Promising Cancer Therapeutic Drug Targets.

Format:

Book

Author/Creator:

Pandurangan, Ashok Kumar.

Language:

English

Physical Description:

1 online resource (287 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2025.

Summary:

Promising Cancer Therapeutic Drug Targets: Recent Advancements offers a comprehensive overview of novel and emerging strategies in cancer therapy. The book explores cutting-edge approaches such as exosomal delivery systems, CRISPR/Cas9 gene editing, and immunotoxins, alongside targeting mechanisms like cancer stem cells, apoptosis pathways, and key signaling processes. A strong emphasis is placed on the therapeutic potential of natural compounds in disrupting cancer progression and enhancing treatment response. Chapters are organized around molecular targets, therapeutic pathways, and bioactive agents to provide a clear, thematic structure. Key Features - In-depth exploration of CRISPR/Cas9, exosomes, and stem cell-targeted therapy - Focus on natural compounds in cancer treatment - Insights into key signaling pathways (Hippo, Hedgehog, STAT3) - Discussion on apoptosis and drug resistance mechanisms.

Contents:

Intro

Title

Copyright

End User License Agreement

Contents

Preface

List of Contributors

Exosomal Delivery of CRISPR/CAS9 Assembly: Approach towards Cancer Therapeutics

Kaumudi Pande1,2,#, PP Mubthasima1,2,#, Rajalakshmi Prakash1,2,# and Anbarasu Kannan1,2,*

INTRODUCTION

CRISPR AS A POTENTIAL THERAPEUTIC AGENT FOR METASTASIS

Molecules Involved in Metastasis

Metastatic Molecules Targeted by CRISPR/Cas9 System

EXOSOMES AS A POTENTIAL CARRIER (THERAPEUTIC CARRIER): EXOSOMES-BASED DELIVERY OF SMALL MOLECULES, BIOACTIVE MOLECULES, SIRNA

GREAT BEGINNING OF THE CRISPR/CAS SYSTEM IN HUMAN TRIALS

DIFFERENT DELIVERY SYSTEMS FOR CRISPR/CAS

EXOSOMAL-BASED DELIVERY FOR CRISPR

CONCLUSION

FUTURE PERSPECTIVE

REFERENCES

Cancer Stem Cells and Their Role in Chemo-Resistance

Vaishali Ji1, Chandra Kishore2,* and Krishna Prakash3

Normal Stem Cells and Cancer Stem Cells Linked to Carcinogenesis

Transporter Proteins in Stem Cells and Cancer

Chemotherapy Resistance in Cancer and Cancer Stem Cells

Controlling Drug-Resistant Cancer Cells

Cell Signaling in Cancer Stem Cells Cancer Therapy

Importance of Natural Compounds Targeting the Mitophagic Process in Breast Cancer Treatment

Prathibha Sivaprakasam1, Karthikeyan Chandrabose2, Sureshkumar Anandasadagopan3, Hariprasth Lakshmanan4 and Ashok Kumar Pandurangan1,*

Breast Cancer Statistics

Breast Cancer and Indian Scenario

Mitophagy

Mitophagy and Cancer

Mutations in PARK2 (Parkin)

Mitophagy Mediated by HIF1α - BNIP3, NIX, and FUNDC1

HIF1α and the Tumor Microenvironment

BNIP3 and NIX in Cancer Mitophagy

FUNDC1 in Cancer Mitophagy

KRAS Mutations and Cancer Mitophagy

Biological Role of Mitophagy.

