Innate immune control of early-life neurotropic viruses Carl Bannerman

Format:

Book

Thesis/Dissertation

Author/Creator:

Bannerman, Carl, author.

Contributor:

University of Pennsylvania. Cell and Molecular Biology., degree granting institution.

Language:

English

Subjects (All):

Virology.

Immunology.

Neurosciences.

0720.

0982.

0317.

Local Subjects:

Virology.

Immunology.

Neurosciences.

0720.

0982.

0317.

Genre:

Academic theses

Physical Description:

1 online resource (132 pages)

Contained In:

Dissertations Abstracts International 87-12B

Place of Publication:

Ann Arbor : ProQuest Dissertations and Theses, 2026

Language Note:

English

Summary:

The central nervous system must delicately balance immune responses to eliminate viruses, while also preserving the predominantly post-mitotic, non-renewable mature neuron population. Neurotropic viruses target neurons during infection, however whether neurons mount an effective type I interferon (IFN) innate immune response remains debated. As many emerging and re-emerging viruses have potential to evolve and become increasingly pathogenic, understanding innate immune response to virus remains essential. This thesis shows that the re-emerging Oropouche virus (OROV) induces a microcephaly-like phenotype in human forebrain organoids, characterized by decreased neuronal rosettes, reduced organoid size and enhanced neural progenitor cell death. Work here further demonstrates that OROV induces rapid morbidity and mortality in neonate mice, with capacity to induce fetal abnormalities during congenital infection. Additionally, with a focus on neuronal innate immune responses to early-life neurotropic virus infection, this thesis shows that neurons have varying expression patterns of and responses to different type I IFN subtypes. Specifically, exogenous IFNε does not induce an effective antiviral state in neurons, in contrast to IFNβ, partially due to a lack of ISG translation. Uncoupling ISG transcription from translation suggests a potential novel role for a noncanonical type I IFN subtype. Collectively, my thesis underscores mechanisms by which emerging and re-emerging viruses may cause adverse neurodevelopmental outcomes. The work described here also furthers our understanding of type I IFN regulation in neurons by uncovering post-transcriptional regulation of interferon stimulated genes, unique to type I IFN subtypes

Notes:

Source: Dissertations Abstracts International, Volume: 87-12, Section: B.

Advisors: Jurado, Kellie A. Committee members: Jordan-Sciutto, Kelly L.; Weiss, Susan R.; Ming, Guo-li; Miner, Jonathan J.

Ph.D. University of Pennsylvania 2026

Vendor supplied data

Local Notes:

School code: 0175

ISBN:

9798247973478

Access Restriction:

Restricted for use by site license