Processes and apparatus in chemical-pharmaceutical technology : the synthesis of medicinal products / by Ilia Manolov.

Format:

Book

Author/Creator:

Manolov, Ilia, author.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Physical Description:

1 online resource (359 pages)

Place of Publication:

Newcastle upon Tyne, England : Cambridge Scholars Publishing, [2022]

Summary:

The book combines theoretical knowledge with the industrial production of medicines. It describes the equipment of the industrial unit used for drug synthesis and production, as well as the chemical schemes and synthesis of important groups of medicines manifesting anticoagulant, antipyretic, antiseptic, pain-relief, anti-tumour, anti-tuberculosis and other properties. The book will be useful for chemistry students, medical students, teachers, toxicologists, pharmacologists and other specialists engaged in drug synthesis and production.

Contents:

Intro

Dedication

Table of Contents

Preface

Raw materials for the chemical-pharmaceutical industry

Waste in chemical-pharmaceutical production

Development of drug synthesis technology

What does a technology contain?

Pathways to original medicines

Good manufacturing practice

Good laboratory practice

Apparatus in the chemical-pharmaceutical industry

Synthetic methods and technologies for the production of antipyretics and analgesics of the aromatic group: aspirin,methylsalicylate, paracetamol

Synthetic methods and technologies for the production of analgesics and antipyretics of the heterocyclic group, pyrazolone derivatives: antipyrine, amidophen, analgin

Synthesis of 1-phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one (amidophen, pyramidone, amidopyrine)

Non-steroidal anti-inflammatory substances

Synthesis methods and technologies for the production of local anaesthetics

Synthesis and production of nootropic medicinal substances: Pyramem production technology

Calcium antagonists: Flunarizine

Synthesis and production of methylxanthine derivatives

Synthesis of nitro derivatives - antistenocardial agents

Technological features and approaches in beta-blocker production

Calcium antagonists - dihydropyridine derivatives: Synthesis of Nifedipine and Nitrendipine

Technological peculiarities and approaches in the production of ACE inhibitors

Synthesis and production of classical anti-tuberculosis agents

Hydrazides of pyridine carboxylic acids

Production of sulfonamides with thiazole heterocycle

Acylation of the amino group of Norsulfazol with phthalic acid

Sulfonamides with six-atoms heterocycles

Sulfonamide antidiabetics

Antidiabetic medicinal products

4-Quinolone derivatives

Imidazole derivatives - antifungal and antiprotozoal drugs.

Synthesis and production of barbiturates

Phenobarbital

Synthesis and production of certain benzodiazepines

Synthesis and production technology of some neuroleptics

Technology for the preparation of anticoagulants of the coumarin type

Alkylating substances with antitumor action

Production of water-soluble vitamins: Vitamin C production technology

Synthesis of isotopically labelled long-chain fatty acids for diagnosis of cardiovascular disease diagnostics

Synthesis of straight carbon chain ω- phenylalkanoic acids

Synthesis of long-chain branched-chain phenylalkanoic acids

Isotopic labelling of phenylalkanoic acids

Literary reference

Literature used

Literary sources.

Notes:

Includes bibliographical references (pages 331-343).

Description based on print version record.

Other Format:

Print version: Manolov, Ilia Processes and Apparatus in Chemical-Pharmaceutical Technology

ISBN:

9781527589674