Advancements in Cancer Research.

Format:

Book

Author/Creator:

Bhattacharya, Sankha.

Contributor:

Sharma, Mayank.

Page, Amit B.

Language:

English

Physical Description:

1 online resource (328 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2025.

Summary:

Advancements in Cancer Research: Exploring Diagnostics and Therapeutic Breakthroughs is a comprehensive resource that highlights the latest innovations in cancer research. This book bridges the gap between cutting-edge science and clinical applications, offering insights into the molecular mechanisms, diagnostic advancements, and novel therapeutic strategies revolutionizing cancer care.Organized into thematic sections, the book explores critical areas such as molecular biomarkers, immunotherapy, nanotechnology in diagnostics and treatment, and targeted therapies. Topics include the role of TP53 mutations in colorectal cancer, nanocarriers for melanoma therapy, RNA-based therapeutics for colon cancer, and biomaterials for bone tumor management. Readers will also discover how emerging technologies like nanotheranostics and transethosomes are paving the way for personalized cancer care. Key Features:- Insights into molecular and nanotechnology-driven cancer therapies.- Exploration of diagnostics and biomarker applications.- Multidisciplinary approaches to advancing patient care.- Analysis of current trends and prospects in oncology. Readership: Medical researchers, oncologists, healthcare professionals, biomedical science students, and anyone committed to the fight against cancer.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

Acknowledgements

List of Contributors

Exploring the Horizon of Cancer Research: Pioneering Breakthroughs in Diagnostics and Theranostics

Sankha Bhattacharya1,* and Darshan Bhirud1

INTRODUCTION

THE GENOMIC AND PROTEOMIC LANDSCAPE: A PARADIGM SHIFT IN CANCER DIAGNOSTICS

BEYOND CONVENTIONAL IMAGING: MOLECULAR AND FUNCTIONAL IMAGING

TARGETED THERAPIES AND PRECISION ONCOLOGY

CONVERGENCE OF DIAGNOSTICS AND THERAPEUTICS: THERANOSTICS

BIG DATA ANALYTICS: MINING INSIGHTS FROM COMPLEX ONCOLOGICAL DATASETS

COLLABORATIVE RESEARCH INITIATIVES DRIVING PROGRESS

THE NEXT ERA OF CANCER RESEARCH AND PATIENT CARE

BRIDGING BASIC RESEARCH AND CLINICAL PRACTICE

PRECISION ONCOLOGY

THERANOSTICS-COMBINING THERAPY AND DIAGNOSTICS

CLINICAL IMPACT OF EMERGING CANCER RESEARCH

CHALLENGES AND FUTURE DIRECTIONS

CONCLUSION

REFERENCES

TP53 Gain-of-Function Mutation and High-Methylation Status: Unveiling a Bleak Prognostic Molecular Subset in Metastatic Colorectal Cancer

TP53 AND METHYLATION IN THE TRICOLORE STUDY

Understanding TP53 Mutations in mCRC

DNA Methylation and its Role in Cancer

Interplay Between TP53 Mutations and DNA Methylation

Implications for Prognosis and Therapeutic Strategies

Future Directions and Research Opportunities

TP53 MUTATIONS AND METHYLATION DYNAMICS IN MCRC

TP53 MUTATION SUBTYPES AND THEIR IMPACT ON TREATMENT RESPONSE

COMPARISON OF SURVIVAL OUTCOMES BETWEEN HIGH-METHYLATED AND LOW-METHYLATED COLORECTAL CANCER

SUBGROUP ANALYSES UNRAVEL THE PUZZLE OF PROGNOSIS

INDEPENDENT METHYLATION IN CRC PROGNOSIS

PROGNOSTIC IMPLICATIONS OF TP53 GOF MUTATIONS AND HYPERMETHYLATION IN METASTATIC COLORECTAL CANCER.

DISCUSSION

FUTURE DIRECTIONS AND IMPLICATIONS FOR PERSONALIZED TREATMENT STRATEGIES

CD105 in the Progression and Therapy of Colon Cell Carcinoma

Sankha Bhattacharya1,*

COLON CELL CARCINOMA AND THE ROLE OF CD105

BIOLOGICAL FUNCTION AND ROLE OF CD105

DECIPHERING THE TALE OF CD105 EXPRESSION IN COLON CANCER

CD105'S IMPACT ON COLON CANCER PROGRESSION

CD105'S DUAL DANCE OF ANGIOGENESIS AND METASTASIS IN COLON CANCER

INTEGRATING CD105-TARGETED THERAPIES INTO CANCER TREATMENT FRAMEWORKS

STRATEGIES FOR TARGETING CD105 IN COLON CANCER THERAPY

DISMANTLING CD105'S GRIP ON COLON CANCER

CD105 AND THE EVOLVING LANDSCAPE OF COLON CANCER

CD105 as a Biomarker

CD105 SIGNALING PATHWAYS AND THEIR IMPACT ON CANCER PROGRESSION

POTENTIAL ROLE OF CD105 IN MEDIATING TREATMENT RESISTANCE IN COLON CELL CARCINOMA

LIMITATIONS AND FUTURE RESEARCH

The Significance of N-Glycolylneuraminic Acid as a Carbohydrate Biomarker in Cancer Progression and Therapy

