An introduction to physical oncology : how mechanistic mathematical modeling can improve cancer therapy outcomes / Vittorio Cristini, Eugene Koay, Zhihui Wang.

Format:

Book

Author/Creator:

Cristini, Vittorio, 1970, author.

Koay, Eugene, author.

Wang, Zhihui, 1976- author.

Series:

Chapman and Hall/CRC mathematical & computational biology series.

Chapman & Hall/CRC mathematical and computational biology

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Cancer--Mathematical models.

Physical Description:

1 online resource

Edition:

1st ed.

Place of Publication:

Boca Raton, FL : CRC Press, [2017]

Summary:

Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient's clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

Contents:

What should be modeled in cancer : milestones for physical models

Developing more successful cancer treatments with physical oncology

Mathematical pathology

Mathematical modeling of drug response

Prediction of chemotherapy outcome in patients

Clinical management of pancreatic cancer

Application of cancer physics in the clinic

Tumor morphological behavior and treatment outcome

Mechanistic model of tumor response to immunotherapy

Perspectives on physical oncology and future directions.

ISBN:

1-315-37449-8

1-315-35688-0

9781315374499

OCLC:

994873345