Properties and Uses of Oleanolic Acid / edited by Nidhi Gupta, Meenakshi Dhanawat.

Format:

Book

Contributor:

Gupta, Nidhi (Pharmacologist), editor.

Dhanawat, Meenakshi, editor.

Series:

Biochemistry research trends series.

Biochemistry Research Trends Series

Language:

English

Subjects (All):

Triterpenoid saponins--Therapeutic use.

Triterpenoid saponins.

Cancer--Treatment.

Cancer.

Physical Description:

1 online resource (172 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"Cancer is a leading cause of death worldwide. In 2018, 9.6 million deaths were attributed to cancer, and it is affecting around 18 million patients each year. Natural Products have been considered as the major source of lead compounds for cancer treatment. A large number of natural products have been reported by researchers all over the world and many of them are in clinical trials. In recent years, there has been a growing interest in pentacyclic triterpenoids such as Oleanolic acid, -Boswellic acid, Ursolic acid, Betulinic acid, Glycyrrhetinic Acid and Maslinic acid as potential anticancer agents reflected by the exponential increase in the number of scientific publications and patents published on these natural products all over the world. Moreover, some of these pentacyclic triterpenoids have already been marketed in some countries as therapeutic agents for the treatment of several disorders such as cancer, diabetes, inflammation, liver disorders, etc. Two major derivatives of oleanolic acid, CDDO and CDDO-Me have been entered into clinical trials against cancer. This book highlights the potential of oleanolic acid and its derivatives in the treatment of several human disorders. Initial chapters discuss the sources, extraction, biosynthesis and various reported biological activities of oleanolic acid while subsequent chapters describe the in vitro and in vivo applications of oleanolic acid and its different derivatives in several diseases such as bacterial infections, breast cancer, colon cancer and hepatic disorders. The last chapter of the book describes the nanoparticle mediated delivery of oleanolic acid in cancer"-- Provided by publisher.

Contents:

Oleanolic acid : sources, extraction, characterization and biosynthesis / Sarita Sharma, Nandini H.S., Deepak Kumar Jha and Nandini Bhardwaj

Pharmacological potential of natural biological product : "Oleanolic Acid" / Ranjan Kumar Singh, Rajshree Dahiya, Naidu Narapusetty, M. V. Jahansipriya, Chennu M. M. Prasada Rao, Tanniru Rajeswari, Narla Mahendra Kumar, and Komal Sharma

Oleanolic acid and its derivatives : therapeutic potential in bacterial infections / Rishabh Chalotra, Muhammed Amanat, Meenakshi Dhanawat and Randhir Singh

Oleanolic acid and its derivatives : therapeutic potential in breast cancer / Sonia Kamboj, Minky Mukhija, Jyoti, and Anurag Bhargava

Oleanolic acid and its derivatives : therapeutic potential to exhibit hepatoprotective effects / Jaya Rautela, Kiran Dhobhal, Poonam Joshi, Vikash Jakhmola and Itika Guleria

Oleanolic acid and its derivatives : therapeutic potential in colon cancer / Hitesch Kumar, S. M. Basavarajaiah, Bhawna Chopra, Manu Sharma and Nidhi Gupta

Nanoparticles-mediated delivery of oleanolic acid in cancer / Kumbham Soniya and Biswas Swati.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references and index.

ISBN:

9798891135734