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Natural Immunomodulators : Promising Therapy for Disease Management / edited by Vandana S. Nikam [and three others].
- Format:
- Book
- Author/Creator:
- Nikam, Vandana S, Author.
- Language:
- English
- Subjects (All):
- Biological response modifiers--Therapeutic use.
- Biological response modifiers.
- Immunotherapy.
- Physical Description:
- 1 online resource (441 pages)
- Edition:
- First edition.
- Place of Publication:
- Singapore : Bentham Science Publishers Pte. Ltd., 2023.
- Summary:
- Natural Immunomodulators: Promising Therapy for Disease Management discusses the use of natural immunomodulators as a promising therapy for managing various diseases. The book begins with an introduction to the immune system and the ways in which it can be modulated. This is followed by a discussion on the various diseases and disorders associated with the immune system, including autoimmune disorders, allergies, and immune deficiency conditions. The natural sources of immunomodulators, including plants, herbs, and other natural substances is also explained along with the importance of standardizing natural immunomodulator drugs, including the methods used to ensure their quality and consistency. The book also delves into the chemistry and analytical techniques used to study immunomodulators, clinical and pre-clinical bioassays. The next couple of chapters focus on the use of natural immunomodulators in cancer, the therapy of cancer and infectious diseases. Drug delivery and the strategy and regulatory perspective for natural immunomodulators. The final 2 chapters round up the contents with information about synthetic immunomodulators and the future perspective for the use of immunomodulators in disease management. Natural Immunomodulators: Promising Therapy for Disease Management is a comprehensive guide to the use of natural immunomodulators as a therapy for various diseases, and is a valuable resource for professionals and students interested in this topic. The book is aimed at health care professionals such as medical doctors, nurses, pharmacists, and life science and nutritionist professionals, as well as students.
- Contents:
- Cover
- Title
- Copyright
- End User License Agreement
- Contents
- Preface 1
- PREFACE 2
- Preface 2
- List of Contributors
- Introduction: Immune System &
- Modulation of Immune System
- Manali S. Dalvi1, Sanjay D. Sawant2 and Vandana S. Nikam1,*
- INTRODUCTION
- COMPONENTS OF THE IMMUNE SYSTEM
- Bone Marrow
- Thymus
- Lymph Node
- Spleen
- IMMUNE SYSTEM IS COMPOSED OF TWO MAIN COMPONENTS, NAMELY
- Innate Immunity
- Anti-microbial Substance
- Interferons
- Iron Binding Proteins
- Anti-Microbial Proteins (AMP)
- Complement
- Phagocytes
- Natural Killer Cells
- Mechanism of the Innate Response
- Cell Involve in Innate Immunity
- Granulocytes
- Macrophages and Mast Cells
- Dendritic Cells
- Adaptive Immunity
- Major Histocompatibility Complex Antigens
- Clonal Selection
- Cell-Mediated Response
- Activation of T Cells
- Humoral Response
- Activation of B Cells
- Immunological Memory
- ALLERGY AND HYPERSENSITIVITY REACTION
- Classification of Hypersensitivity Reactions
- Type I Hypersensitivity Reaction Fig.(10)
- Type II Hypersensitivity Reaction
- Type III Hypersensitivity Reaction
- Type IV Hypersensitivity Reaction
- IMMUNOMODULATION
- Microbiota and Prebiotic, Probiotics
- Micronutrients
- Natural Health Products
- Vaccines
- IMMUNOTHERAPY
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- Diseases and Disorders Associated with Immune System
- Pooja Shimpi1, Smita Pillewan2 and Vandana S. Nikam1,*
- CLASSIFICATION OF IMMUNE DISEASES AND DISORDERS
- BROAD CLASSIFICATION OF IMMUNE DISEASES AND DISORDERS
- Immunodeficiencies (IDs)
- Classification of Immune Diseases and Disorders Based on Inborn Errors of Immunity
- Phenocopies of Inborn Errors of Immunity
- X-linked Agammaglobulinemia
- Wiskott-Aldrich Syndrome (WAS).
