancer Activity

8.3.3 Antiviral Activity

8.3.4 VEGFR-2 Inhibitory Activity

8.3.5 5-LOX Inhibitory Activity

8.3.6 Larvicidal Activity

8.3.7 Nematicidal Activity

8.3.8 Anti-inflammatory Activity

8.3.9 Hypoglycemic Activity

8.4 Conclusion

Recent Developments in the Synthesis and Biological Applications of Thiazine

9.1 Introduction

9.2 Recent Advances in the Synthesis of Thiazine

9.3 Biological Applications

9.3.1 Thiazine as Anticancer Agents

9.3.2 Thiazine as Antimicrobial Agents

9.3.3 Thiazine as Antitubercular Agents

9.3.4 Thiazine as Anticonvulsant Agents

9.3.5 Thiazine as Antihypertensive Agents

9.3.6 Thiazine as Miscellaneous Agents

9.4 Conclusions

Synthesis, Properties, and Biological Applications of Benzothiazepines

10.1 Introduction

10.2 Synthetic Approaches for Benzothiazepine

10.3 Synthesis of 1,4-Benzothiazepine

10.3.1 Synthesis of 4,1-Benzothiazepine-4-oxide 10.3.29

10.3.2 Synthesis of 4,1-Benzothiazepine-4,4-dioxide 10.3.30

10.3.3 Synthesis of 1,5-Dihydro-4,1-benzothiazepine Derivatives 10.3.31

10.3.4 Reaction Mechanism

10.3.5 Synthesis of 2,3,4,5-Tetrahydrobenzo[1,4]thiazepines via N-Acyliminium Cyclization36

10.3.6 Synthesis of Phosphonomethylbenzothiazepine29

10.3.7 Asymmetric Reduction of 10.3.45 and Conversion into ASBT Inhibitor 10.3.48

10.3.8 Synthesis of 1,4-Benzothiazepines from Cyclic Sulfenamides37.

10.3.9 Synthesis of 1,4-Benzothiazepine using Cysteine38

10.3.10 Synthesis of Bicyclic 1,4-Benzothiazepines39

10.4 Biological Behavior of 1,4-Benzothiazepines

10.4.1 Anti-tumor potential

10.4.2 Anti-malarial potential

10.4.3 Anti-bacterial potential

10.4.4 Anti-fungal potential

10.4.5 Anti-diabetic Potential

10.4.6 Antioxidant Potential

10.4.7 Analgesic and Anti-inflammatory Potential

10.4.8 Anti-convulsant Potential

10.4.9 Other Biological Potentials

10.5 Structure-Activity Relationship Study

10.6 Conclusion

Synthesis, Properties, and Biological Applications of Thiophene

11.1 Introduction

11.2 Recent Developments in the Synthesis of Thiophene Derivatives

11.2.1 Synthesis of Thiophene Derivatives Through Metal-catalyzed Reaction

11.2.2 Synthesis of Thiophene Derivatives Through Iodocyclization Reaction

11.2.3 Synthesis of Thiophene Derivatives Through Metal-free Approaches

11.2.4 Synthesis of Thiophene Derivatives Through Multicomponent Reaction Approaches

11.3 Recent Advances in Biological Applications of Thiophene Derivatives

11.3.1 Antimicrobial Activity of Thiophene Derivatives

11.3.2 Antileishmanial Activity of Thiophene Derivatives

11.3.3 Antiviral Activity of Thiophene Derivatives

11.3.4 Anticancer Activity of Thiophene Derivatives

11.3.5 Anti-inflammatory Activity of Thiophene Derivatives

11.3.6 Anticonvulsant and Antiurease Activity of Thiophene Derivatives

11.3.7 Antioxidant, Enzyme Inhibition, and Antithrombotic Activity of Thiophene Derivatives

Synthesis, Properties, and Biological Applications of Benzothiophene

12.1 Introduction

12.1.1 Physical Properties

12.2 Recent Synthesis

12.2.1 Cyclization Reactions by Lewis Acid

12.2.2 Cyclization Reactions by Halogen Catalysis

12.2.3 Cyclization Reactions by Transition Metal Catalysis.

12.2.4 Cyclization Reactions by Base Catalysis.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9781837674862

1837674868

9781837674855

183767485X