Metabolic Syndrome.

Format:

Book

Author/Creator:

Uzun, Hafize.

Contributor:

Dumur, Seyma.

Language:

English

Physical Description:

1 online resource (453 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2025.

Summary:

The book focuses on a new interdisciplinary understanding of the metabolic syndrome (MetS) for better health maintenance. It provides an updated understanding of the underlying principles, possible targets, implementation approaches and the effectiveness of various avoidance strategies in MetS. The chapters cover a wide range of topics, including major advances in general aspects of metabolic syndrome, functional changes, new diagnostic methods, genotype-phenotype associations, the effect of exercise and multitarget pharmacotherapeutic strategies for MetS and perspectives on personalized medicine. It also discusses epigenetic mechanisms underlying MetS-related processes and epigenetic strategies to prevent related diseases. The book also presents summarized information about the associated factors and mechanisms linking cancer and MetS and to identify potential targets for the treatment of these patients. A better understanding of the various linkages will provide greater insight into the management of cancer patients by preventing MetS and related alterations. Key Features - Comprehensive information focused on the biological factors and physiological changes associated with metabolic syndrome - Updates on metabolic syndrome diagnosis and management - Summarized information on clinical implications for cancer therapy - Thoroughly referenced chapters with summaries and discussions for quick understanding The book is an informative resource for interdisciplinary scientists and researchers in life sciences and medicine. Furthermore, it, including the insulin-like growth factor (IGF-1) pathway, estrogen signaling, visceral adiposity, hyperinsulinemia, hyperglycemia, aromatase activity, adipokinase production, angiogenesis, oxidative stress, DNA damage and pro-inflammatory cytokines, and their clinical implications in cancer therapy. Readership

General readers, microbiology and biotechnology enthusiasts, science students and industrial trainees.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

General Aspects of Metabolic Syndrome: An Update on Diagnostic Criteria, Pathophysiology, and Management

Abdulhalim Senyigit1,*

INTRODUCTION

Prevalence of Metabolic Syndrome

Significance of Metabolic Syndrome

Pathogenesis of Metabolic Syndrome

Diagnostic Criteria of Metabolic Syndrome

According to the WHO's 1998 Diagnostic Criteria for Metabolic Syndrome [28]

According to the Diagnostic Criteria of NCEP-ATP III [8]

According to the IDF's 2005 Diagnostic Criteria for MetS [29]

Risk Factors of Metabolic Syndrome

COMPONENTS OF METABOLIC SYNDROME

Metabolic Syndrome and Obesity

Metabolic Syndrome and Insulin Resistance

Metabolic Syndrome and Prediabetes

Metabolic Syndrome and Diabetes Mellitus

Metabolic Syndrome and Hypertension

Metabolic Syndrome and Dyslipidemia (Hyperlipidemia)

Metabolic Syndrome and Endothelial Dysfunction

Vascular Inflammation and Prothrombotic Status in Metabolic Syndrome

Metabolic Syndrome and Non-alcoholic Fatty Liver Disease

TREATMENT

CONCLUSION

REFERENCES

Functional Changes in Metabolic Syndrome

Esra Bihter Gürler1, Hülya Çevik ARAS2 and Nagihan Bostanci3,*

Role of Visceral Fat and Adipokines (Adipocytes) in Metabolic Syndrome

Role of Lectin-Like Oxidized Low-Density Lipoprotein (LOX) Activation

Angiotensin II and Lox (lectin-like Oxidized low-density Lipoprotein) Activation

The Role of Insulin Resistance and Adipose Tissue

Role of Oxidative Stress

Role of the Oral-Gut-Liver Axis in Metabolic Dysfunction

New Approach to the Diagnosis of Metabolic Syndrome in Children

Omer Okuyan1,*

THE DEFINITION OF THE METABOLIC SYNDROME.

