Synthetic cannabinoids in drug discovery : design, synthesis and evaluation of modified coumarins as CB receptor ligands / Florian Mohr.

Format:

Book

Author/Creator:

Mohr, Florian, author.

Series:

Beiträge zur organischen Synthese

Language:

English

Subjects (All):

Cannabinoids--Therapeutic use.

Cannabinoids.

Physical Description:

1 online resource (ix, 344 pages).

Place of Publication:

Berlin : Logos Verlag Berlin, 2019.

Summary:

Long description: The endocannabinoid system represents a highly complex lipid-based (neuro-) transmitter system and can be found in nearly all animals. Since the discovery of the two main cannabinoid receptors CB1 and CB2 in the early '90, intensive research reviled a substantial influence of this system on many physiological and pathophysiological processes. Direct and selective targeting of the system bears a huge potential for the development of novel therapeutic approaches, especially for the treatment of chronical pain, inflammation or other neurological disorders. Therefore, the endocannabinoid system is a promising target in drug development. In the presented thesis, the design, syntheses and pharmacologic evaluation of substituted coumarins as potential new drug candidates as selective synthetic cannabinoids were investigated. In a combinatorial synthetic approach, several new libraries of new ligands were synthesised and subsequently pharmacological tested. Additionally, in a second project, novel reversible monoacylglycerol lipase (MAGL) inhibitors have been synthesized and pharmacologically evaluated. Thereby, several important structure-activity relationships for high potency or selectivity were found. Nearly all potencies of the developed inhibitors were determined in the nanomolar regions.

Notes:

PublicationDate: 20200526

Includes bibliographical references.

Description based on print version record.

ISBN:

3-8325-8707-1

9783832587079