- Ataxia Telangiectasia (A-T)
- DiGeorge Syndrome
- Secondary Immunodeficiency Disorders
- Allergic/ Hypersensitivity Reactions
- Allergic Rhinitis
- Atopic Eczema/ Atopic Dermatitis
- Urticaria
- Stevens-Johnson Syndrome
- Autoimmune Disorders
- CLASSIFICATION OF IMMUNE DISEASES BASED ON ORGAN SPECIFICITY
- ORGAN-SPECIFIC (LOCALIZED) DISEASES FIG. (3)
- Endocrinologic Diseases
- Hashimoto's (autoimmune) thyroiditis
- Neurological Disorders
- Introduction
- Alzheimer's Disease and Parkinson's Disease
- Multiple Sclerosis
- Auto-inflammatory Diseases/ Systemic Autoinflammatory Diseases (SAIDs)
- Classification Of Auto-Inflammatory Diseases
- Monogenic Autoinflammatory Diseases
- Polygenic Autoinflammatory Diseases
- ROLE OF THE IMMUNE SYSTEM IN CANCER
- IMMUNE CELLS AND CANCER PROGRESSION
- Natural Sources of Immunomodulators
- Vishal Bhange1, Monika Kale1, Ankita Dudhal1, Nikhil Putta2, Mukta Abhyankar2, Supriya Jagtap2 and Vandana S. Nikam1,*
- PLANTS AS SOURCE OF IMMUNOMODULATORS
- Glycosides
- Tannins
- Coumarins
- Anthocyanins
- Saponins
- Alkaloids
- Volatile Oils and Terpenoids
- MARINE-DERIVED IMMUNOMODULATORS
- Immunomodulatory Compounds from Marine Origin
- MICROBIOTA MODIFIERS
- Prebiotics
- Fructans (Fructo-oligosaccharide or FOS)
- β-Glucan
- Role of β-glucan Structure
- Probiotic
- Probiotic Augmentation Method in the Immune System
- Mechanism of Action of Probiotics
- VACCINES
- Jennerian Vaccines
- Live-attenuated Vaccines
- Inactivated Vaccines
- Toxoids
- Subunit, Recombinant, Polysaccharide, and Conjugate Vaccines
- Combination of Vaccine
- Messenger RNA (mRNA) Vaccines
- IMMUNOADJUVANTS
- MICRONUTRIENTS
- Vitamin A
- Vitamin C
- Vitamin D
- Vitamin B.
- Vitamin E
- TRACE ELEMENTS
- Essential Elements
- Zinc
- Selenium
- Copper
- Omega-3 Fatty Acid
- CONCLUDING REMARKS
- Standardization of Immunomodulator Natural Drugs
- Aishwarya R. Nale1 and Supriya G. Jagtap2,*
- NEED FOR DRUGS FROM PLANT ORIGINS OVER SYNTHETIC DRUGS
- STANDARDIZATION OF DRUGS FROM NATURAL ORIGINS
- Need for Standardization: Producers' and Consumers' Outlook
- Standardization of Natural Drugs Using Marker Compound Analysis
- Processes and Procedures for Standardisation and Quality Control of Natural Drugs are Described
- Authentication
- Foreign Matter
- Organic Evaluation
- Microscopy
- Volatile Matter
- Ash Value
- Extractive Values
- Chromatographic Profile of Marker Compound
- Pesticide Residues
- Determination of Heavy Metals
- Microbial Contamination
- Radioactive Contamination
- Current Natural Drug Standardization Regulations
- IMMUNOMODULATING PLANT DRUGS
- Importance of Natural Immunomodulators
- Ayurveda Concept
- PLANT TISSUE CULTURE
- Advantages of Plant Tissue Culture for Standardization of Phytoconstituents
- STANDARDIZATION OF NATURAL IMMUNOSTIMULANTS
- A. Tinospora Crispa
- Description
- Collection and Extraction
- Standardization
- Immunomodulatory Assays
- Results
- B. Mangifera Indica &
- Curcuma Domestica
- Phytochemical Screening
- C. Stereospermum Suaveolens
- Phytochemical Analysis
- Standardization.
