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Hippocampal circuit alterations and microglial contributions to learning and memory dysfunctions following mild traumatic brain injury Samuelle A. S Delcy
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Delcy, Samuelle A. S., author.
- Language:
- English
- Subjects (All):
- Neurosciences.
- Immunology.
- Physiology.
- Electrical engineering.
- 0317.
- 0982.
- 0719.
- 0544.
- Local Subjects:
- Neurosciences.
- Immunology.
- Physiology.
- Electrical engineering.
- 0317.
- 0982.
- 0719.
- 0544.
- Genre:
- Academic theses
- Physical Description:
- 1 online resource (196 pages)
- Contained In:
- Dissertations Abstracts International 87-12B
- Place of Publication:
- Ann Arbor : ProQuest Dissertations and Theses, 2026
- Language Note:
- English
- Summary:
- Traumatic brain injury (TBI) affects over 69 million people annually worldwide, with mild TBI (mTBI) accounting for 70-90% of cases. TBI consists of primary injury caused by mechanical impact and secondary injury driven by biochemical and physiological processes, including neuroinflammation. Neuroinflammatory responses, mediated in part by activated microglia, the primary immune cells of the brain, play a critical role in determining post-injury recovery and long-term memory dysfunctions. This work examines how microglia-mediated inflammation influences hippocampal circuit physiology and memory outcomes following mTBI, while highlighting sex differences. Using a mouse model of mTBI, changes in area CA1 and dentate gyrus network activity were examined during the acute (7-10 days) and the chronic (30 days) period. Acute microglia depletion restored hippocampal neuronal activity and improved memory performance in male mice. In female mice, memory and electrophysiological deficits were present but less pronounced, suggesting the presence of protective mechanisms that may buffer against inflammation-driven circuit dysfunction following injury. Together, these findings identify microglia-mediated inflammation as a key driver of hippocampal dysfunction after mTBI and highlight the importance of incorporating sex as a biological variable when evaluating injury mechanisms. Importantly, this work extends beyond the laboratory and includes a review of concussion in school-age children, a population disproportionately affected yet underrepresented in research and clinical protocols, with particular attention to girls and racially minoritized youth
- Notes:
- Source: Dissertations Abstracts International, Volume: 87-12, Section: B.
- Advisors: Cohen, Akiva S. Committee members: Cullen, Kacy D.; Bennett, Frederick Chris; Ma, Minghong; Jordan-Scuitto, Kelly L.
- Ph.D. University of Pennsylvania 2026
- Vendor supplied data
- Local Notes:
- School code: 0175
- ISBN:
- 9798247979043
- Access Restriction:
- Restricted for use by site license
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