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Chimeric autoantibody receptor t cells for targeted depletion of myeloperoxidase-specific anti-neutrophil cytoplasmic antibody-producing b cells Heather M Sosnoski
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Sosnoski, Heather M., author.
- Language:
- English
- Subjects (All):
- Immunology.
- Cellular biology.
- Therapy.
- 0982.
- 0379.
- 0212.
- Local Subjects:
- Immunology.
- Cellular biology.
- Therapy.
- 0982.
- 0379.
- 0212.
- Genre:
- Academic theses
- Physical Description:
- 1 online resource (113 pages)
- Contained In:
- Dissertations Abstracts International 87-12A
- Place of Publication:
- Ann Arbor : ProQuest Dissertations and Theses, 2026
- Language Note:
- English
- Summary:
- Anti-neutrophil cytoplasmic antibody (ANCA) vasculitides are autoimmune disorders driven byautoantibodies against neutrophil granule proteins, myeloperoxidase (MPO) and proteinase 3(PR3), that cause necrotizing small-vessel inflammation with prominent lung and kidneyinvolvement, resulting in pulmonary hemorrhage and glomerulonephritis. Current remission inductionregimens rely on broad immunosuppression and global B cell depletion, which areeffective but associated with substantial infection risk and relapse that often necessitatesrepetitive, long-term treatment. Here, we develop MPO chimeric autoantibody receptor (CAAR) Tcells as a target-specific therapy to eliminate MPO-autoreactive B cells. MPO CAAR T cellsselectively eliminate anti-MPO BCR-expressing B cell lines in vitro and in vivo. In primary murineautoreactive B cell cultures, MPO CAAR T cells suppressed anti-MPO IgG production withoutinducing global B cell depletion. Together, these findings support MPO CAAR T cells as aprecision approach to eliminate pathogenic B cells in ANCA vasculitis, potentially eliminating theneed for generalized humoral immunosuppression
- Notes:
- Source: Dissertations Abstracts International, Volume: 87-12, Section: A.
- Advisors: Posey, Avery D., Jr. Committee members: Song, Wenchao; Bhoj, Vijay; Rhee, Rennie L.; Allman, David
- Ph.D. University of Pennsylvania 2026
- Vendor supplied data
- Local Notes:
- School code: 0175
- ISBN:
- 9798247983125
- Access Restriction:
- Restricted for use by site license
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