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Microbiota-gut-brain axis and CNS disorders : recent progress and perspectives / edited by Neeraj Mishra and Anoop Kumar.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Mental illness.
- Physical Description:
- 1 online resource (516 pages)
- Edition:
- First edition.
- Place of Publication:
- London, England : Academic Press, [2025]
- Summary:
- Microbiota-Gut-Brain Axis and CNS Disorders: Recent Progress and Perspectives on Human Disease summarizes the main findings on gut-brain axis in different types of CNS disorders, providing a complete overview of the field.
- Contents:
- Front Cover
- Microbiota-Gut-Brain Axis and CNS Disorders
- Microbiota-Gut-Brain Axis and CNS Disorders Recent Progress and Perspectives
- Copyright
- Contents
- Contributors
- 1 - Overview of microbiota gut-brain-axis
- Introduction
- Microbiota: Friends with benefits
- Gut-brain axis
- Microbiota-gut-brain axis
- Evolution, microbiota, and the holobiont
- Bidirectional communication of the gut-brain axis
- Gut microbiota
- Gut-brain axis links
- From gut microbiota to brain axis
- From brain to gut microbiota
- Microbiota-gut-brain axis's role in neurotransmitter modulation
- Comprehend the functional significance of microbes in the gut-brain axis
- Physiological and pathological role of microbiota in the gut-brain axis
- Physiological functions
- Pathophysiological functions
- Gut microbiome in neurological disorders
- Studying the microbiota-gut-brain axis
- Perspectives
- Concluding remarks
- References
- 2 - Role of microbiota-gut-brain axis in Alzheimer's disease and possible interventions
- Introduction to gut microbiota
- Role of gut microbiota in the development of the brain
- Influence of microbiota-gut-brain axis on neurodegenerative disease
- Introduction to Alzheimer's disease
- Pathogenesis of Alzheimer's disease
- Microbiota-gut-brain axis dysbiosis and Alzheimer's disease
- Role of microbiota in neurotransmitter synthesis
- Role of short chain fatty acids in neurodegeneration
- Bacterial amyloids
- Lipopolysaccharides and fragments of bacterial cells
- Vagus nerve conduction
- Blood-brain barrier permeability
- Neuroinflammation and neurodegeneration
- Possible interventions targeting gut microbiome in Alzheimer's disease
- Dietary interventions
- Probiotics, prebiotics and synbiotics
- Fecal microbiota transplantation
- Other diets
- Mediterranean diet.
- Vegetarian/vegan diet
- Ketogenic diet
- Conclusion
- 3 - Role of microbiota gut-brain axis in Parkinson's disease
- Gastrointestinal dysfunction in Parkinson's disease
- Pathophysiology of gastrointestinal dysfunction in Parkinson's disease
- Gastrointestinal tract and associated brain areas
- Lewy bodies
- Gastrointestinal manifestations in autonomic disorders
- Constipation
- Swallowing disorders
- Drooling
- Dysphagia
- Helicobacter pylori infection
- Malnutrition
- Small intestinal dysfunction
- Colonic and anorectal dysfunction
- Alpha-synuclein pathology in Parkinson's disease
- Mechanisms of transmission (α-synuclein cell-to-cell spreading model)
- Aggregation of α-syn
- Uptake
- Processing
- Release
- Therapeutic implications of transmission
- Glymphatic clearance
- α-synuclein immunotherapy
- Noncell autonomous targets
- α-synuclein receptor inhibition
- Targeting the gut
- Microbiota targeted interventions for Parkinson's disease
- Prebiotics
- Probiotics
- Synbiotics
- Diet
- Future perspectives and conclusive remarks
- Declaration
- Abbreviations
- 4 - Role of microbiota-gut-brain axis in Huntington's disease and possible interventions
- Microbiota-gut-brain axis and Huntington's disease
- Possible interventions targeting the microbiota-gut-brain axis in Huntington's disease
- Drugs targeting gut microbiota and central nervous system function
- Metformin
- Clinical implications and future directions
- References.
