Mechanisms of cerebral hypoxia and stroke / edited by George Somjen.

Format:

Book

Conference/Event

Contributor:

Somjen, George G.

International Brain Research Organization. Congress 1987 : Budapest, Hungary)

Conference Name:

Symposium on Cerebral Hypoxia and Stroke (1987 : Budapest, Hungary)

Series:

Advances in behavioral biology ; v. 35.

Advances in behavioral biology ; v. 35

Language:

English

Subjects (All):

Cerebral ischemia--Pathophysiology--Congresses.

Cerebral ischemia.

Cerebrovascular disease--Pathophysiology--Congresses.

Cerebrovascular disease.

Cerebrovascular Disorders.

Hypoxia, Brain.

Cerebrovascular disease--Pathophysiology.

Cerebral ischemia--Pathophysiology.

Cerebrovascular disorders--Congresses.

Cerebral anoxia--Congresses.

Medical Subjects:

Cerebrovascular Disorders.

Hypoxia, Brain.

Local Subjects:

Cerebrovascular disorders--Congresses.

Cerebral anoxia--Congresses.

Genre:

Conference papers and proceedings.

Physical Description:

xii, 474 pages : illustrations ; 26 cm.

Contained In:

Place of Publication:

New York : Plenum Press, [1988]

Summary:

"The articles and short communications in this volume are based on papers presented to the Symposium on Cerebral Hypoxia and Stroke held in Budapest in August of 1987. Besides participants at the meeting, three scientists who were invited but could not attend have also contributed chapters to this volume. A synopsis of the general discussion at the conference and a review chapter conclude this volume. To the readers of this book it will not be news that stroke is a worldwide problem. Efforts to cope with this often devastating condition are worldwide also, as attested by the international membership of the conference. It has been said of oxygen deficiency that it not only stops the machine, it also wrecks the machinery. The paramount question in stroke research is this: why can't the brain be restarted after a hypoxic episode in much the same manner as a motor car can when its gas tank is refilled after it stalled because it ran out of fuel? Participants at the Symposium had been requested in advance of the meeting to especially consider a series of specific questions in relation to this general problem. Among these specific questions were: the mechanism of synaptic blockade in hypoxic brain tissue; the transition from reversible to irreversible arrest of function; the nature of postischemic (delayed) cell death; the possible basic differences in the consequences of hypoxia and ischemia; and actual and potential approaches to the prevention and treatment of cell damage in hypoxia and stroke."--Publisher's website.

Contents:

Adaptation In Diving Vertebrates:

Inborn resistance to hypoxia and the O2_dependence of metabolism / P. W. Hochachka

Brain vulnerability and survival during anoxia: protective strategies of hypoxia-resistant vertebrates / M. Rosenthal, Z.-C. Feng and T.J. Sick

General Pathology:

Early and late neuronal damage following cerebral ischemia / T. Kirino, A. Tamura, and K. Sano

Selective neuronal cell death after transient forebrain ischemia in th,e mongolian gerbiL / B.J. Crain and J.V. Nadler

Possible implications of ischemic damage to dentate hilar somatostatin neurons in the rat / F.F. Johansen, J. Zimmer and N.H. Diemer

Regulation of glutamate receptors in hippocampus after cerebral ischemia / E. Valente, F.F. Johansen and N.H. Diemer

Role of edema in the pathophysiology of ischemic injury / I. Klatzo

Acidosis-related brain damage immediate and delayed events / M.-L. Smith and B.K. Siesjo Pathology of ischaemic brain damage: implications for therapy / W. Meier-Ruge, D. Theodore and J. Abraham

Ischemic damage of rat hippocampus and basal ganglia: light microscopical and biochemical changes / R. Schmidt-Kastner, W. Paschen, J. Szymas, and K.-A. Hossmann

Pathophysiology:

Physiological aspects of brain ischaemia in the experimental primate and man / L. Symon

The dependency of cerebral ischemic damage on duration and severity of ischemia: studies of single cell activity and multimodality evoked responses / R. Graf, W.-D. Heiss, K.Kataoka, G. Rosner and A. Wakayama

Microcirculation and metabolism in reversible and irreversible cerebral ischemia / E. Dora, A.G.B. Kovach, J.H. Greenberg, K. Tanaka, N.H. Gonatas, and M. Reivich

Cerebral blood flow and its responsiveness to CO2 after traumatic and ischemic brain injuries / E. Moskalenko, G.B. Weinstein, V.E. Parfenov, M. Bodo and B.V. Gaidar

o The correlation between electrophysiological parameters (EEG, DC potential and tissue available O2) and regional metabolites (pH, ATP, glucose, NADH, K) after 45 min middle cerebral artery occlusion and 3 hours recirculation in cats / L. Csiba, D. Bereczki, W. Paschen and F. Linn

Cerebral hypoxia during repetitive seizures / N.R. Kreisman

Microcirculation, NAD/NADH fluorescence, extracellular potassium and glucose metabolism changes in focal cerebral ischemia / R. Urbanics, J.H. Greenberg and M. Reivich.

