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Current Topics on Renal Dysfunction.
- Format:
- Book
- Author/Creator:
- Valdez-Ortiz, Rafael.
- Language:
- English
- Subjects (All):
- Nephrology.
- Kidneys--Diseases.
- Kidneys.
- Physical Description:
- 1 online resource (314 pages)
- Edition:
- 1st ed.
- Place of Publication:
- Sharjah : Bentham Science Publishers, 2025.
- Summary:
- With renal dysfunction affecting millions worldwide, this book presents a timely and integrative look at emerging insights--from molecular foundations to clinical management. It explores the intricate mechanisms, systemic impact, and clinical complexities of kidney diseases in a multidisciplinary context. Spanning a broad spectrum of conditions, the book addresses renal tubular acidosis, polycystic kidney disease, renal lithiasis, diabetic kidney disease, and sodium imbalance-linked hypertension. Chapters delve into nephrotoxicity, loss of cellular identity in renal carcinoma, epigenetics, dysbiosis, and the evolving role of SGLT2 inhibitors. The book also highlights innovative approaches such as stem cell therapy and the systemic immune interactions that underlie chronic kidney injury. Key Features: Examines genetic and epigenetic underpinnings of renal disease Explores microbiota and immune system crosstalk in kidney pathology Discusses both acute and chronic conditions with clinical relevance Integrates foundational science with translational perspectives Includes emerging therapies and precision medicine approaches.
- Contents:
- Intro
- Title
- Copyright
- End User License Agreement
- Contents
- Foreword
- Preface
- List of Contributors
- Metabolism in Kidney Disease
- Azalia Ávila-Nava1, Isabel Medina-Vera2 and Consuelo Plata3,*
- INTRODUCTION
- FATTY ACID OXIDATION (FAO)
- GLUCOSE METABOLISM
- AMINO ACID METABOLISM
- METABOLIC CHANGES IN KIDNEY DISEASE
- CONCLUSION
- REFERENCES
- The Role of Mitochondria and Oxidative Stress in Renal Disease
- Ana Carolina Ariza1 and Consuelo Plata2,*
- MITOCHONDRIA AND OXIDATIVE STRESS
- MECHANISMS LEADING TO OXIDATIVE STRESS IN AKI AND CKD
- MITOCHONDRIAL FUNCTION AND RENAL DAMAGE
- SIRTUINS AND OTHER THERAPEUTIC TARGETS IN AKI
- Structure
- Dynamics
- Biogenesis
- Reactive Oxygen Species (ROS)
- Mitochondrial Permeability Transition Pore (mPTP)
- ACKNOWLEDGMENTS
- Inflammation in Kidney Diseases
- Azalia Ávila-Nava1, Nayeli Goreti Nieto-Velázquez2 and Isabel Medina-Vera3,*
- Inflammation: Acute Kidney Injury to Chronic Kidney Disease Progression
- Etiology and Outcomes of Inflammation in CKD
- Role of Proinflammatory Biomarkers in Renal Injury
- Anti-inflammatory Therapies in CKD: Diet Bioactive Compounds, Prebiotics, Probiotics Use, and Intradialytic Exercise
- Metabolic Syndrome as a Risk Factor for Chronic Kidney Disease
- Ana Ligia Gutiérrez-Solís1,2,* and Nina Mendez-Domínguez1
- PATHOPHYSIOLOGY OF METS COMPONENTS IN CKD
- DIAGNOSIS OF METS IN PATIENTS WITH CKD
- TREATMENT OF METS IN PATIENTS WITH COEXISTING CKD
- Current Definitions, Biomarkers, and Treatments for Acute Kidney Injury
- Juan Carlos Diaz Núñez1 and Rafael Valdez Ortiz1,*
- EPIDEMIOLOGY
- ETIOLOGY
- DIAGNOSIS
- TREATMENT
- REFERENCES.
- Non-Anion Gap Metabolic Acidosis: Renal Tubular Acidosis
- Juan Reyna-Blanco1,*
- PHYSIOLOGY OF ACID-BASE BALANCE
- Acid-base Balance in Proximal Tubules and Ammonia Genesis
- Acid-base Balance in the Distal Nephron
- Classification of Renal Tubular Acidosis
- Proximal Renal Tubular Acidosis (type 2)
- Distal Renal Tubular Acidosis (Type 1)
- Hyperkalaemic Renal Tubular Acidosis (Type 4)
- Approach and Diagnosis of Renal Tubular Acidosis
- Urine Anion Gap (UAG)
- Urine Osmolality (UOG)
- Urine pH
- Citrate Excretion
- Urine PCO2
- Sodium Bicarbonate Loading Test
- Acid Loading Test
- Proximal Renal Tubular Acidosis
- Distal Renal Tubular Acidosis
- Hyperkalemic Renal Tubular Acidosis
- The Genetic Structure of Polycystic Kidney Disease (PKD)
- Cristino Cruz1, Claudia J. Bautista2 and Victoria Ramírez3,*
- ADPKD
- ARPKD
- Reported Mutations
- GENETICS OF PKD DISEASE
- PKD1
- PKD2
- PKHD1
- New Genes involved in PKD
- PATHOPHYSIOLOGY
- Molecular Mechanisms
- CURRENT NOVEL STUDIES AND TREATMENT
- Renal Lithiasis: Current Concepts about a Millenary Disease
- Roberto Lugo1,* and Martha Medina-Escobedo1
- PHYSIOPATHOLOGY
- TYPES OF KIDNEY STONES
- RISK FACTORS FOR RENAL DISEASE IN LITHIASIS
- DIAGNOSTIC METHODS
- Clinical History of Renal Lithiasis
- Diagnoses by Imaging
- Methods to Determine the Stone Composition
- CURRENT STUDIES OF RENAL LITHIASIS
- TREATMENT OF KIDNEY STONES
- FUTURE PERSPECTIVES
- Sodium Imbalance and Hypertension: An Old and Current Disease
- Mercedes Aguilar-Soto1 and Fabio Solis-Jiménez2,*
- CURRENT AND NOVEL STUDIES (THE STATE OF THE ART)
- CONCLUSION.