EPIDEMIOLOGY OF THE METABOLIC SYNDROME

PATHOGENESIS OF THE METABOLIC SYNDROME

Risk Factors

CLINICAL FEATURES OF THE METABOLIC SYNDROME

Obesity

Insulin resistance and hyperinsulinaemia

Insulin measurement methods

HOMA-IR is calculated according to the following formulas:

The Fasting Insulin Sensitivity Index is Calculated According to the Formula [81] (Table 5):

Hypertension (HT)

Dyslipidaemia

SCREENING OF THE METABOLIC SYNDROME

PREVENTION AND TREATMENT OF METABOLIC SYNDROME

CONCLUDING REMARKS

Association of Metabolic Syndrome with Gastrointestinal Disorders

Berrin Papila1,*

Synonyms of MetS

Epidemiology of Metabolic Syndrome

Diagnostic Criteria for Metabolic Syndrome

National Cholesterol Education Programme 3rd Adult Treatment Panel (NCEP ATP III) Description

Components of Metabolic Syndrome

Gastrointestinal System

Zonulin

Microbiota

Gut Microbiota

Gut Microbiota and Metabolic Syndrome

Related Anatomy of Gastrointestinal, Endocrine, Urinary, Nervous System and Morphometric Evaluation in Metabolic Syndrome

Hurriyet Cetinok1,*

Pathoanatomical Approach of the Gastrointestinal System in Metabolic Syndrome

Clinical Anatomy of Endocrine &amp

Urinary System in Metabolic Syndrome

Clinical Anatomy of Nervous System in Metabolic Syndrome

New Insights of Morphometric Evaluation in Metabolic Syndrome

Novel Metabolic Panel in Metabolic Syndrome

Dahlia Ibrahim Badran1,*

MetS biomarkers

Adipokines

Oxidative Stress Biomarkers

Inflammatory Markers

How Would Metabolic Syndrome Disturb the Normal Endothelial Function?

Eman Mamdouh Kolieb1 and Dina A Ali2,*.

INTRODUCTION

Vascular Endothelium and its Physiological Function

Disturbed Endothelial Function

Insulin Resistance in METS and Endothelial Dysfunction

Hyperglycemia in MetS and Endothelial Dysfunction

Molecular Mechanisms Underlying Metabolic Syndrome

Marwa Mohamed Hosny1,*, Nora Hosny2 and Ahmed Saber Shams2

INTRODUCTION THE CONVERGENCE OF GENETIC, ENVIRONMENTAL FACTORS AND MOLECULAR PATHWAYS IN METABOLIC SYNDROME

Insulin Resistance

Insulin Resistance and Increased Blood Glucose Level

Insulin Resistance and Disrupted Lipid Metabolism

Insulin Resistance and Pro-inflammatory State

Adipose Tissue Dysfunction and Stresses

Adipocyte Hypertrophy

Hypoxia and its Role in Adipose Tissue Dysfunction

Adipose Tissue Stresses and Stress-Responsive Signaling Pathways

Immune Cell Infiltration and Inflammation in Adipose Tissue

ER Stress and Unfolded Protein Response (UPR) in Obesity

Autophagy and its Role in Obesity

Adipokines as Mediators of Adipose Tissue Dysfunction in Obesity

Genetic Factors

Heritability of the Metabolic Syndrome

Single-gene Human Models

Genome-wide Linkage Scanning

Genetic Association Studies

Epigenetics and Regulatory RNAs in the Pathogenesis of Metabolic Syndrome

Mitochondrial Dysfunction and Oxidative Stress

Brown Adipose Tissue (BAT)

Dyslipidemia

SUMMARY

Excessive Caloric Intake and Reduced Energy Expenditure

Hypertriglyceridemia

Low HDL Cholesterol

Hyperglycemia

Pancreatic Beta Cell Dysfunction

Chronic Systemic Inflammation and Oxidative Stress

Adipocyte Stress and Local Tissue Hypoxia

Macrophage Infiltration

Propagation of Inflammation

Effects of Altered Adipokine Milieu and Inflammation

REFERENCES.