Manipulating Mitophagy as a Potential Target for Cancer Therapy

Induction of Mitophagy Increases Cancer Cell Death and Chemotherapy Sensitivity

Inhibition of Mitophagy Enhances Drug Sensitivity

Classical Inhibitors of Mitophagy

Novel Inhibitors of Mitophagy

Role of Natural Compounds in Mitophagy

Withaferin

Curcumin

Gingerol

Thymoquinone

Artepillin C

Cucurbitacin B

Triptolide

Allicin

Jolkinolide B

Chalocomoracin

AUTHOR'S CONTRIBUTION

Bioactive Natural Compounds as Inhibitors of Signal Transducer and Activator of Transcription 3: Prospects in Anti-Cancer Therapeutics

Praveen Deepak1,*

THERAPEUTIC TARGETING OF STAT3 SIGNALING IN CANCER

Targeting of STAT3 to Prevent Activation

Targeting Protein-Protein Interactions in the STAT3 Signaling Pathway

Targeting Nuclear Translocation of STAT3

Targeting Binding of STAT3 to the Promoter Region of DNA

TARGETING STAT3 BY NATURAL BIOACTIVE COMPOUNDS

Polyphenols as Inhibitors of STAT3

Flavonoids as STAT3 Inhibitors

Flavones in the Regulation of STAT3

Flavanones in the Regulation of STAT3

Flavanol in the Regulation of STAT3

Flavonol in the Regulation of STAT3

Anthocyanidin in the Regulation of STAT3

Isoflavonone as STAT3 Inhibitors

Chalcones as STAT3 Inhibitors

Other Polyphenols Targeting STAT3

Non-Polyphenolic Compounds as Inhibitors of STAT3

ACKNOWLEDGEMENTS

Targeting Cancer Stemness by Exosomes as a Therapeutic Approach against Ovarian Cancer

Kaumudi Pande1,2 and Anbarasu Kannan1,2,*

MECHANISM OF CANCER STEM CELLS LEADING TO OVARIAN CANCER AND ITS METASTATIC SITES

MITOCHONDRIAL &amp

EMT MECHANISMS ON OVARIAN CANCER AND ITS METASTATIC SITES

NATURAL AND SMALL MOLECULES TARGETING OVARIAN CANCER.

EXOSOMES-BASED DELIVERY OF DRUGS AND OTHER MOLECULES TARGETING OVARIAN

LIST OF ABBREVIATIONS

Sphingosine Kinase as a Target to Treat Gastrointestinal Cancers

Mit Joshi1 and Bhoomika M. Patel2,*

Currently Available Therapies to Treat Gastrointestinal Cancer

Sphingolipid Metabolism

Sphingolipid Enzymes

Sphingosine Kinases

Ceramidase

Glucosylceramide Synthase

Ceramide Synthase

Importance of Ceramide

Role of S1P in the Growth of Cancer and Metastasis

S1P Receptors

Presence of Sphingolipids in the Digestive System

Metabolism of Sphingolipids in the Gastrointestinal Tract

Sphingolipids and Colorectal Tumorigenesis

Sphingolipids and Intestinal Inflammation

Sphingolipids in Liver Cancer

Hippo Signaling and its Regulation in Liver Cancer

Naveen Kumar Perumal1, Vasudevan Sekar2, Annapoorna Bangalore Ramachandra2,3, Nivya Vijayan2,3, Vani Vijay2,3, Venkat Prashanth2,3 and Madan Kumar Perumal2,3,*

Hippo Pathway

The Mammalian Hippo Pathway

Hippo Pathway in Cancer

Hippo Pathway in Liver Cancer

Association of Hippo and Tumor-Related Pathways

Hippo and Wnt Pathway

Hippo and TGF-β Pathway

Hippo and other Pathways

Role of Hippo Signaling in Liver Cancer Development

Role of Key Proteins in Regulating Hippo Pathway

Role of Mst1 in Liver Cancer

Effects of Targeting Mst1 Protein During Liver Carcinogenesis

Role of YAP in Liver Cancer

Effect of Targeting Yap Protein During Liver Carcinogenesis

Role of LATS 1/2 in Liver Cancer

Effects of Targeting LATS1 and LATS2 Protein During Liver Carcinogenesis

Immunotoxin: A New Generation Agent for Cancer Treatment.