N-GLYCOLYLNEURAMINIC ACID'S DANCE WITH CANCER

DECIPHERING THE NEU5GC'S CRUCIAL ROLE IN CANCER DIAGNOSIS, PROGNOSIS, AND TREATMENT STRATEGIES

MECHANISTIC INSIGHTS INTO NEU5GC-MEDIATED EFFECTS

A SYMPHONY OF TECHNIQUES FOR NEU5GC DETECTION AND QUANTIFICATION

The Power of Mass Spectrometry

The Enchantment of Immunoassays

The Orchestral Chorus of Spectroscopy

Case Study

NEU5GC'S WHISPERS OF TUMOR CHARACTERISTICS

A Tapestry of Correlations: Neu5Gc and Tumor Type and Grade

A Waltz with Metastasis: Unveiling the Dance of Spread

A Symphony of Resistance: Neu5Gc and Treatment Response

NEU5GC WITH A SYMPHONY OF TECHNIQUES

The Ensemble of Detection Techniques

Mass Spectrometry (MS).

Immunoassays

Spectroscopy

CHALLENGES AND ADVANCES

COMPARATIVE ASSESSMENT: NEU5GC VS. OTHER CARBOHYDRATE BIOMARKERS

NEU5GC AS THE CONDUCTOR OF PERSONALIZED CANCER THERAPY

A Precision Overture: Neu5Gc as a Target for Tailored Therapies

A Symphony of Therapeutic Strategies

Antibody-Drug Conjugates (ADCs)

Inhibitors of Neu5Gc Biosynthesis

Vaccination Strategies

A Hopeful Finale: Personalized Cancer Treatment on the Horizon

THE FUTURE OF NEU5GC RESEARCH

Unexplored Verses: Untapped Areas of Neu5Gc Inquiry

A Heterogeneous Harmony: Implications of Neu5Gc Variability

From Crescendo to Chorus: Translational Barriers and Opportunities

From Forgotten Melody to Hopeful Conductor of Cancer Treatment

A Spotlight on Early Detection

Tailoring the Orchestration: Neu5Gc and Precision Medicine

STATISTICAL EVIDENCE SUPPORTING NEU5GC AS A RELIABLE BIOMARKER (2023-2024)

Nanoparticles for Advancing Cancer Metastases, Diagnosis, and Treatment: Current Progress and Prospective Avenues

BRIDGING THE ORGANIC-INORGANIC SPECTRUM AND MASTERING SURFACE PRECISION

PRECISION THERAPEUTICS AND ILLUMINATED DIAGNOSTICS

MECHANISMS OF NANOPARTICLES IN OVERCOMING BIOLOGICAL BARRIERS FOR ENHANCED DRUG DELIVERY

LIQUID BIOPSY, EXOSOMES, NANOPARTICLES, AND TARGETED THERAPY IN THE BATTLE AGAINST METASTATIC CANCER

NANOPARTICLES IN METASTATIC CANCER

PRECISION WARFARE WITH ACTIVE AND PASSIVE TARGETING STRATEGIES AGAINST METASTATIC TUMORS

NANOPARTICLES BREACH THE BIOLOGICAL BARRIERS OF METASTASIS

INTEGRATING IMAGING AND THERAPY WITH THERANOSTIC NANOPARTICLES

UNLEASHING THE FULL POWER OF THERANOSTIC NANOPARTICLES.

