Engineering Crystallography: From Molecule to Crystal to Functional Form / edited by Kevin J. Roberts, Robert Docherty, Rui Tamura.

Format:

Book

Contributor:

Roberts, Kevin J., editor.

Docherty, Robert, editor.

Tamura, Rui, editor.

SpringerLink (Online service)

Series:

NATO science for peace and security series. Chemistry and biology 1874-6489 Series A,

NATO Science for Peace and Security Series A: Chemistry and Biology, 1874-6489

Language:

English

Subjects (All):

Chemistry.

Pharmaceutical technology.

Chemical engineering.

Local Subjects:

Chemistry.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This book highlights the current state-of-the-art regarding the application of applied crystallographic methodologies for understanding, predicting and controlling the transformation from the molecular to crystalline state with the latter exhibiting pre-defined properties. This philosophy is built around the fundamental principles underpinning the three inter-connected themes of Form (what), Formation (how) and Function (why). Topics covered include: molecular and crystal structure, chirality and ferromagnetism, supramolecular assembly, defects and reactivity, morphology and surface energetics. Approaches for preparing crystals and nano-crystals with novel physical, chemical and mechanical properties include: crystallisation, seeding, phase diagrams, polymorphic control, chiral separation, ultrasonic techniques and mechano-chemistry. The vision is realised through examination of a range of advanced analytical characterisation techniques including in-situ studies. The work is underpinned through an unprecedented structural perspective of molecular features, solid-state packing arrangements and surface energetics as well as in-situ studies. This work will be of interest to researchers, industrialists, intellectual property specialists and policy makers interested in the latest developments in the design and supply of advanced high added-value organic solid-form materials and product composites.

Contents:

Form

1. Crystal Science Fundamentals

Molecular Structure, Chirality and Chiral Crystals

Supramolecular Assembly and Solid State Chemistry

Solid Form Landscape and Design of Physical Properties

Design of Physical Properties and Solid Form Design

Modelling Route Map: from Molecule through the Solution State to Crystals

Crystal Growth and Morphology of Molecular Crystals

Determining Surface Energetics of Solid Surfaces

Crystal Effects Influencing the Course of Organic Solid State Reactions: Perfect, Imperfect and Surface Effects

Synthonic Engineering Modelling Tools for Product and Process Design

Formation

Crystallisation Route Map

Phase Diagrams for Process Design

Seeding in Crystallisation

Preparation, Stabilisation and Advantages of Metastable Polymorphs

Crystallisation Control by Process Analytical Technology

Methods for Nano-Crystals Preparation

Crystallisation Control Approaches and Models

Application of Ultrasound in Crystallization (Sonocrystallization)

Continuous Pharmaceutical Crystallization from Solution

Viedma Ripening and its Role in the Chiral Separation of Optical Isomers

Mechanochemistry and its Role in Novel Crystal Form Discovery

Innovative Spontaneous Chiral Resolution Phenomenon: Preferential Enrichment

Function

Pharmaceutical Solid State Characterisation Techniques

Techniques for Crystal Optical Characterisation: Chiroptical Spectroscopy

Unique Ferromagnetic Properties Observed in All-Organic Radical Liquid Crystals

Mechanical Deformation Chemistry of Crystals: Designing Mechanical Performance

DEM Analysis of the Effects of Die Shape and Orientation on Die Filling Processes

Finite Element Modeling of Powder Compaction

From Molecules to Crystals to Functional Form: Science of Scale.

Other Format:

Printed edition:

ISBN:

9789402411171

Access Restriction:

Restricted for use by site license.