Liposomes : Advances in Research and Applications / edited by Usama Ahmad, Anas Islam.

Format:

Book

Contributor:

Ahmad, Usama, editor.

Islam, Anas, editor.

Series:

Pharmacology-research, safety testing, and regulation.

Pharmacology - Research, Safety Testing and Regulation Series

Language:

English

Subjects (All):

Liposomes.

Physical Description:

1 online resource (187 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"Liposomes: Advances in Research and Applications is a comprehensive exploration of the evolving landscape of liposome science. This meticulously crafted book encompasses a spectrum of topics, ranging from the historical context and versatile properties of liposomes to their recent developments and challenges in drug delivery. The book delves into the crucial role of liposomes in cancer therapy, examining the current state and outlining future directions, with a specific focus on breast cancer, cervical cancer, and ovarian cancer therapy. Furthermore, it explores the innovative applications of liposomes in gene delivery, providing insights into methods and real-world applications. As a cohesive resource, this book serves as an indispensable guide for researchers, clinicians, and students, offering a nuanced understanding of liposomal advancements and their potential in shaping the future of drug delivery, cancer treatment, and gene therapy"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

Liposomes: History, Properties, and Applications

Abstract

1. Introduction

1.1. Historical Development of Liposomes

2. Liposome Formation and Structure

3. Method of Liposome Preparation

3.1. Thin Film Hydration

3.2. Method of dispersion of Solvent

3.2.1. Ether Injection Method

3.2.2. Ether Injection

3.3. Reverse Phase Evaporation Method

3.4. French Pressure Cell: Extrusion

3.5. Sonication

3.6. Stability and Surface Charge

4. Types of Liposomes

4.1. Unilamellar liposomes (UV)

4.2. Multilamellar Liposomes

4.3. Small Unilamellar Vesicles (SUVs)

4.4. Large Unilamellar Vesicles (LUVs)

4.5. Giant unilamellar vesicles (GUVs)

4.6. Stealth Liposomes

5. Liposome Encapsulation Techniques

5.1. Encapsulation of Hydrophilic Drugs

5.2. Encapsulation of Hydrophobic Drugs

5.3. Active Loading and Passive Encapsulation Methods

6. Liposome Applications in Medicine

6.1. Drug Delivery Systems

6.2. Targeted Therapy and Site-Specific Drug Delivery

6.3. Liposomal Vaccines

6.4. Liposomes in Gene Therapy and Diagnostics

6.5. Liposomes in Cosmetics and Personal Care

6.6. Liposomes in Food and Nutraceuticals

6.7. Liposomes in Biotechnology and Research

7. Challenges and Future Directions

Conclusion

References

Chapter 2

Liposome-Mediated Drug Delivery: Recent Developments and Challenges

1.1. Advantages of Liposome-Mediated Drug Delivery Over Conventional and Other Pharmaceutical Delivery Systems

2. Liposome composition and design considerations

2.1. Liposome Composition

2.1.1. Lipid Components

2.1.2. Cholesterol

2.1.3. Other Lipid Additives

2.1.4. Surfactants

2.2. Surface Modification Strategies for enhanced drug delivery

2.2.1. PEGylation.

2.2.2. Ligand Targeting

2.2.3. Stealth Liposomes

2.3. Factors Affecting Drug Load and Release from Liposomes

2.4. Biocompatibility and Toxicity Considerations of Liposome Formulations

3. Recent developments in Liposome Technology

3.1. Heating Method

3.2. Combining Nanoprecipitation with Ionic Interaction

3.3. Novel Apparatus for Liposome Fabrication Based on Rapid Solvent Exchange

3.4. High-Shear Method for Liposome Preparation

3.4.1. Shearing with Glass Beads

3.5. Liposome Formation by Emulsification and Solvent Evaporation Technique

3.6. Packed Bed-Based Reactors

3.7. PVA Coating for Solid-State Liposome Formation

3.8. Spray drying for Liposome Preparation

3.9. Solvent Diffusion Methods

3.10. Supercritical Fluids

3.11. Microfluidics Approach

3.11. Pulsed Jet-Flow Microfluidic Method