Neurons, glia and ions in hypoxia, hypercapnia and acidosis / A. Lehmenkuhler, H. Caspers, E.-J. Speckmann, D. Bingmann, H.G. Lipinski and U. Kersting

Effects of anoxia on nerve cell function / A. J. Hansen

Reversible synaptic blockade caused by hypoxia of moderate degree in hippocampal tissue slices / S.J. Schiff and G.G. Somjen

Anoxia reversibly inactivates hippocampal calcium currents / K. Kmjevic and J. Leblond Reversibility of neuronal function of hippocampal slice during deprivation of oxygen and/or glucose / Y. Okada

The effect of hypoxia on hippocampal neurones and its prevention by Ca2+-antagonists / H. Higashi, S. Sugita, S. Nishi, K. Shimoji

Anoxia in CAl pyramidal cells: ionic and metabolic factors contributing x to recovery of ion transport and synaptic transmission / T.J. Sick and E.L. Roberts Jr.

Long-term inhibition of synaptic transmission and macromolecular synthesis following anoxia in the rat hippocampal slice: interaction between Ca2+ and NMDA receptors / P. Lipton, K. Raley and D. Lobner

Early alterations in striatal and hippocampal impedance and extracellular amino acids by cardiac arrest in freely moving rats / J. Korf, H.C. Klein, K. Venema and F. Postema

Susceptibility to spreading depression and anoxia: regional differences and drug control / J. Bures and O. Buresova^^^urrents / K. Kmjevic and J. Leblond Blood flow and metabolism in cortical spreading depression / M. Lauritzen

Dynamics of volatile buffers in brain cells during spreading depression / R.P. Kraig and M. Chesler

The role of spreading depression-like hypoxic depolarization in irreversible neuron damage, and its prevention / M. Balestrino, P.O. Aitken, L.S. Jones and 0.0. Somjen

NMDA antagonists inhibit cortical spreading depression, but accelerate the onset of neuronal depolarization induced by asphyxia / R. Marranes, E. De Prins, R. Willems and A. Wauquier

Does Leao's spreading depression cause irreversible brain damage? / K. Kawasaki, O. Czeh and 0.0. Somjen

Electrophysiological and biochemical events in the isolated perfused rat brain under ischemia and reperfusion / D. Scheller, F. Tegtmeier, C. Weoer. U. Peters, I. Haker,E. Zacharias and M. Holler

Neurotransmitter modulation of neuronal damage following cerebral ischemia: Effects on protein ubiquitination K. Magnusson, I. Oustafsson, E. Westerberg and T. Wieloch

Detection of free radicals in cerebral tissue and their relation to cerebral hypoxia/ischemia / S. Imaizumi, T. Tominaga, H. Uenohara, H. Kinouchi, T. Yoshimoto, and J. Suzuki

Pharmacology:

The limits of reversibility from ischemic cerebral insult and our method of prolonging cerebral survival / J. Suzuki, K. Mizoi, H. Abiko, K. Ogasawara, M. Oba and T. Yoshimoto

Excitatory amino acid neurotransmission and protection against ischaemic brain damage / B. Meldrum, M. Evans and J. Swan

Excitatory amino acid and purinergic transmitter involvement in ischemia-induced selective neuronal death / O.A. Block and W.A. Pulsinelli

Protection of hippocampal neurons from "ischemic" insult in vitro by acidic amino acid antagonists / D.G. Roufa, T.H. Lanthom, R.K. Rader, S.R. Rapp and P.C. Contrerasn of neuronal damage following cerebral ischemia: Effects on protein ubiquitination Magnesium inhibits ischemia-induced calcium accumulation in hilar neurones: possible effect of NMDA-receptor / H. Benveniste and N.H. Diemer

Dopamine and the susceptibility of striatal neurons to ischemia / M.Y.-T. Globus, M.D. Ginsberg, R. Busto, W.D. Dietrich, E. Martinez, I. Valdez and P. Scheinberg

Effects of flunarizine on normal and injured rat cerebral cortex / K.H. Reid, R. Marranes and A. Wauquier

Improvement of postischemic cell damage and energy metabolism in the rat by flunarizine and emopamil / D. Sauer, G.W. Bielenberg, J. Nuglisch, T. Beck, H.D. Mennel, C. Rossberg and J. Krieglstein

Discrimination between vascular and direct effects on cerebral parenchyma of emopamil / G.W. Bielenberg and J. Krieglstein

Prophylaxis and therapy of hypoxic and ischemic brain: effects of monosialoganglioside GMI / C. Aldinio, M.S. Seren, G. Toffano and A. Leon

Adenosine neuromodulation of selectively vulnerable CAl neuronsn K.S. Lee and G.W. Kreutzberg

The nucleoside-transport inhibitor, mioflazine, increases recovery of hippocampal synaptic transmission and energy-rich metabolites after normothermic global ischemia / D. Ashton, H. van Belle, J. Wynants, R. Willems, A. Wauquier and P.A.J. Janssen

Glutamine protects neuronal function against hypoxia in vitro / A. Schurr, D.G. Changaris, C.A. West and B.M. Rigor

Cerebroprotective effect of histamine receptor blockers in hypoxia-induced experimental brain edema / E. Dux, P. Temesvari, F. Joo and P. Szerdahelyi

Drug effects on cerebral extracellular ionic derangement during ischemic hypoxia / D. Heuser, H. Guggenbergerand B. Kotter

Discussion And Conclusions:

General discussion: a synopsis

Basic mechanisms in cerebral hypoxia and stroke: background, review and conclusions / G.G. Somjen.

Notes:

"Papers presented to the Symposium on Cerebral Hypoxia and Stroke held in Budapest in August 1987"--Foreword.

A satellite meeting of the Second World Congress of Neuroscience (IBRO).

Includes bibliographical references and indexes.

Other Format:

Online version: Mechanisms of cerebral hypoxia and stroke.

ISBN:

0306430150

9780306430152

OCLC:

18350360