Imaging Modalities for Biological and Preclinical Research. Volume 2, Preclinical and Multimodality Imaging : A Compendium / edited by Andreas Walter, Julia Mannheim, Carmel J. Caruana.

Format:

Book

Contributor:

Walter, Andreas, editor.

Mannheim, Julia, editor.

Caruana, Carmel J., editor.

Series:

IPEM-IOP Series in Physics and Engineering in Medicine and Biology Series

Language:

English

Subjects (All):

Biomedical engineering.

Biomedical materials--Imaging compatibility.

Biomedical materials.

Imaging systems in biology.

Imaging systems in medicine.

Microscopy.

Physical Description:

1 online resource (398 pages)

Edition:

First edition.

Place of Publication:

Bristol, England : IOP Publishing, [2021]

Summary:

This compendium is designed to provide a comprehensive overview of currently available biological and preclinical imaging methods, including their benefits and limitations. Volume 2 covers in-vivo imaging techniques, correlative multimodal imaging and emerging imaging technologies.

Contents:

Intro

Preface

Acknowledgements

Editor biographies

Andreas Walter

Julia G Mannheim

Carmel J Caruana

List of contributors

Chapter

1 Introduction

2 Principles and setups

2.1 Physical principles

2.2 Typical setups and state-of-the-art

3 Biomedical relevance

3.1 Application range and relevance

3.2 Sample preparation

4 Parameters of image quality

4.1 Scattering

4.2 Spatial and temporal resolution

4.3 Setup: movement artefacts and awake imaging

5 Data processing

6 Conclusions

6.1 Strength and limitations

6.2 Future developments

References and further reading

4 Conclusions

4.1 Strength and limitations

4.2 Future developments

4.1 Excitation light source

4.2 Ultrasound detectors

4.3 Reconstruction methods

4.4 Detection geometry

5 Conclusions

5.1 Strength and limitations

5.2 Future developments

2.2 Typical setups

3.1 Application range

4.1 Spatial and temporal resolution

4.2 Tissue penetration depth

4.3 Bleed-through and crosstalk

5 Data processing and visualisation

6 Conclusion

6.1 Strengths and limitations

References and further reading.

Chapter II.4.b Bioluminescence

2.1 Chemical and physical principles

4.3 Background signal

Chapter II.4.c Cerenkov luminescence imaging

1 Introduction to Cerenkov luminescence

3.1 Preclinical application range and relevance

3.2 Clinical application range and relevance

3.3 CL activated agents

2.1 General presentation of an endoscopic exploration

2.2 Physical principles of an endomicroscope

2.3 Technical principles, typical setup and state-of-the-art of endomicroscopy

4.1 Label-free imaging of biological constituents

4.2 Movements and endomicroscopic examination

4.1 Resolution of ultrasound scanners

4.2 Artefacts in preclinical ultrasound imaging.

5 Data processing

Chapter II.7.b Functional magnetic resonance imaging

4.1 Signal-to-noise ratio

4.2 Motion and field distortion

4.3 Spatial/temporal resolution

4.4 fMRI statistical parameters

4.5 Physiological parameters

5.1 Masking

5.2 Global mean removal

Chapter II.7.c Hyperpolarised 13C magnetic resonance spectroscopic imaging

2.2 Radicals

2.3 Typical setups and state-of-the-art

3.2 Hyperpolarised 13C-labelled cell substrates

2.1 Particle properties

2.2 Physical principles

2.3 Instrumentation

3 Data processing

3.1 MPI problem formulation

3.2 System matrix reconstruction

3.3 X-space reconstruction.

4 Biomedical relevance

4.1 Diagnostic scenarios

4.2 Therapeutic scenarios

4.1 Radiation dose

4.2 Control of artefacts and image quality

2.1 Radiopharmaceuticals/radiotracers

2.3 PET detectors

2.4 Typical setups and state-of-the-art

2.5 Image reconstruction

3.2 Subject preparation

4.1 Chemical aspect influencing image quantification

4.2 Technological aspect influencing image quantification

4.3 Methodological aspect influencing image quantification

4.4 Biological aspect influencing image quantification

5.1 Image data analysis

5.2 Sample analysis

Chapter II.11 Single photon emission computed tomography

2.1 Principles of SPECT

4.1 Spatial resolution

4.2 Sensitivity

4.3 Noise

6.2 Future improvements.

References and further reading

2.1 Principle of CLEM

2.2 Setup of a CLEM experiment

3.1 The power of CLEM

3.2 CLEM workflows

3.3 A real CLEM example

4.1 Strengths and limitations

Chapter III.1.b Correlative atomic force microscopy

3 Conclusions

3.1 Strength and limitations

3.2 Future developments

4.1 Factors degrading image quality

4.2 PET/CT artefacts

4.3 PET calibration and quality control

4.4 CT calibration and quality control

4.5 PET/CT annual testing

Chapter III.2.b PET/SPECT/CT

Chapter III.2.c PET/MR

3.1 Applications in biological/preclinical research

3.2 Sample preparation and requirements.

4 Parameters of image quality.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references.

ISBN:

9780750342049

0750342048

OCLC:

1429723564