- REFERENCES
- Diabetic Kidney Disease: A Versatile Disease
- María De Los Ángeles Granados-Silvestre1, Guadalupe Ortiz-López1 and Katy Sánchez-Pozos1,*
- Biomarkers
- Genetic Variants Associated with DKD
- Transcriptomics
- Epigenetics
- The Nephrotoxicity by Chemicals
- Estefani Yaquelin Hernández-Cruz1,2, Estefany Ingrid Medina-Reyes1 and José Pedraza-Chaverri1,*
- Clinical Renal Syndromes
- Acute Kidney Injury
- Tubulopathies
- Protein Disease
- Chronic Kidney Disease
- Molecular Mechanisms Associated with Nephrotoxins
- Loss of Cellular Differentiation in Renal Carcinoma
- Jazmin Marlen Pérez-Rojas1,*
- PATHOPHYSIOLOGY OF RCC
- Classification
- Risk Factors
- Hypertension
- Obesity and Dyslipidemia
- Genetics
- Surgery
- Immunotherapy
- Chemotherapy and Radiotherapy
- Other Therapies
- Epigenetics in Renal Diseases
- Karina Robledo-Márquez1, Yadira Ramírez2 and Joyce Trujillo3,*
- PATHOPHYSIOLOGY, CURRENT AND NOVEL STUDIES
- DNA Methylation and Demethylation
- Chromatin Structure Modifications
- Histone Modifications
- Acetylation
- Methylation
- Crotonylation
- Non-coding RNAs
- EPIGENETICS IN DIAGNOSIS
- From Stem Cells to One Functional Kidney
- Ana Laura Calderón-Garcidueñas1,*
- TYPES OF CELLS IN THE HUMAN BODY
- EMBRYOLOGY
- VASCULAR ORGANIZATION
- SIGNALING PATHWAYS AND REGENERATIVE PROCESS
- PI3K/AKT/mTOR Pathway
- JAK/STAT
- Wnt-GSK3-β-Catenin Pathway
- MAPK/ERK Pathway.
- THE LONG ROAD TO A FUNCTIONAL KIDNEY
- Xenotransplantation of Adult Organs or Embryonic Tissues
- Chimeras
- Blastocyst Complementation
- Targeted Organ Complementation
- Stem Cell-Based Therapies
- Whole-Kidney Grafts
- Fetal Kidney-Derived Cells
- Pluripotent Stem Cells
- Mesenchymal Stem Cells
- Renal Progenitor Cells
- Organ Bioengineering
- Bioartificial Kidney
- Kidney-Derived Scaffolds
- Self-Organizing Nephrons
- Kidney Organoids
- Kydney-on-A-Chip
- Glomerulus-on-A-Chip
- Tubule-on-A-Chip
- 3D&
- 4D Bioprinting
- WHAT IS REQUIRED TO GENERATE A COMPLETE KIDNEY?
- Pleiotropic Effects of Renal Disease Management: Role of SGLT2 Inhibitors
- Iván Calderón-Lojero1, Rafael Valdez-Ortiz2 and Katy Sánchez-Pozos1,*
- CARDIOPROTECTIVE EFFECTS
- Blood Pressure
- PANCREATIC PROTECTIVE EFFECTS
- HEPATOPROTECTIVE EFFECTS
- NEUROPROTECTIVE EFFECTS
- RENOPROTECTIVE EFFECTS
- ADVERSE EVENTS OF SGLT2I
- Dysbiosis in Acute Kidney Injury and Chronic Kidney Disease
- Laura Elena Zamora- Cervantes1 and Enzo Christopher Vásquez- Jiménez1, *
- Epidemiology of AKI and CKD
- Microbiome and its Functions
- Altered Pathways in AKI and CKD
- Role of Dysbiosis in Kidney Disease
- Dysbiosis and Progression Mechanisms of AKI and CKD
- Hypoxia
- Mitochondrial Axis
- Cellular Imbalance
- Uremic Toxins
- Alternatives for Reestablishing the Microbiome Homeostasis
- Subject Index.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Part of the metadata in this record was created by AI, based on the text of the resource.
- ISBN:
- 981-5305-69-7
- OCLC:
- 1532833777
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