Model-based approaches in biomedical engineering / Ean Hin Ooi and Yeong Shiong Chiew.

Format:

Book

Author/Creator:

Ooi, Ean Hin, author.

Chiew, Yeong Shiong, author.

Series:

IPEM-IOP Series in Physics and Engineering in Medicine and Biology Series

Language:

English

Subjects (All):

Biomedical engineering--Computer simulation.

Biomedical engineering.

Physical Description:

1 online resource (305 pages)

Edition:

First edition.

Place of Publication:

Bristol, England : IOP Publishing, [2023]

Summary:

This practical guide explores the application of modelling in biomedical engineering and healthcare. The book uses a careful selection of topics that showcase the role of computational modelling in biomedical engineering.

Contents:

Intro

Preface

Acknowledgments

Editor biographies

Ean Hin Ooi

Yeong Shiong Chiew

Foreword

Chapter 1 Introduction

1.1 Early developments of biomedical engineering

1.2 Modelling in biomedical engineering

1.3 Modelling approaches in biomedical engineering

References

Chapter 2 Mechanistic modelling

2.1 Background

2.2 Fundamentals of mechanistic modelling

2.2.1 Problem definition

2.2.2 Geometrical model

2.2.3 Mathematical model

2.2.4 Simulation

2.2.5 Post-processing

2.3 Ocular heat transfer: an illustrative example

2.3.1 Problem definition

2.3.2 Geometrical model

2.3.3 Mathematical model

2.3.4 Simulation

2.3.5 Post-processing

2.4 Important considerations in mechanistic modelling

2.5 Summary

Chapter 3 Review of the finite element method

3.1 Introduction

3.2 Weighted residual method

3.3 Finite element method

3.4 Finite element mesh

3.5 Trial basis (shape) functions

3.6 Galerkin finite element method

3.7 Mesh convergence

3.8 Finite element method with COMSOL Multiphysics

3.9 Summary

Chapter 4 Heat transfer in biological tissues

4.1 Introduction

4.2 Thermoregulation

4.2.1 Tissue metabolic activity

4.2.2 Blood perfusion

4.2.3 Mechanisms of heat exchange through the skin

4.3 Bioheat transfer

4.3.1 The Pennes model

4.3.2 The Wulff and Klinger models

4.3.3 Pennes vs Wulff vs Klinger models

4.3.4 The Chen and Holmes model

4.3.5 The Weinbaum-Jiji model

4.3.6 Porous medium bioheat transfer model

4.3.7 Initial-boundary conditions

4.3.8 Summary

4.4 Hyperthermia

4.4.1 Bioheat transfer analysis of hyperthermia

4.5 Thermal therapy

4.5.1 Whole-body and regional hyperthermia

4.5.2 Local hyperthermia

4.5.3 Summary

4.6 Thermal damage

4.6.1 Critical isotherm.

4.6.2 Cumulative equivalent minutes

4.6.3 The Arrhenius thermal damage model

4.6.4 Other thermal damage models

4.7 General summary

Chapter 5 Haemodynamics

5.1 Introduction

5.2 Arteries, veins, and capillaries

5.2.1 Arteries

5.2.2 Veins

5.2.3 Capillaries

5.3 Physical properties of blood

5.4 Haemodynamics of a single blood vessel

5.4.1 Poiseuille's law in blood flow analysis

5.4.2 Application of Poiseuille's law in atherosclerosis

5.4.3 Limitations of the Poiseuille's law in blood flow analysis

5.5 Computational fluid dynamics in blood flow analysis

5.5.1 Navier-Stokes equations

5.5.2 Boundary layer

5.5.3 Laminar vs turbulent flow

5.5.4 Applications of CFD in blood flow analysis

5.6 Blood flow in capillaries

5.6.1 Darcy's law

5.6.2 Permeability

5.6.3 Capillary as a porous medium

5.7 General summary

Chapter 6 Mass transport in biological tissues

6.1 Introduction

6.2 Fick's law of diffusion

6.3 Convection-diffusion equation

6.4 Transvascular fluid exchange

6.4.1 Starling law

6.4.2 Understanding oedema through Starling's law

6.5 Interstitial fluid flow