- 5 - Crosstalk between gut-brain axis and brain components along with associated neurological disorders
- Central nervous system component involved in gut-brain axis function
- Immune cells
- Microglia and astrocytes
- Neurogenesis
- Blood-brain barrier
- Vagus nerve
- Neurotransmitters involved in gut-brain interaction
- Serotonin
- Catecholamine
- Neuropeptides involved in gut-brain interaction
- Association of gut-brain axis with different neurological disorders
- Gut-brain axis in depression and anxiety
- Gut-brain axis in Alzheimer's disease
- Gut-brain axis in Parkinson's disease
- Gut-brain axis in amyotrophic lateral sclerosis
- Gut-brain axis in autism spectrum disorder
- Gut brain axis in schizophrenia
- Gut-brain axis in multiple sclerosis
- Gut-brain axis in stroke
- Gut-brain axis in epilepsy
- 6 - Role of microbiome-gut-brain axis in autism spectrum disorder
- Epidemiology and comorbidities and pathophysiology
- Pharmacological treatment options
- Role of gut-brain axis in autism spectrum disorder
- Therapeutic involvement of gut microbiota in autism spectrum disorder
- 7 - Role of microbiota-gut-brain axis in autoimmunity and multiple sclerosis
- Gut-microbiota and its role in immune system regulation
- Myeloid cell regulation
- Neutrophils
- Intestinal eosinophils
- Intestinal macrophages
- Microglia
- Astrocytes
- T cell regulation
- Th17 cells
- Treg cells
- Invariant natural killer T cells
- B cell regulation
- IgA-production
- IgG-production
- IgE-production
- Other lymphoid immune cells regulation
- Innate lymphoid cells
- Gut-associated lymphoid tissues
- Dysbiosis and leaky gut syndrome facilitate autoimmune diseases.
- Connection between the gut-microbiome and related immunity in multiple sclerosis
- Strategies for commensal microbiome upregulation to treat autoimmune disorders including multiple sclerosis
- Summary and conclusions
- 8 - Negative impact of stress on gut-brain axis
- Background
- Brain gut microbial axis
- How stress affects microbial diversity
- Possible mechanism through which stress can affect the gut-brain-microbial axis
- Activation of hypothalamic-pituitary-adrenal axis
- Role of corticotrophin releasing hormone
- Role of zonulin
- Presence of food-borne pathogen
- Production of proinflammatory cytokines
- Evidences of how stress can alter gut microbiota composition
- Role of probiotics in the reduction of stress
- Disorders of brain-gut microbiota axis
- Irritable bowel syndrome
- Depression
- Schizophrenia
- Autism spectrum disorder
- Parkinson's disease
- Alzheimer's disease
- Multiple sclerosis
- 9 - Role of microbiota-gut-brain axis in epilepsy and possible interventions
- Role of gut microbiota in epilepsy
- Modulation of gut microbiota for managing epilepsy
- Antiepileptics
- Antibiotics
- Prebiotics, probiotics, and synbiotics
- Modified diets (ketogenic diet and atkins diet)
- Fecal matter transplantation
- Cannabidiol
- 10 - Role of microbiota-gut-brain axis in migraine and possible interventions
- Nerve pathway
- Neuroendocrine pathway
- Immune pathway
- Several types of epithelial barriers
- Epidemiology
- Pathophysiology
- Role of different types of neurotransmitters
- Acetylcholine
- Dopamine
- Norepinephrine
- Gamma-aminobutyric acid
- Glutamate
- Microbiota-gut-brain axis in migraine and neurological diseases
- Clinical trial studies.
- Conclusion and future prospectives
- Conflict of interest
- 11 - Role of microbiota gut brain axis in stroke and its possible intervention
- Relevance of gut brain axis in stroke
- The influence of gut dysbiosis on stroke risk factors
- Aging
- Metabolic diseases
- Arterial hypertension and vascular dysfunction
- Mechanisms of gut microbiota brain relationships
- Neural pathways
- Immune pathways
- Neuroactive pathway
- Hypothalamic pituitary adrenal axis pathways
- Microbial signaling molecules
- Short-chain fatty acids
- Tryptophan metabolites
- Bile acids
- Trimethylamine N-oxide
- Modulation of the gut microbiota as a stroke treatment strategy
- Use of probiotics and prebiotics in stroke
- Fecal microbiome transplantation
- Antibiotics use in stroke victims
- Conclusion and outlook
- 12 - Role of microbiota-gut-brain axis in brain infections and possible interventions
- Microbiota-mediated communicative mechanisms in brain infections
- Trimethylamine/trimethylamine N-oxide
- Short-chain fatty acid
- Tryptophan
- Neurotransmitter release
- Neuropeptide calcitonin gene-related peptide
- Pituitary adenylate cyclase-activating polypeptide
- Ghrelin
- Peptide YY
- Leptin
- Glucagon-like peptide 1
- Gut-brain axis mediated communicative mechanisms in brain infections
- Endocrine pathways
- Metabolites pathways
- Microbiota that influences gut-brain axis mechanisms in brain infections
- Gut-brain axis mechanisms that influence microbiota-based mechanisms in brain infection
- Possible interventions
- Probiotic/postbiotics
- Conclusion and future perspectives
- 13 - Role of microbiome gut-brain axis in brain disorders.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9780443216817
- 0443216819
- OCLC:
- 1492990571
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