Subha Ranjan Das1, Dibyendu Giri1, Tamanna Roy1, Surya Kanta Dey1, Rumi Mahata1, Angsuman Das Chaudhuri1, Suman Mondal1 and Sujata Maiti Choudhury1,*

Mechanism of Action

Diptheria Toxin (DT)

Pseudomonas Exotoxin A

Immunoconjugates for Cancer Therapy

Antibody-drug Conjugates

Radioimmunoconjugates (RICs)

The Antibody as a Targeting Moiety

Ligand as a Target and Cytokine Receptor as a Targeting Moiety

Growth Factor Receptors as Targets

Targeting Antigens Associated with Tumors

HER2 Specific Immunotoxins

Immunotoxins Against Hepatocellular Carcinoma (HCC)

Immunotoxin Therapy for Lung Cancer

Immunotoxins for Leukemia

Immunotoxins for Colorectal Cancer Therapy

Immunotoxin Therapy of Glioblastoma

Multifactorial Drug - A Revolution in the Treatment of Cancer by Inhibiting Hedgehog Pathway

M. Santosh Kumar1,*, Poornima D. Vijendra2, Pratap G. Kenchappa1 and A. Gowtami1

CANCER AND HH PATHWAY

HEDGEHOG SIGNALING AND HUMAN DISEASES

Type I- Ligand-Independent Hedgehog Signaling

Type II- Ligand-Dependent Autocrine/Juxtacrine Signalling

Type IIIa/b: Ligand-Dependent Hh Signaling in Paracrine Manner

HH SIGNALING PATHWAY TARGETS AND MULTIFACTORIAL DRUGS

Inhibitors of Hedgehog Pathway

Promising Natural Agents for Targeting Micro-RNAs in Cancer

Rumi Mahata1, Subhabrata Das1, Suman Mondal1, Surya Kanta Dey1, Anirban Majumder1 and Sujata Maiti Choudhury1,*

miRNA Synthesis

MicroRNA (miRNAs) in the Development of Tumorigenesis and Carcinogenesis

Modulation of miRNA Expression in Cancer Using Phytocompounds

Resveratrol

Berberine

Indole-3-Carbinol (I3C)

Quercetin

Epigallocatechin-3-Gallate (EGCG)

Genistein.

Paclitaxel

Betulinic Acid (BA)

Oleanolic Acid

Camptothecin

Vincristine

Understanding the Mechanism of Targeted Therapy- The Next Generation for Cancer Treatment

K.R. Padma1,*, K.R. Don2 and P. Josthna1

ROLE OF NATURAL PRODUCTS IN CHEMOTHERAPY

NEW CANCER THERAPIES BASED ON BIO-TARGETS

UNDERSTANDING THE MECHANISM OF REPURPOSED DRUGS IN THE TREATMENT OF CANCER

IMMUNOGENICITY OF MONOCLONAL ANTIBODIES

CUTTING-EDGE IN CANCER THERAPY

CONTRIBUTIONS

Cell Death Apoptotic Pathways and Targeted Therapeutic Research in Cancer

Jutishna Bora1,#, Richismita Hazra2,# and Sumira Malik1,*

MECHANISM OF CELL DEATH

APOPTOSIS AND CANCER

APOPTOSIS AND CANCER THERAPY

PLANT-DERIVED COMPOUNDS EXHIBITING ANTI-CANCEROUS ACTIVITY

Apoptosis Defects in Cancer and its Therapeutic Implications

Jutishna Bora1,#, Sayak Banerjee2,#, Indrani Barman3, Sarvesh Rustagi4, Richa Mishra5 and Sumira Malik1,*

APOPTOTIC DEFECTS AND CANCER

Defects in Caspase Signaling

Defects in Intrinsic Pathways

Defects in Extrinsic Pathways

POTENTIAL LIMITED ROLE OF APOPTOTIC CELL DEATH

TARGETED THERAPIES AND CANCER

Targeting Anti-apoptotic Bcl-2 Family Members

Mcl-1 Inhibitors

XIAP Inhibitors

Caspase Activators in Cancer Therapy

Subject Index.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Pandurangan, Ashok Kumar Promising Cancer Therapeutic Drug Targets: Recent Advancements

ISBN:

9789815238570

OCLC:

1526859420