3.12. Membrane Contactor

4. Challenges Associated with Liposome-Mediated Drug Delivery

4.1. Challenges

4.1.1. Low Drug Encapsulation Efficiency

4.1.2. Limited Drug Stability

4.1.3. Suboptimal Bio-Distribution

4.2. Approaches to Overcome Challenges in Liposome-Mediated Drug Delivery

4.2.1. Approach to Protect Physical Stability

4.2.2. Approach to Protect Chemical Stability

4.2.3. Large-Scale Production

4.2.4. In-Vivo Degradation

4.2.5. Economic Approach To Manufacturing Liposomes

4.3. Prospects of Liposome-Mediated Drug Delivery

Acknowledgments

Chapter 3

Liposomes in Cancer Therapy: Current State and Future Directions

2. Liposomes in Cancer Therapy

3. Different Pathways to Targeted Site for the Management of Cancer

3.1. AGEs RAGEs Pathways

3.2. Transforming Growth Factor-Beta (TGF-β) Pathway

3.3. Epidermal Growth Factor Receptor (EGFR) Pathway

3.4. Wnt/β-Catenin Signaling Pathway.

4. Strategies for Achieving Targeted Delivery of Liposomes to Cancer Sites

4.1. Enhanced Permeability and Retention (EPR) Effect and Its Application in Tumor Therapy

4.2. Active Targeting with Surface Engineered Liposomes

4.3. Targeting Overexpressed Receptors on the Surface of Cancer Cells

4.3.1. Targeting of Epidermal Growth Factor Receptor (EGFR)

4.3.2. Targeting of Folate Receptors (FRs)

4.3.3. Targeting of Transferrin Receptors (TfRs)

4.4. Tumor Microenvironments Targeting

4.4.1. Targeting of Vascular Cell-Adhesion Molecules (VCAMs)

4.4.2. Targeting of Integrins

4.4.3. Targeting of Matrix-Metalloproteases

4.4.4. Targeting of Cluster-of-Differentiation 44 (CD44)

5. Applications of Liposome-Based Drugs for Different Types of Cancer Therapy

6. Emerging Trends and Opportunities for Improving Liposome-Based Cancer Therapy

7. Current Challenges and Limitations of Liposome-Based Cancer Therapies

Chapter 4

Liposomes in Breast Cancer, Cervical Cancer and Ovarian Cancer Therapy: Recent Advancements and Future Perspectives

1.1. Liposome: A Brief Account

1.2. Liposomes in the Treatment of Breast Cancer

2. Receptor-Mediated Targeting of Breast Cancer

2.1. HER2 Receptor

2.2. Folate Receptors

2.3. Transferrin Receptors

2.4. Oestrogen Receptors

2.5. Integrin Receptors

2.6. VEGF Receptors

2.7. CD44 Receptors

3. Novel Liposome-Based Methods for Breast Cancer Therapy

3.1. Temperature-Sensitive Liposomes

3.2. pH-Sensitive Liposomes

4. Liposome in Gene Therapy for Breast Cancer

5. Liposome Formulation Approved for Breast Cancer Therapy

6. Liposomes in the Treatment of Cervical Cancer

7. Liposome in the Treatment of Ovarian Cancer

8. Challenges and Future Directions for Liposomal Preparation.

References

Chapter 5

Liposomes for Gene Delivery: Methods and Application

2. Fundamentals Characteristics of Liposomes

2.1. Structure of the Cell Membrane and Liposome

2.2. Interaction between Liposome Cell Membrane

2.2.1. Inter-Membrane Transfer

2.2.2. Absorption of Liposomes into Cell Membranes

2.2.3. Endocytosis of Liposomes in the Cell

2.2.4. Liposomes and Cell Membrane Fusion

2.3. Toxicity and Antigenicity

3. Preparation of Liposomes

3.1. Mechanical Dispersion Method

3.2. Solvent Dispersion Technique

3.3. Detergent Solubilisation Technique

4. Conventional Liposome Systems

4.1. Simple Liposomes

4.2. Cationic Liposomes

4.2.1. Delivery of the Cationic Nanolipoplex Gene with Divalent Cations

4.2.2. Transfer of Noncationic Nanolipoplex Gene with Divalent Cations

4.3. pH-Sensitive Liposome Strategy

4.3.1. The Vesicular Pathway for Cellular Uptake

4.4. Hemagglutinating Virus of Japan (HVJ or Sendai Virus)-Liposomes

4.4.1. Principles

4.4.2. In Vivo Transfection by HVJ-Liposome

4.4.3. Antisense Oligonucleotide Delivery

4.5. Liposome-Mediated Nucleic Acid Transfer

5. Prospects for Liposome-Mediated Gene Therapy

About the Editors

Index

Blank Page.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references and index.

ISBN:

9798891137004