Therapeutic use of plant secondary metabolites / Saheed Sabiu.

Format:

Book

Author/Creator:

Sabiu, Saheed, author.

Language:

English

Subjects (All):

Botany, Medical.

Pharmacology.

Plant metabolites.

Physical Description:

1 online resource (446 pages)

Edition:

First edition.

Place of Publication:

Singapore : Bentham Science Publishers, [2022]

Summary:

The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of diabetes, cancer, neurodegenerative disorders, and microbial infections. The 15 chapters in the book are written by eminent scholars, lecturers, and experts in indigenous knowledge systems (IKS), industrial and medicinal plants, phytotherapeutics, and phytoinformatics. Reports on health benefits of specific phytochemicals are also highlighted. In addition to basic concepts in medicinal chemistry and ethnopharmacology, the book covers the role of modern computer techniques in developing new pharmaceuticals from plant sources. Therapeutic Uses of Plant Secondary Metabolites is a timely and valuable reference for both undergraduate and postgraduate students in medicinal chemistry, as well as researchers and professionals in IKS, phytomedicine, ethnopharmacology, phytopharmacology, plant biotechnology, drug discovery and development, and phytotherapeutics.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

The Role of Plant Secondary Metabolites in Health Management

Taofik Olatunde Uthman1,*

1. INTRODUCTION

2. CLASSIFICATION OF PLANT SECONDARY METABOLITES

3. POLYPHENOLS - A MAJOR CLASS OF PLANT SECONDARY METABOLITES

3.1. Classes of Polyphenols

3.1.1. Phenolic Acids

3.1.2. Flavonoids

3.1.3. Lignans and Stilbenes

4. MEDICINAL PLANTS

5. PLANTS SECONDARY METABOLITES IN HEALTH MANAGEMENT

5.1. Alkaloids

5.2. Flavonoids

5.3. Terpenes

5.4. Saponins

CONCLUSION

CONSENT FOR PUBLICATION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Medicinal Plants and Drug Discovery

Emmanuel O. Ajani1,*

2. HISTORICAL USE OF PLANTS FOR PHARMACOLOGICAL PURPOSES

3. THE PROCESS AND TECHNIQUES OF DRUG DEVELOPMENT FROM PLANTS

Phase 1: Collection and Identification

Phase II: Isolation and Purification

Phase III: Synthesis of the Bioactive Compound

Phase IV: Clinical Trials

4. PLANTS BIOACTIVE COMPOUNDS AND THEIR APPLICATIONS IN SOME DISEASES

4.1. Plants Bioactive Compounds as Anticancer Agents

4.2. Plants Bioactive Compounds as Antimalarial Agents

4.3. Plants Bioactive Compounds as Antiviral Agents

5. PLANT-BASED DRUG AND THE CHALLENGE OF EMERGING INFECTIOUS DISEASES: COVID-19 EXPERIENCE

6. APPLICATION OF EMERGING TECHNOLOGIES IN PROMOTING DRUG DISCOVERY FROM PLANTS

(a). Proteomics, Genomics and Bioinformatics

(b). Combinatorial Chemistry

(c). High-Throughput Screening (HTS)

7. CHALLENGES TO DRUG DISCOVERY FROM PLANTS

8. DRUG DISCOVERY FROM PLANTS: THE CHALLENGE FOR AFRICA

9. FUTURE PROSPECT OF PLANT-BASED DRUGS

CONCLUDING REMARKS AND FUTURE PERSPECTIVE

ACKNOWLEDGEMENTS.

