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Functional analytical techniques in pharmaceutical chemistry / Malik Saadullah, editor.
- Format:
- Book
- Series:
- Analytical Chemistry and Microchemistry
- Language:
- English
- Subjects (All):
- Pharmaceutical chemistry.
- Physical Description:
- 1 online resource (312 pages)
- Edition:
- First edition.
- Place of Publication:
- New York : Nova Science Publishers, Inc., [2022]
- Summary:
- "Pharmaceutical Chemistry is a scientific discipline in the chemical and pharmaceutical field involved in the design and development of pharmaceutical drugs and their analytical techniques. Analytical chemistry is a branch of pharmaceutical chemistry that specializes in the analysis of various substances. It involves the separation, identification, and the quantification of matter by using classical and modern methods involving the use of scientific instruments. This book is an attempt to expose the analytical techniques used in pharmaceutical chemistry, so that one can possess command in analytical techniques"-- Provided by publisher.
- Contents:
- Intro
- Contents
- Preface
- Acknowledgment
- Chapter 1
- Background
- Abstract
- Introduction
- Importance of Analytical Chemistry
- Fundamental Research
- Product Development
- Product Quality Control
- Maintaining of Pollutants
- Assay
- Medical and Clinical Studies
- Analytical Issues and Their Solutions
- Selection of Method
- Sampling
- Preliminary Sample Treatment
- Separations
- Method Validation
- Assessment of Findings
- Types of Analytical Methods
- Accuracy
- Analyte
- Blank
- Calibration
- Concentration
- Constituent
- Detection Limit
- Determination
- Equivalent
- Estimation
- Interference
- Masking
- Matrix
- Method
- Variability
- Primary Standard
- Procedure
- Reagent
- Sample
- Sensitivity
- Standardization
- Standard
- Standard Addition
- Technique
- Validation of Methods
- Conclusion
- Conflict of Interest
- Consent For Publication
- References
- Chapter 2
- Separation Methods and Quality Control
- Types of Extraction
- Liquid-Liquid Extraction
- Types of Liquid-Liquid Extraction (LLE)
- Dispersive Liquid-Liquid Microextraction (DLLME)
- Direct Organic Extraction
- Extraction Without Chemical Change
- Ion Exchange Mechanism
- Ion Pair Extraction
- Advantages of LLE
- Disadvantages of LLE
- Solid-Liquid Extraction
- Types of Solid Phase Extraction (SPE)
- Normal Phase SPE
- A Solid Phase Extraction Involves Basic Five Steps
- Reverse Phase SPE
- Ion Exchange SPE
- Anion Exchange SPE
- Cation Exchange SPE
- Solid Phase Microextraction
- Supercritical Fluid Extraction
- Process of Super Critical Extraction
- Factors Affecting Extraction Efficiency
- Quality Control Separation
- Chromatographic Fingerprinting
- Thin Layer Chromatography
- Advantages of TLC
- Disadvantages of TLC.
- High-Performance Thin Layer Chromatography (HPTLC)
- Microemulsion-Thin Layer Chromatography (ME-TLC)
- Densitometric-Thin Layer Chromatography (Densitometric TLC)
- Two-Dimensional Thin Layer Chromatography
- Graft Thin Layer Chromatography
- HPLC: High Performance Liquid Chromatography
- Disadvantages of HPLC
- Ultra-High Performance Liquid Chromatography UHPLC
- Hydrophilic Interaction Liquid Chromatography
- Gas Chromatography
- Miniaturized Separation Techniques
- Separation Techniques Isocratic versus Gradient Elution
- Consent for Publication
- Chapter 3
- Physical Methods of Analysis
- Solubility Determination
- Basic Concepts of Solubility
- Classification of Solutions
- Mechanism of Solubility (Dispersibility)
- Factors Affecting the Solubility (Dispersibility)
- Solubility Test Methods
- Shake Flask Technique
- Miniaturized Shake Flask Method
- Small Scale Shake-Flask Method
- Equilibrium 96-Well Microtiter Plate Methods
- Column Elution Method
- Solubility Enhancement Techniques
- Applications
- Molecular Weight Determination
- Osmometric Method
- Membrane Osmometers
- Cryoscopic Method
- Ebullioscopic Method
- Mass Spectrometry
- Viscosity Determination
- Factors Affecting Viscosity
- Types of Viscometer
- Ostwald Viscometer
- Falling Ball Viscometer
- Cup-Bob Viscometer
- Cone and Plate Viscometer
- Surface Tension Determination
- Factors Affecting the Surface Tension
- Methods for Determining Surface Tension
- Static Surface Tension Measurement Methods for Liquids
- Dynamic Surface Tension Measurement Methods for Liquids
- Surface Tension Measurement Methods for Solids
- Standard Contact Angle Measurement Methods for Various Materials
- X-Ray Diffractometry.