A GLIMPSE INTO THE FUTURE OF CANCER THERAPY

REGULATORY FRAMEWORKS

ETHICAL CONSIDERATIONS

CURRENT TRENDS AND FUTURE DIRECTIONS

Recent Advances in Nanotechnology for The Diagnosis and Therapy of Melanoma Skin Cancer

Abhishek Kanugo1,*

Types of Skin Cancer

Melanoma Skin Cancer (MSC)

Non-Melanoma Skin Cancer (NMSC)

The Barrier to Skin Carcinoma

Diagnosis of Skin Cancer

NANOTECHNOLOGY-BASED APPROACHES

Lipid-based Approaches

Liposomes

Solid Lipid Nanoparticles (SLN)

Nanostructured Lipid Carrier (NLC)

Vesicle-based Approaches

Niosomes

Ethosomes

Other Vesicular Carriers

INTEGRATION OF NANOTECHNOLOGY WITH BIOINFORMATICS AND OTHER DISCIPLINES FOR ENHANCED SKIN CANCER TREATMENT

NANOTECHNOLOGY IN SKIN CANCER TREATMENT

ROLE OF BIOINFORMATICS IN ENHANCING NANOTECHNOLOGY APPLICATIONS

SYNERGY WITH GENOMICS AND MOLECULAR BIOLOGY

APPLICATIONS IN DIAGNOSTICS AND THERANOSTICS

ECONOMIC CONSIDERATIONS OF IMPLEMENTING NANOTEC- HNOLOGY IN SKIN CANCER TREATMENT: BENEFITS AND COSTS

Applications of Advanced Nanocarriers in the Theranostics of Melanoma Skin Cancer

POLYMER-BASED APPROACHES

Polymeric Micelles (PMs)

Dendrimers

Hydrogel

NANOPARTICLE (NP)-BASED APPROACH

CARBON-BASED NANOCARRIERS

Carbon Nanotubes (CNTs)

Graphene Oxide (GO)

Nanofibers (NFs)

MICRONEEDLE TECHNIQUE

CLINICAL TRIALS (CT)

BIOCOMPATIBILITY AND TOXICITY OF NANOCARRIERS IN THE THERANOSTICS OF MELANOMA IN SKIN CANCER

Recent Advances in Immunotherapy-Based Approaches for the Therapy of Melanoma Skin Cancer

Abhishek Kanugo1,* and Rutik Juktee2

Immunotherapy

Immune Checkpoint Inhibitors (ICIs).

Adoptive T Cell Transfer (ATCT), CAR-T, and TCR-Engineered T Cell

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

IFN- γ

Tumor Necrosis Factor-Alpha (TNF-α)

VACCINE THERAPY

Gp-100 Vaccine

IDO-Peptide Vaccine

6-Melanoma Helper Peptide Vaccine

Oncolytic Virus Therapy

PATIENT-SPECIFIC FACTORS IN OPTIMIZING IMMUNOTHERAPY FOR MELANOMA

RECENT ADVANCEMENTS AND FUTURE DIRECTIONS IN MELANOMA SKIN CANCER TREATMENT

LONG-TERM IMPACT ON QUALITY OF LIFE IN PATIENTS AND TREATMENT OUTCOMES IN MELANOMA BY IMMUNOTHERAPY

Update on Applications of Nanotheranostics for the Management of Cancer

Jayesh Patil1, Datta Maroti Pawde1,*, Sankha Bhattacharya1,* and Rehanoddin Shaikh1

APPLICATIONS OF NANOTHERANOSTICS FOR THE DIAGNOSIS OF CANCER

X-ray CT Imaging

Magnetic Resonance Imaging

Optical Imaging

Ultrasound Imaging

PET Imaging

APPLICATIONS OF NANOTHERANOSTICS FOR THE TREATMENT OF CANCER

Photodynamic Therapy

Photothermal Therapy

Chemotherapy

DIAGNOSTIC AND THERAPEUTIC APPLICATIONS OF NANODIAGNOSTICS AND NANOTHERANOSTICS IN CANCER MANAGEMENT

CHALLENGES IN THE APPLICATION OF NANOTHERANOSTIC FOR THE MANAGEMENT OF CANCER

POSSIBLE SIDE-EFFECTS AND LONG-TERM EFFECTS OF NANOMATERIALS IN NANOTHERANOSTICS FOR CANCER MANAGEMENT

CASE STUDIES ILLUSTRATING THE PRACTICAL EFFECTIVENESS OF NANODIAGNOSTICS IN NANOTHERANOSTICS FOR CANCER MANAGEMENT

Breast Cancer Detection and Treatment

Prostate Cancer Imaging and Therapy

Pancreatic Cancer

Glioblastoma Treatment

FUTURE PERSPECTIVE

Biomaterials for Bone Tumor: Present and Future Trends in Control and Treatment Strategy

Saurav Patil1, Dhrubojyoti Mukherjee1,* and Sankha Bhattacharya1

INTRODUCTION.

SCAFFOLDS AND COMPOSITE MATERIALS IN BONE TUMOR AND BONE TISSUE REGENERATION.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9789815305906

9815305905

OCLC:

1507698341