Mid-size Drugs Based on Peptides and Peptidomimetics : A New Drug Category / by Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi.

Format:

Book

Author/Creator:

Tamamura, Hirokazu, author.

Kobayakawa, Takuya, author.

Ohashi, Nami, author.

Contributor:

SpringerLink (Online service)

Series:

SpringerBriefs in pharmaceutical science & drug development 1864-8118

SpringerBriefs in Pharmaceutical Science & Drug Development, 1864-8118

Language:

English

Subjects (All):

Chemistry.

Pharmaceutical technology.

Chemistry, Organic.

Pharmaceutical chemistry.

Medicinal Chemistry.

Pharmaceutical Sciences/Technology.

Organic Chemistry.

Local Subjects:

Chemistry.

Medicinal Chemistry.

Pharmaceutical Sciences/Technology.

Organic Chemistry.

Physical Description:

1 online resource (XVII, 100 pages 40 illustrations, 32 illustrations in color).

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2018.

System Details:

text file PDF

Summary:

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry. .

Contents:

1. Introduction of Mid-Size Drugs and Peptidomimetics

2. Chloroalkene Dipeptide Isosteres as Peptidomimetics

3. Conformational-restricted Cyclic Peptides

4. Peptidomimetics that Mimic Secondary Structures of Peptides

5.Peptidomimetics that Mimic Tertiary Structures of Peptides

6. Conjugated Compounds Involving Peptides

7. Summary and Future Perspectives of Researches on Mid-Size Drugs.

Other Format:

Printed edition:

ISBN:

9789811076916

Access Restriction:

Restricted for use by site license.