- Immunomodulatory Assays
- D. Barleria Prionitis
- Collection and Storage
- Extraction
- STANDARDIZATION OF NATURAL IMMUNOSUPPRESSANTS
- A. Phyllanthus Amarus
- B. Zingiber Zerumbet
- Reversed-phase HPLC
- LC-MS/MS
- RP-HPLC
- C. Momordica Charantia
- Collection, Extraction and Standardization
- D. Terminalia Chebula
- Immunosuppressive Effect as an Anti-arthritic Treatment
- Immunosuppressive and Anti-arthritic Effects
- STANDARDIZATION OF IMMUNOMODULATING TISSUE CULTURED PLANTS
- Echinacea Angustifolia
- Cell Culture Formation &
- Helicteres Angustifolia
- Extraction of Callus Suspension Cultures
- FTIR Analysis
- Quantitative Analysis
- HPLC Analysis
- RESULTS
- Ftir Analysis
- Immunomodulators: Chemistry and Analytical Techniques
- Akalya Sendrayakannan1 and Prashant S. Kharkar1,*
- INTRODUCTION.
- IMMUNOMODULATORS
- Immunomodulators from Natural Sources
- PHYTOCHEMICALS AS IMMUNOMODULATORS
- Emodin
- Quercetin
- Resveratrol
- Genistein
- SEARCH FOR NEWER, SAFER IMMUNOMODULATORS
- ANALYTICAL TECHNIQUES FOR ISOLATION, PURIFICATION, QUANTIFICATION AND CHARACTERIZATION OF NATURAL IMMUNOMODULATORS
- Chromatography
- High-Performance Liquid Chromatography (HPLC)
- High-Performance Thin Layer Chromatography (HPTLC)
- Droplet Counter-Current Chromatography (DCCC)
- High-Speed Counter-Current Chromatography (HSCCC)
- High-Performance Capillary Electrophoresis (HPCE)
- Spectroscopy
- Ultraviolet/Visible (UV/Vis) Spectroscopy
- Fourier-Transform Infra-Red (FT-IR) Spectroscopy
- Mass Spectrometry (MS)
- Nuclear Magnetic Resonance (NMR) Spectroscopy
- BIOACTIVITY SCREENING METHODS FOR THE IMMUNOMODULATORS
- Bioassays and Other Methods for Immunomodulators in Preclinical and Clinical Setting
- Priyanka P. Nigade1, Pranjali S. Dhamane2 and Vandana S. Nikam1,*
- ASSOCIATION OF INNATE IMMUNITY AND ADAPTIVE IMMUNITY AND THEIR MEASUREMENTS
- Screening of Immunomodulators
- Animal Models used for Immunomodulatory Studies
- PRECLINICAL EVALUATION FOR IMMUNOMODULATORS
- CELL CULTURE
- IN VITRO METHODS FOR IMMUNOMODULATORS EVALUATION
- Inhibition of Histamine Release from Mast Cells [20 - 22]
- Mitogen-Induced Lymphocyte Proliferation /T Cell Proliferation Assay [17, 20, 23, 24]
- Inhibition of T Cell Proliferation [20]
- Phagocytosis Evaluation
- Chemiluminescence in Macrophages [20]
- Polymorphonuclear (PMN) Leucocyte's Function Test using Candida Albicans Spores [25, 26]
- PFC (Plaque Forming Cell) Assay [27]
- Inhibition of Dihydro-Orotate Dehydrogenase [20]
- MTT Assay &.
- Cyclic Voltammetry for Cell Viability and Proliferation.
- Notes:
- Includes bibliographical references.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- ISBN:
- 9789815123258
- 9815123254
- OCLC:
- 1382697006
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