REFERENCES

Therapeutic Properties of Bioactive Secondary Metabolites in Essential Oil Crops

Fikisiwe C. Gebashe1, Adeyemi O. Aremu2,3 and Stephen O. Amoo1,2,4,*

2. SECONDARY METABOLITES AND THEIR ROLE IN PLANTS

3. MAJOR BIOACTIVE SECONDARY METABOLITES FROM ESSENTIAL OILS OF SELECTED MEDICINAL HERBS

4. PHARMACOLOGICAL PROPERTIES OF ESSENTIAL OILS MAJOR COMPOUNDS

4.1. Antimicrobial Activity

4.2. Anti-inflammatory

4.3. Antioxidants

4.4. Cytotoxicity

CONCLUDING REMARKS

Bioactive Compounds as Therapeutic Intervention in Cancer Therapy

Depika Dwarka1, Himansu Baijnath2 and John Jason Mellem1,*

2. CANCER AND APOPTOSIS

2.1. Global Prevalence of Cancer

2.2. General Features of Cancer

2.3. Pathophysiology of the Carcinogenic Process

2.4. Apoptosis: Hallmark of Cancer Development and Progression

2.5. Free Radicals and Anti-oxidants in Relation to Cancer Inflammation

3. MEDICINAL PLANTS: THEIR USE IN ANTI-CANCER TREATMENT

3.1. Plant Based Chemotherapeutics

3.1.1. Camptothecin

3.1.2. Paclitaxel and Docetaxel

3.1.3. Colchicine

3.1.4. Vinca Alkaloids

3.1.5. Homoharringtonine

3.1.6. Podophyllotoxin

3.2. Other Plant-based Compounds of Importance in Cancer Treatment

3.2.1. Phenolic Compounds

3.2.2. Alkaloids

3.2.3. Polysaccharides

3.2.4. Terpenoids

3.2.5. Quinones

Bioactive Compounds as Therapeutic Intervention in Mucocutaneous Cancers

Henry A. Adeola1,2,*, Rashmi Bhardwaj3, Aderonke F. Ajayi-Smith4, Afsareen Bano3, Tayo A. Adekiya5, Michael C. Ojo6, Raphael T. Aruleba7, Adeniyi C. Adeola8, Babatunji E. Oyinloye6,9 and Chinedu E. Udekwu10.

1. INTRODUCTION TO MUCOSAL AND SKIN CANCERS

1.1. Melanomas

1.2. Basal Cell Carcinoma

1.3. Squamous Cell Carcinoma

2. CONVENTIONAL MUCOCUTANEOUS CANCER THERAPY

2.1. Surgical Excision of Mucocutaneous Cancers

2.2. Non-surgical Treatment of Mucocutaneous Cancers

3. TARGETED MUCOCUTANEOUS CANCER THERAPIES

3.1. Purine/Pyrimidine Analogues

3.2. Photodynamic Therapy (using Antioxidants)

3.3. Bioactive Compound and Photodynamic Therapy-carotenoids, Flavonoids and Terpenoids

3.4. Emerging Targeted Molecular Therapies-Obstacles and Opportunities

4. BIOACTIVE COMPOUNDS AS POTENTIAL TARGETS FOR MUCOCUTANEOUS CANCERS

5. BIOACTIVE COMPOUNDS AND OMICS APPROACH IN MUCOCUTANEOUS CANCERS

6. BIOACTIVE COMPOUNDS AND IMPORTANCE IN THE TREATMENT OF MUCOCUTANEOUS CANCERS

6.1. Bioactive Compounds with Anti-skin Cancer Property

6.1.1. Curcumin

6.1.2. Myricetin

6.1.3. Tocotrienol

7. NOVEL APPLICATIONS OF BIOACTIVE FLAVONOID COMPOUNDS FOR MUCOCUTANEOUS CANCER MANAGEMENT

CONCLUSION AND FUTURE PERSPECTIVES

AUTHORS' CONTRIBUTIONS

Bioactive Compounds as Therapeutic Intervention in Bacterial Infections

Kazeem A. Alayande1,2,*, Abdulwakeel A. Ajao3 and Mariam O. Oyedeji-Amusa3

2. DIFFICULTIES IN THE TREATMENT OF BACTERIAL INFECTIONS

3. WHAT BIOACTIVE COMPOUNDS DO DIFFERENTLY

3.1. Efficiency of Bioactive Compounds against Bacterial Pathogens

3.2. Phenols and Phenolic Compounds

3.3. Alkaloids

3.4. Tannins

3.5. Terpenoids and Terpenes

3.6. Saponins

3.7. Flavonoids

3.8. Bioactive Peptides

The Use of Plant Secondary Metabolites in the Treatment of Bacterial Diseases.

