Neuropathology of aging and Alzheimer's disease / Rudy J. Castellani.

Format:

Book

Author/Creator:

Castellani, Rudy J., author.

Language:

English

Subjects (All):

Alzheimer's disease.

Alzheimer's disease--Age factors.

Physical Description:

1 online resource (351 pages)

Edition:

1st ed.

Place of Publication:

Amsterdam, Netherlands : Elsevier, [2025]

Summary:

Neuropathology of Aging and Alzheimer's Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer's Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.- Detailed discussion and analysis of early Alzheimer's disease investigators and their findings- Detailed discussion and analysis of the often-overlooked literature from the 1920's to the 1960's- Detailed discussion and analysis of aging-related phenomena currently under study- Detailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathy- Detailed discussion and analysis of the pathology of autosomal dominant Alzheimer's disease and Alzheimer's disease associated with Down syndrome- Practical issues with diagnosing and reporting Alzheimer's disease and aging-related changes

Contents:

Front Cover

Neuropathology of Aging and Alzheimer's Disease

Copyright Page

Contents

Preface

I. Alzheimer and his contemporaries

1 Alzheimer's disease: a fortuitous beginning

References

2 Alzheimer's first case

3 Alzheimer's second case and the naming of Alzheimer's disease

4 Some early observations of Alzheimer's contemporaries

5 Early studies on senile dementia and aging

Oskar Fischer

Teofil Simchowicz

Solomon Carter Fuller

Albert M. Barrett

6 The human element

II. The dark ages

7 The 1920s and 1930s

Introduction to the dark ages

Uyematsu, 1923

Oseki, 1924

Von Braunmuhl

Gruenthal, 1926

Malamud and Lowenberg, 1929

Henderson and Machlachlan, 1930

Critchley, 1929-1931

Ferraro, 1931, 1941

Gellerstadt, 1933

Bouman, 1934

Rothschild, Lowenberg, and Kasanin, 1931-1937

Rothschild and Kasanin, 1936

Rothschild and Trainor, 1937

Hannah, 1936

Jervis, 1937

8 The 1940s to the 1960s

McMenemey, 1940

English, 1940, 1942

Soniat, 1941

R.D. Newton, 1947

Goodman, 1953

Neumann and Cohn, 1953

Margolis, 1959

Corsellis 1961

Hirano and Zimmerman, 1962

Kidd, 1963-1964, Terry 1963

Blessed, Tomlinson, Roth, 1968

III. Beyond plaques and tangles: lewy bodies, vascular disease, and the rise of the acronyms

9 Lewy bodies

Lewy bodies and Parkinson's disease

Lewy body dementia

10 The role of vascular disease in Alzheimer's disease neuropathology

Atherosclerosis

Cerebral small-vessel disease

1 Vascular disease and cognition

Cerebral amyloid angiopathy

Summary

11 The rise of the acronym

12 Aging-related neuronal tau

Introduction

The Concept of "Tauopathy".

Primary age-related tauopathy

13 Aging and disease-related astrocytic tau

14 TDP-43 in aging and Alzheimer's disease

15 Argyrophilic grain disease

IV. Alzheimer's disease, dementia pugilistica, and the influence of neuropathology

16 Introduction to the traumatic brain injury-neurodegenerative disease dichotomy

17 Punch drunk syndrome: the first 30 years

18 Clinicopathological analysis from the 1950s and 1960s

Brandenburg and Hallervorden

Grahmann and Ule

Neubuerger, et al.

Courville

Mawdsley and Ferguson

Constantinidis and Tissot

Payne

Roberts' epidemiological study

19 1970 to 2000: transitioning to an immunohistochemistry-only diagnosis

The Corsellis et al. study

Studies from the 1990s and early 2000s

Roberts-domestic abuse

Hof and colleagues-the issue of superficial laminae tau and boxing

Subtle changes in people with a history of head impacts

Alcoholic achondroplastic dwarf

A case of Alzheimer's disease decades after a boxing career

A questionable diagnosis of "dementia pugilistica" in the New England Journal of Medicine

Additional anecdotal and problematic reports of boxers in the 2000s

20 The modern chronic traumatic encephalopathy era

The first case in professional football

Additional cases, 2006-11

Attention shifts to another research group

2009 Article

2013 Article

2016 Consensus article

2021 Consensus article

Traumatic encephalopathy syndrome

21 Postmortem of punch drunk boxers and chronic traumatic encephalopathy

V. Familial alzheimer's disease, down syndrome, and the amyloid cascade hypothesis.

22 Familial Alzheimer's disease and Down syndrome

Familial Alzheimer's disease

Familial amyloidosis associated with βAPP mutation

Familial amyloidosis associated with PSEN1 mutation

Familial amyloidosis associated with PSEN2 mutation

Comparisons across mutations

Down syndrome

Summary of familial Alzheimer's disease and Down syndrome

23 The amyloid cascade hypothesis

The question

Genetic studies of the late 20th century

Soluble mediators

Rhetoric

Evidence base from amyloid-β-targeted experimental therapy

VI. Practical considerations in the diagnosis of alzheimer's disease and aging

24 Application of consensus criteria

Tissue sampling and staining for Alzheimer's disease

Histochemistry

Immunohistochemistry

Consensus panels on Alzheimer's disease and aging

Khachaturian criteria

Consortium to Establish a Registry for Alzheimer's Disease

Braak staging

2012 ABC guidelines

25 The diagnostic process

Index

Back Cover.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

ISBN:

9780323996525

0-323-99652-3

OCLC:

1520883604