Basic mechanisms of the epilepsies : molecular and cellular approaches / editors, Antonio V. Delgado-Escueta [and others].

Format:

Book

Conference/Event

Contributor:

Delgado-Escueta, Antonio V.

National Institute of Neurological and Communicative Disorders and Stroke. Epilepsy Advisory Committee. Subcommittee on Basic Research.

Conference Name:

International Symposium on Basic Mechanisms of the Epilepsies (1983 : San Diego, Calif.)

Series:

Advances in neurology ; v. 44.

Advances in neurology ; v. 44

Language:

English

Subjects (All):

Epilepsy--Congresses.

Epilepsy.

Pathology, Molecular--Congresses.

Pathology, Molecular.

Pathology, Cellular--Congresses.

Pathology, Cellular.

Medical Subjects:

Epilepsy.

Genre:

Kongress -- San Diego (Calif.) -- 1982.

Conference papers and proceedings.

Physical Description:

xxiv, 1096 pages : illustrations ; 27 cm.

Place of Publication:

New York : Raven Press, 1986.

Language Note:

Based on workshops held at the Kroc Foundation headquarters in Calif. in Dec. 1982 and during the International Symposium on Basic Mechanisms of the Epilepsies, held in San Diego, Dec. 1983; both sponsored by the Subcommittee on Basic Research of the Epilepsy Advisory Committee, National Institute of Neurological and Communicative Disorders and Stroke.

Contents:

New wave of research in the epilepsies

Genetic heterogeneity in the epilepsies

Looking for epilepsy genes: clinical and molecular genetic studies

Mutational analysis of inherited epilepsies

Inherited convulsive disorders in mice

Voltage-dependent currents of vertebrate neurons and their role in membrane excitability

Toward a mechanism of gating of chemically activated channels

Conducting sites in excitable membranes

Modulators acting on sodium and calcium channels: patch-clamp analysis

Role of persistent inward and outward membrane currents in epileptiform bursting in mammalian neurons

Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates

Control theory applied to neural networks illuminates synaptic basis of interictal epileptiform activity

Mechanisms of interictal epileptogenesis

Kindling model of epilepsy

Failure of GABAergic inhibition: a key to local and global seizures

Role of the substantia nigra in GABA-mediated anticonvulsant actions

Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy.

Gaba receptors, lipids, and gangliosides in cobalt epileptic focus

Roles of biogenic amines and cyclic nucleotides in seizure mechanisms

Long-term potentiation and kindling: similar biochemical mechanisms?

Synaptic mechanisms in the kindled epileptic focus: a speculative synthesis

Molecular approach to the calcium signal in brain: relationship to synaptic modulation and seizure discharge

Cerebral methylations in epileptogenesis

Role of noradrenergic ascending system in extinction of epileptic phenomena

Neuropeptides: anticonvulsant and convulsant mechanisms in epileptic model systems and in humans

Opioid peptides and epileptogenesis in the limbic system: cellular mechanisms

Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis

Temporal and spatial distribution of intracellular potentials during generation and spread of epileptogenic discharge

Cellular basis of neuronal synchrony in epilepsy

Role of electrical interactions in synchronization of epileptiform bursts

Ionic changes and alterations in the size of the extracellular space during epileptic activity

Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue

Interstitial ion concentrations and paroxysmal discharges in hippocampal formation and spinal cord.

Na+, K+-ATPase: structure, function, and interactions with drugs

Role of glial cation and anion transport mechanisms in etiology and arrest of seizures

Anticonvulsant drugs: mechanisms of action

Contemporary methods in neurocytology and their application to the study of epilepsy

Freeze-fracture studies of plasma membranes of astrocytes in freezing lesions

Structural substrates of epilepsy

Epilepsy and the blood-brain barrier

Epileptic brain damage: pathophysiology and neurochemical pathology

Cell damage in epilepsy and the role of calcium in cytotoxicity

Excitotoxic mechanisms of epileptic brain damage

Accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy

Brain protein metabolism in epilepsy

identification of seizure-mediating brain structures with the deoxyglucose method: studies of human epilepsy with positron emission tomography, and animal seizure models with contact autoradiography

Regional cerebral blood flow and metabolic rates in human focal epilepsy and status epilepticus

Neuronal, dendritic, and vascular profiles of human temporal lobe epilepsy correlated with cellular physiology in vivo

Neuronal firing patterns from epiletogenic foci on monkey and human

Hippocampal slices in experimental and human epilepsy

Amino acid and catecholamine markers of metabolic abnormalities in human focal epilepsy

Alterations of GABA-mediated synaptic transmission in human epilepsy

Neuron-glia relationships in human and experimental epilepsy: a biochemical point of view.

Notes:

Based on workshops held at the Kroc Foundation headquarters in Calif. in Dec. 1982 and during the International Symposium on Basic Mechanisms of the Epilepsies, held in San Diego, Dec. 1983; both sponsored by the Subcommittee on Basic Research of the Epilepsy Advisory Committee, National Institute of Neurological and Communicative Disorders and Stroke.

Includes bibliographical references and index.

Other Format:

Online version: Basic mechanisms of the epilepsies.

ISBN:

0881671525

9780881671520

OCLC:

12838100