6.5.1 Tissue as a porous medium

6.5.2 Contributions from transvascular fluid exchange

6.5.3 Contribution from lymphatics

6.6 Drug delivery

6.6.1 Case study 6.2: drug delivery in solid tumours

6.7 Dual porosity model

6.7.1 Case study 6.3: comparison between single porosity and dual porosity models

6.7.2 Case study 6.4: saline-infused radiofrequency ablation

6.8 General summary

Chapter 7 Physiological modelling and data analytics

7.1 Fundamentals of physiological modelling

7.1.1 Data acquisition

7.1.2 Data processing

7.1.3 Model-based analysis

7.1.4 Data analytics

7.1.5 Data presentation.

7.2 Theories of model fitting and linear regression

Case study 7.1: Parameter identification (inverse simulation)

7.3 Data analytics and interpretation

7.3.1 Error analysis

7.3.2 Model results presentation

7.3.3 Statistical tests and data analysis

7.4 Summary

Chapter 8 Glucose-insulin system

8.1 Human endocrine system and the pancreas

8.2 Glucose level regulation and diabetes mellitus

8.2.1 Glucose level regulation

8.2.2 Diabetes mellitus

8.3 Model for human glucose-insulin interaction

8.3.1 Single-compartment model

8.3.2 Two-compartment model

8.3.3 Minimal model for glucose-insulin modelling

8.4 Application of glucose-insulin models in regulating glucose level

8.4.1 Diabetic patient glucose monitoring

8.4.2 Artificial pancreas

8.4.3 Intensive care hyperglycaemia patients

8.4.4 Sliding scale insulin infusion protocol

8.4.5 Model-based insulin protocol

8.5 Summary

Chapter 9 Respiratory system

9.1 Function of the human respiratory system

9.2 The mechanics of breathing

9.2.1 Breathing process and gas exchange

9.2.2 Respiratory diseases and failure

9.2.3 Mechanical ventilation

9.3 Respiratory system models

9.3.1 Single-compartment lung model

9.3.2 Other compartment lung models

9.3.3 Spontaneous breathing model

9.3.4 Isotropic expansion and recruitment model

9.3.5 Gas exchange model

9.4 Application of respiratory system models

9.4.1 Mechanical ventilation monitoring

9.4.2 Determining respiratory mechanics

9.4.3 Decision support system

9.5 Summary

Chapter 10 Cardiovascular system

10.1 The human cardiovascular system

10.1.1 Circulatory system

10.1.2 The anatomy and function of the heart

10.2 Cardiac cycle

10.2.1 Stages of a cardiac cycle

10.2.2 Key parameters of a cardiac cycle.

10.2.3 The cardiac cycle pressure-volume diagram

10.2.4 The cardiac output

10.3 Cardiovascular disease and circulatory shock

10.3.1 Cardiovascular disease

10.3.2 Circulatory shock

10.4 Cardiovascular system modelling

10.4.1 Fundamental concepts in modelling the cardiovascular system

10.4.2 Simple cardiovascular system models

10.4.3 Six-chamber cardiovascular system model

10.4.4 Electrocardiogram models

10.5 Application of the human cardiovascular system

10.5.1 Measurements for cardiovascular system

10.5.2 Simulation of cardiovascular system model

10.5.3 Six-chamber cardiovascular system model

10.5.4 Other applications of the cardiovascular system model

10.6 Summary

Chapter 11 Ethics and biosafety

11.1 Introduction

11.2 Human ethics

11.2.1 Clinical research

11.2.2 Ethics in clinical research (trials)

11.2.3 The seven requirements of ethical research

11.3 Biosafety

11.3.1 Biosafety in healthcare and medicine

11.3.2 Biosafety levels

11.4 Summary

Chapter

A.1 Fundamentals of heat transfer

A.2 Heat conduction

A.3 Heat convection

A.4 Heat radiation

A.5 Heat diffusion equation

Reference.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9780750346009

0750346000

OCLC:

1375639753