Protein Tyrosine Phosphatase Interacting Protein 51 During Migration in Hacat Cells.

Format:

Book

Author/Creator:

Schubkegel, Eva.

Language:

English

Subjects (All):

Keratinocytes.

Cell migration.

Physical Description:

1 online resource (84 pages)

Edition:

1st ed.

Place of Publication:

Berlin : Lehmanns Fachbuchhandlung GmbH, Abt. Verlag, 2022.

Summary:

Survival comes and goes with migration! This thesis shows the importance of the Protein Tyrosine Phosphatase Interacting Protein 51 in migrating cells. Migrating cells are essential for wound healing - alias survival - or, on the other hand, are taking a responsible part of a carcinogen progress during metastatic invasion - alias death. Therefore, it is utmost of interest to discover more in detail the involved proteins and the protein-protein-interactions.

Contents:

1 Introduction

1.1 Migration

1.2 Protein tyrosine phosphatase interacting protein 51

1.3 Aim of the study

2 Material and methods

2.1 Methods

2.2 Compounds

2.3 Scratch protocol

2.4 Material

3 Results

3.1 The influence of the scratch on the PTPIP51 interactome in control cells

3.2 The influence of the scratch on the PTPIP51 interactome in EGF treated cells

3.2.1 PTPIP51/ β-actin interaction in migrating EGF-treated HaCaT cells

3.2.2 PTPIP51/ Rac-1 interaction in migrating EGF-treated HaCaT cells

3.2.3 PTPIP51/FAK interaction in migrating EGF-treated HaCaT cells

3.3 The PTPIP51 interactome in migrating insulin-treated HaCaT cells

3.3.1 PTPIP51/ β-actin interaction in migrating insulin-treated HaCaT cells

3.3.2 PTPIP51/ Rac-1 interaction in migrating insulin-treated HaCaT cells

3.3.3 PTPIP51/ FAK interaction in migrating insulin-treated HaCaT cells

3.4 The PTPIP51 interactome in migrating LDC-3-treated HaCaT cells

3.4.1 PTPIP51/β-actin interaction in migrating LDC-3-treated HaCaT cells with increasing concentrations

3.4.2 PTPIP51/Rac-1 interaction in migrating LDC-3-treated HaCaT cells with increasing concentrations

3.4.3 PTPIP51/FAK interaction in migrating LDC-3 treated HaCaT cells with increasing concentrations

4 Discussion

4.1 Wound healing and the PTPIP51 interactome

4.2 Framing the PTPIP51 in the migration process under EGF treatment

4.3 Framing the PTPIP51 in the migration process under insulin treatment

4.4 Framing PTPIP51 in the migration process under LDC-3 treatment

4.5 The PTPIP51 interactome within a migrating cell

5 Summary Generated by AI.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

9783965433748

3965433741

OCLC:

1492955257