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Biomedical Applications of Acridines : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases / by Jan Ježek, Jan Hlaváček, Jaroslav Šebestík.
Levy Dental Medicine Library - Stacks RS122 .F6 v.58-59
Available
LIBRA v.12 (1968)-v.19 (1975)
Available from offsite location
- Format:
- Book
- Author/Creator:
- Ježek, Jan (Organic chemist), author.
- Hlavacek, Jan, 1969- author.
- Šebestík, Jaroslav, author.
- Series:
- Progress in drug research 0071-786X ; 72.
- Progress in Drug Research, 0071-786X ; 72
- Language:
- English
- Subjects (All):
- Chemistry.
- Neurochemistry.
- Pharmacology.
- Bioorganic chemistry.
- Pharmaceutical chemistry.
- Nucleic acids.
- Proteins.
- Local Subjects:
- Chemistry.
- Physical Description:
- 1 online resource.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2017.
- System Details:
- text file PDF
- Summary:
- This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
- Contents:
- Preliminary ToC 1 Introduction
- 2 Nomenclature
- 3. Syntheses
- 4. Interactions of acridines with nucleic acids
- 5. Intercations with proteins
- 6. Applications for treament of neurodegenerative diseases
- 7. Some applications of selective toxicities of acridines
- 8. Acridine on dendrimeric carriers
- 9 Acridines used for staining
- 10 Miscellaneous
- 11 Conclusions and outlook.
- Other Format:
- Printed edition:
- ISBN:
- 9783319639536
- Access Restriction:
- Restricted for use by site license.
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