Modulation of Genotype-Phenotype Associations in Metabolic Syndrome

Sinem Firtina1,* and Asli Kutlu2

Association between Genetic Factors and Metabolic Syndrome

Modulation of Metabolic Syndrome and Risk Management

The Role of Omics-data in Personalized Medicine Approach in MetS

Personalized Medicine Approach in MetS

The Interplay between Metabolic Syndrome and Behavior

Shimaa Mohammad Yousof1,* and Asmaa Seddek2

The Relationship between MetS and Neuropsychiatric Diseases

Suggested Mechanisms Beyond the Relationship between MetS and Mental Illnesses

Metabolic Syndrome and Stress

Metabolic Syndrome and Cognitive Function

Metabolic Syndrome and Biological Rhythms

Microbiota, Metabolic Syndrome, and Behavior

Behavioral Therapy for Metabolic Syndrome &amp

Its Comorbid Conditions

Neutrogenomic Strategies in Metabolic Syndrome

Noura Ramadan Abdel-hamid1,*

GENES RELATED TO METS

PATHWAYS INVOLVED IN METS

GENETIC REGULATION IN METS

NEUTROGENOMIC STRATEGIES IN METS

Transcriptomics Tools

Proteomics Tools

Metabolomic Tools

Epigenetic Tools

Lipids

Carbohydrates

Proteins

Multitarget Pharmacotherapeutic Strategies for Metabolic Syndrome and Related Disorders: Perspectives on Personalized Medicine Using a Pharmacology Network Approach

Samah M. Elaidy1,*, Fatma S. Samman1 and Samar Imbaby1

METABOLIC SYNDROME AND RELATED DISORDERS

POLYPHARMACY APPROACH FOR METS AND RELATED DISORDERS

ROLES OF PRECISION MEDICINE IN METS AND RELATED DISORDERS

PHARMACOLOGY NETWORK APPROACH FOR POTENTIAL TARGET EXPLORATION IN METS AND RELATED DISORDERS.

Common Workflow for Pharmacology Network Approach and Bioinformatics Analytical Tools Used in MetS and Related Disorders

POTENTIAL MOLECULAR MULTITARGETS FOR PHARMACOTHERAPEUTICS IN METS AND RELATED DISORDERS

Type 2 Diabetes Mellitus

Obesity &amp

T2DM

Ischemia And Diabetes

Diabetes and Nephropathy

Role of Exercise in Metabolic Syndrome

Seyma Dumur1,*

METABOLIC SYNDROME AND EXERCISE

Physical Exercise

Endocrinological and Metabolic Effects of Exercise

Effects of Training

Strength Exercises

The Effect of Exercise on Metabolic Syndrome Components

Chronic Obstructive Pulmonary Disease and Metabolic Syndrome

Pelin Uysal1,*

Metabolic Syndrome

Definition

Chronic obstructive pulmonary disease (COPD)

Taxonomy

Risk factors

COPD AND COMORBIDITIES

Major Pulmonary Comorbidities

Major Extrapulmonary Comorbidities

Ischemic Heart Disease

Heart Failure

Hypertension

II- Metabolic disorders

Current Perspectives on Metabolic Syndrome and Cancer

Ravindri Jayasinghe1, Umesh Jayarajah1,* and Sanjeewa Seneviratne1

METABOLIC SYNDROME AND CANCER

Obesity and Cancer

Dyslipidemia and Cancer

Diabetes and Cancer

Hypertension and Cancer

PATHOPHYSIOLOGICAL BASIS OF METABOLIC SYNDROME AND CANCER

MECHANISMS INCREASING CANCER RISK

Hyperinsulinemia and Hyperglycemia

Role of Insulin and IGF 1

Estrogen Signaling

Role of Hormones and Proinflammatory Cytokines

Visceral Adiposity

Leptin

Adiponectin

Inflammatory Factors

IL-6

TNF- α

CRP

Transcription Factors

NF-kB

HIF-1α

PPARs

Other Factors

COX 2

MIF.

TYPES OF CANCERS LINKED.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Uzun, Hafize Metabolic Syndrome: a Comprehensive Update with New Insights

ISBN:

9789815322132

OCLC:

1485497026