- Principle
- Bragg's Law
- Thomson Scattering
- Application of X-Ray Diffraction
- X-Ray Fluorescence Analysis (XFA)
- Working
- Applications of X-Ray Fluorescence Analysis
- Polarimetry
- Features Affecting Optical Activity
- Important Tools CD and ORD
- Refractometry
- Principle
- Factors Affecting the Refractive Index
- Particle Size Analysis
- Methods Used for the Analysis of Particle Size
- Microscopy
- Sieving
- Sedimentation Methods
- Zone Sensing Method
- Light Scattering Method
- Chapter 4
- Classical Methods of Analysis
- Acid and Base
- pH
- Buffer Solutions
- pH Measurement Methods
- Application of Indicator for pH Measuring
- Flaws
- Method for Hydrogen-Electrode
- Quinhydron-Electrode Method
- Method of Antimony-Electrode
- Method of Glass-Electrode
- Semiconductor Sensor Methods
- Oxidation Reduction Reactions
- Titration
- Nonaqueous Acid-Base Titrations
- Chelatometry or Complexometric Titration
- Argentometric Titrations
- Mohr Method, Chromate Ion
- Volhard Method, Iron (III) Ion
- Fajans Method, Adsorption Indicator
- Redox Titrations
- Titration Involving Potassium Permanganate (KMnO4)
- Safety Precautions
- Reagents
- Iodine Redox Titrations
- Titrations Require Iodine
- Iodimetry
- Iodometry
- Ascorbic Acid Analysis by Iodimetry
- Hydrogen Peroxide Analysis by Iodometry
- Titration of Ceric Sulfate
- Scope of Application
- Gravimetric Methods
- Precipitation Gravimetry
- Electrogravimetry
- Miscellaneous Types of Analysis
- Recommended Procedure
- Fats and Fatty Oils Analysis
- Acid Value (AV)
- Saponification
- Procedure.
- Iodine Value (IV)
- Method I (Hanus Method)
- Method II
- KI Solution
- Hydroxyl Value
- Ester Value (EV)
- Acetyle Value
- Analysis of Alkaloids
- Classification Established upon the Biogenesis
- Protoalkaloids
- Pseudoalkaloids
- True Alkaloids
- Classification Established upon the Ring Structure
- Tropane Alkaloid
- Pyrrolizidine Alkaloids
- Piperidine Alkaloids
- Quinolines Alkaloid
- Isoquinoline Alkaloids
- Indole Alkaloids
- Steroidal Alkaloids
- Imidazole Alkaloid
- Purine Alkaloids
- Pyrrolidine Alkaloids
- Tests of Alkaloids
- General Precipitative Reagents
- Colour Tests
- Analysis of Volatile Oil
- Chapter 5
- Electrochemical Methods of Analysis
- Electrochemical Cell
- Notation to Describe the Electrochemical Cell
- Galvanic or Voltaic Cell
- Galvanic Cell Characterized by Following Features
- Electrolytic Cell or Electrolysis
- Electrolytic Cells Are Characterized by the Following Features
- Reversible Cell
- Standard Hydrogen Electrode (SHE)
- Standard Electrode Potential
- Ohmic Drop (IR)
- Electrochemical Cell Construction and Working
- Different Cell Design
- Surface Area
- Stirring
- Electrode
- Types of Electrochemical Methods
- Constant Current Electrolysis
- Factors Affecting the Deposition
- Constant Potential Electrolysis
- Application of Electrogravimetry
- Coulometry
- Principle and Theory
- Types of Coulometry
- Coulometry at Constant Potential
- Controlled-Current Coulometry
- Applications of CPC and CCC
- Coulometric Titration
- Conductometry
- Voltammetry
- Types of Voltammetry Methods
- Hydrodynamic Voltammetry
- Pulse Voltammetry
- Stripping Voltammetry.
- Cyclic Voltammetry
- Principle Methods Involved in Voltammetry
- Polarography
- Types of Polarography
- Apparatus and the Methods
- Electrodes
- Limitations of Polarography
- Advantages
- Amperometry
- Potentiometry
- Typical Arrangement for a Potentiometric Sensor
- Limitation
- Types of Working Electrodes Used in the Electrochemical Analysis (Carbon Nanocomposite-Based Electrodes)
- Mercury Capillary Electrodes
- Carbon Paste Electrodes (SPEs)
- Glassy Carbon Electrodes (GCEs)
- Carbon Ceramic Electrodes (CCEs)
- Graphite Rod or Pencil Graphite Electrode (GREs)
- Metallic Electrodes (MEs)
- Screen-Printed Electrode
- Transparent Conducting Electrodes
- Rotating Disk Electrode (RED)
- Rotating Ring-Disk Electrode (RRDEs)
- Acknowledgement
- Chapter 6
- Radiochemical Methods of Analysis
- What Is Radiochemistry?
- What Is Radiochemical Analysis?
- General Principle of Radiochemical Analysis
- Drawbacks of Radiochemical Analysis
- Selection of Radiochemical Analysis
- Types of Radiochemical Analysis
- Neutron Activation Analysis
- Principle of Neutron Activation Analysis
- Applications of Neutron Activation Analysis (NAA)
- Isotope Dilution Analysis
- Radioactive Isotopes Dilution or Direct Dilution of Isotope
- Inactive Isotopes Dilution or Reverse Dilution of Isotopes
- Inactive Isotopes of Multiple Dilution or Double Dilution of Isotope
- Application of Isotope Dilution Method
- Tracer Method
- Principle of the Tracer Method
- Applications of the Tracer Method
- Radioactive Decay
- Radioactive Decay Law
- Types of Radioactive Decay
- Alpha Decay
- Beta Decay
- Negative Beta Decay.
- Positive Beta Decay.
- Notes:
- Includes bibliographical references and index.
- Description based on publisher supplied metadata and other sources.
- Description based on print version record.
- Other Format:
- Print version: Saadullah, Malik Functional Analytical Techniques in Pharmaceutical Chemistry
- ISBN:
- 9798886972887
- OCLC:
- 1347028215
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