Soft biological shells in bioengineering / Roustem N. Miftahof, Nariman R. Akhmadeev.

Format:

Book

Author/Creator:

Miftahof, Roustem, author.

Akhmadeev, Nariman R., author.

Contributor:

Institute of Physics (Great Britain), publisher.

Series:

IOP (Series). Release 6.

IOP expanding physics.

IPEM-IOP series in physics and engineering in medicine and biology

[IOP release 6]

IOP expanding physics, 2053-2563

Language:

English

Subjects (All):

Biomedical engineering.

Organs (Anatomy)--Mathematical models.

Organs (Anatomy).

Elastic plates and shells.

Biomedical Engineering.

Tissues.

Models, Theoretical.

Elasticity.

Medical Subjects:

Biomedical Engineering.

Tissues.

Models, Theoretical.

Elasticity.

Physical Description:

1 online resource (various pagings) : illustrations (chiefly color).

Edition:

1st ed.

Place of Publication:

Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2019]

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Biography/History:

Roustem N. Miftahof is a Professor, Dr. of Medicine and Applied Mathematics. Internationally acclaimed as a leading scientist in the fields of computational systems biology and medicine, Professor Miftahof has authored and co-authored six previous books in this field. Nariman R. Akhmadeev works as an Assistant Professor at the Department of Obstetrics and Gynecology at Kazan State Medical University, Russia. With an MD/MBBS degree and a PhD, he combines a career of academician and physician with a specific research interest in the application of mathematical and computational methods to his area.

Summary:

Soft Biological Shells in Bioengineeringintegrates existing experimental data to construct multiscale models of various organs of the human body--the stomach, gravid uterus, urinary bladder, the small and large intestine. These models are used asin silicoplatforms to study intricate physiological and pathophysiological processes and to assess pharmacological modulations on their dynamics. This book is of value to postgraduate students, researchers and medical doctors interested in computational systems biology. Part ofSeries in Physics and Engineering in Medicine and Biology.

Contents:

part I. Fundamentals of soft biological shells. 1. Geometry of the surface

1.1. Intrinsic geometry

1.2. Extrinsic geometry

1.3. Equations of Gauss and Codazzi

1.4. General curvilinear coordinates

1.5. Deformation of the surface

1.6. Equations of compatibility

2. Parameterization of shells of complex geometry

2.1. Fictitious deformations

2.2. Parameterization of the equidistant surface

2.3. A single function variant of the method of fictitious deformation

2.4. Parameterization of a complex surface in preferred coordinates

2.5. Parameterization of complex surfaces on a plane

3. Nonlinear theory of thin shells

3.1. Deformation of a shell

3.2. Forces and moments

3.3. Equations of equilibrium

4. Boundary conditions

4.1. Geometry of the boundary

4.2. Stresses on the boundary

4.3. Static boundary conditions

4.4. Deformations of the edge

4.5. Equations of Gauss-Codazzi for the boundary

5. Soft shells

5.1. Deformation of a soft shell

5.2. Principal deformations

5.3. Membrane forces

5.4. Principal membrane forces

5.5. Corollaries of the fundamental assumptions

5.6. Nets

5.7. Equations of motion in general curvilinear coordinates

5.8. Governing equations in orthogonal Cartesian coordinates

5.9. Governing equations in cylindrical coordinates

6. A continuum model of biological tissue

6.1. Histomorphology of tissue

6.2. A biocomposite as a mechanochemical continuum

6.3. Biofactor Zij

7. Neurons and neuronal assemblies

7.1. The intrinsic regulatory system in the gut

7.2. Interstitial cells of Cajal

7.3. Electrical activity in neurons

7.4. Neuronal circuits

8. Chemical synapse

8.1. A mathematical model

8.2. cAMP-dependent pathway

8.3. PLC-dependent pathway

8.4. Co-localization and co-transmission

9. Pharmacological modulations

9.1. Biological preliminaries

9.2. Modeling of competitive antagonist action

9.3. Modeling of allosteric interaction

9.4. Allosteric modulation of competitive agonist/antagonist action

9.5. Modeling of a PDE-5 inhibitor

part II. Applications. 10. The stomach

10.1. Anatomical considerations

10.2. Mechanical properties

10.3. Electromechanical phenomena

10.4. General model postulates

10.5. A functional unit

10.6. Co-transmission in the SIP-ganglion unit

10.7. The stomach as a soft biological shell

10.8. Gastric accommodation

10.9. The intrinsic regulatory system

11. The small intestine

11.1. Anatomical and physiological considerations

11.2. General model postulates

11.3. Investigations into intestinal smooth muscle

11.4. The intestine as a soft biological shell

11.5. Pharmacology of intestinal motility

12. The large intestine (colon)

12.1. Anatomical and physiological considerations

12.2. The colon as a soft biological shell

12.3. Pharmacology of colonic motility

13. The gravid uterus

13.1. Anatomical considerations

13.2. A functional unit

13.3. Electrophysiological properties

13.4. Neuroendocrine modulators

13.5. Coupling phenomena

13.6. Crosstalk phenomena

13.7. Biological changes in the gravid uterus

13.8. Modeling of the gravid uterus

13.9. General model postulates

13.10. Investigations into the myometrium

13.11. Co-transmission in the myometrium

13.12. The gravid uterus as a soft biological shell

13.13. Investigations into the gravid human uterus

14. The urinary bladder

14.1. Anatomical considerations

14.2. The detrusor

14.3. The neurohormonal regulatory system

14.4. Functional states in the bladder

14.5. Biomechanics of the detrusor

14.6. Models of the bladder

14.7. General model postulates

14.8. Investigations into the detrusor

14.9. Pharmacology of detrusor

14.10. The urinary bladder as a soft biological shell

14.11. Investigations into the urinary bladder

15. Conclusion.

Notes:

"Version: 20190701"--Title page verso.

Includes bibliographical references.

Title from PDF title page (viewed on August 15, 2019).

Description based on publisher supplied metadata and other sources.

ISBN:

9780750321945

0750321946

9780750321952

0750321954

OCLC:

1112388795