Pillay Charlene1,*, Ramdhani Nishani2 and Singh Seema3

2. GROUPS OF SECONDARY METABOLITES WITH ANTIBACTERIAL ACTIVITIES

Terpenes

Phenolics

Flavonoids

Tannins

Coumarins

Quinones

Nitrogen Containing Compounds

Alkaloids

Sulphur Containing Compounds

Allicin

Ajoene

Sulforaphane

3. THE MODE OF ACTION OF SECONDARY METABOLITES ON MICROBIAL CELLS

Plant Secondary Metabolites in the Management of Degenerative Diseases

Judith N. Ohanaka1,*, Uwazie C. Kenneth2, Fatai O. Balogun3 and Saheed Sabiu3

2. SECONDARY METABOLITES

2.1. Major Classifications of Secondary Metabolites

2.1.1. Terpenoids

2.1.2. Phenolics

2.1.3. Alkaloids

3. SECONDARY METABOLITES IN THE MANAGEMENT OF BACTERIAL INFECTIONS

4. SECONDARY METABOLITES IN THE MANAGEMENT OF VIRAL INFECTIONS

5. SECONDARY METABOLITES IN THE MANAGEMENT OF MALARIA DISEASES

6. SECONDARY METABOLITES IN CANCER MANAGEMENT

7. SECONDARY METABOLITES IN DIABETES MELLITUS MANAGEMENT

Bioactive Compounds as Therapeutic Intervention in Neurodegenerative Diseases

N. Suleiman1,*, I. Bulama2 and L.S. Bilbis3

2. BIOACTIVE CHEMICALS

2.1. Role and Types of Bioactive Compounds

2.1.1. Phenolic Compounds

2.1.2. Omega-3 Fatty Acids and Fat-Soluble Vitamins

2.1.3. Isothiocyanates

2.1.4. Carotenoids

2.1.5. Mind Food

2.2. Application of Some of the Bioactive Compounds in the Treatment of Neurodegenerative Diseases

2.3. Constituents of Bioactive compounds

2.3.1. Flavonoids

2.3.2. Anthocyanins

2.3.3. Tannins

2.3.4. Betalins

2.3.5. Carotenoids

2.3.6. Plant Sterols.

2.3.7. Glucosinolates

3. NEURODEGENERATIVE DISEASES

3.1. Most Common Neurodegenerative Diseases

3.1.1. Alzheimer's disease (AD)

3.1.2. Parkinson disease (PD)

3.1.3. Huntington's Disease (HD)

3.1.4. Stroke

3.2. Pathophysiology of Neurodegenerative Diseases

Green Synthesis Application in Diabetes Therapy

Fatai O. Balogun1,* and Saheed Sabiu1

INTRODUCTION

Nano-synthesis Methods

Characterization of Nanoparticles

Green Synthesis of Nanoparticles

Interplay between Diabetes Mellitus, Medicinal Plants, and Nanotechnology

Safety Concerns

Mechanism of Action (MOA)

MATERIALS AND METHODOLOGY

DISCUSSION

An Update on Green Synthesis Application in Cancer Therapy

Karishma Singh1 and Saheed Sabiu1,*

2. GREEN SYNTHESIZED NANOPARTICLES IN CANCER THERAPY

2.1. Silver

2.2. Gold

2.3. Zinc Oxide

2.4. Mechanism of Action of AgNPs, AuNPs, and ZnONPs Against Cancer Cells

3. GREEN SYNTHESIS AND CHARACTERIZATION OF NANOPARTICLES

3.1. The Biological Approaches

3.2. Synthesis Using Microorganisms

3.2.1. Bacteria

3.2.2. Fungi

3.2.3. Cyanobacteria

3.2.4. Algae

3.3. Plant Extracts

3.4. Enzymes and Biomolecules

3.5. Characterization of Nanoparticles

4. Application of Green Synthesized Nanoparticles in Cancer Therapy

5. The Pros and Cons of Green Synthesized Nanoparticles in Cancer Therapy

CONCLUDING REMARKS AND PERSPECTIVES

Oxidative Stress Involvement in Antibacterial Therapy

Christiana E. Aruwa1 and Saheed Sabiu1,*

2. DISCUSSION.

2.1. Sources of Oxidative Stress.

Notes:

Includes bibliographical references.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9789815050622

9815050621

OCLC:

1348488682