Mitophagy and Its Role in Health and Disease / Shalini Mani, editors.

Format:

Book

Contributor:

Mani, Shalini, editor.

Series:

Cell biology research progress.

Cell Biology Research Progress Series

Language:

English

Subjects (All):

Cell physiology.

Cellular control mechanisms.

Cytology.

Mitochondrial pathology.

Physical Description:

1 online resource (317 pages)

Edition:

First edition.

Place of Publication:

New York : Nova Science Publishers, Inc., [2024]

Summary:

"Discover the fascinating world of mitophagy and its profound implications in aging, diseases, and therapeutic interventions. In this book a team of leading experts delves into the intricate mechanisms and far-reaching effects of mitophagy in a variety of medical conditions. The book begins with an insightful overview of mitophagy, laying the foundation for a comprehensive exploration of its role in aging cardiomyopathy, cardiovascular diseases, neurological disorders, and neurodegenerative diseases. Moving forward, the book addresses the growing interest in natural remedies. It investigates the role that herbs play in promoting mitophagy to cope with disorders. Readers will explore the therapeutic potential of herbs, and the effects of yoga, opening new avenues for treatment and management. Readers will gain a deep understanding of how this selective degradation and recycling process affects these medical conditions and how it can potentially be targeted for therapeutic interventions. With current understanding and future perspectives, readers will grasp the significance of mitophagy in various biological processes and the potential implications for enhancing cell function and overall well-being in older adults. "Mitophagy and its Role in Health and Disease" is a one-of-a-kind resource that brings together cutting-edge research, in-depth analysis, and future perspectives on mitophagy. This book holds tremendous value for researchers, medical professionals, and students seeking to expand their knowledge regarding the role of mitophagy in aging, disease processes, and therapeutic interventions"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Acknowledgments

Chapter 1

Overview of Mitophagy

Abstract

Introduction

Mitochondrial Quality Control

Mitophagy

Mechanism of Mitophagy

Regulators of Mitophagy

The Physiological and Pathophysiological Role of Mitophagy

Mitophagy in Cancer

Development and Ageing

Mitophagy in Neurodegenerative Diseases

Mitophagy in Diabetes/Obesity

Mitophagy in Liver Diseases

Mitophagy Targeting Drugs and Their Role in Therapeutics

Conclusion

References

Chapter 2

Aging Cardiomyopathy: The Role of Mitophagy

Mitochondrial Connectivites

Mitochondrial Fusion

Mitofusins-Mediated Mitochondrial Fusion

Optic Atrophy Factor 1 (Opa1) Mediated Mitochondrial Fusion

Mitochondrial Fission

Experimental Approaches for Assessing Mitophagy

Cardiac Aging and Mitophagy

Mitophagy Receptors

Mechanisms Mediating Mitophagy in the Heart

Parkin-Dependent Mitophagy

Role of Drp1 in Mitophagy in The Heart

Light Chain 3 (LC3) Mediated Mitophagy

Ubiquitin-Independent Mitophagy

Additional Parkin-Independent Mitophagy

Novel Regulatory Pathways

Other Mechanisms Mediating Mitophagy in the Heart

Manifestation of the Aging Heart

Chapter 3

Mitophagy in Cardiovascular Diseases

Atherosclerosis

Ischemic Heart Disease

Hypertension

Arrhythmia

Heart Failure

Cardiomyopathies

Chapter 4

Mitophagy in Neurological Disorders

The Role of Parkin/PINK1 Mediated Pathway in Neurological Discorderas

Oxidative Stress

Mitophagy Defects and Oxidative Stress in Various Neurological Disorders

Parkinson's Disease (PD)

Alzheimer's Disease (AD).

Amyotrophic Lateral Sclerosis (ALS)

Accumulation of Aggregated Misfolded Proteins

Impairment of Degradative Processes, Including Mitophagy, and Ubiquitin Proteasome System

Mitophagy and Neuroinflammation

Chapter 5

Mechanisms and Role of Mitophagy in Neurodegenerative Diseases

Signaling Pathways in Mitophagy Mechanism

Protein Pathways

PINK1/Parkin-Mediated Mitophagy

Nix/Bnip3-Mediated Mitophagy

FUNDC1-Mediated Mitophagy

p62/SQSTM1-Mediated Mitophagy

Other Proteins-Mediated Mitophagy

Lipid Pathways

Cardiolipid-Mediated Pathway

Cholesterol and Fatty Acids-Mediated Pathway

Mitochondrial Dynamics and Fusion

Inducers of Mitophagy

Mitophagy in Chronic Diseases of the Nervous System

Alzheimer's Disease (AD)

Dementia

Huntington's Disease (HD)

Amyotrophic Lateral Sclerosis (ALS)

Multiple Sclerosis (MS)

Mitophagy in Acute Disease of the Nervous System

Neonatal Hypoxic-Ischemic Encephalopathy (HIE)

Stroke

Epilepsy

Traumatic Brain Injury (TBI)

Future Perspective

Chapter 6

Mitophagy in Carcinogenesis and Cancer Therapy

Mitochondrial Dynamics

Mitochondrial Fission and Fusion

Molecular Mechanisms of Mitophagy Regulation

Molecular Mechanisms of Ubiquitin Type Mitophagy Pathway

The PINK1-Parkin Signaling Pathway in Mitophagy

Molecular Mechanisms of the Receptor-Mediated Pathway

BNIP3 and NIX/BNLP3L Signaling Cascade of Mitophagy

FUNDC1 Signaling Cascade in Mitophagy

Role of Mitophagy in Cancer

Mitophagy and Carcinogenesis

Mitophagy and Cancer Metastasis

Mitophagy and Drug Resistance

Mitophagy as a Target for Anticancer Therapeutics.

Promotion of Mitophagy Increases Cancer Apoptosis and Chemotherapy Sensitivity

Inhibition of Mitophagy Enhances Drug Sensitivity

Classical Inhibitors of Mitophagy

Novel Inhibitors of Mitophagy

Chapter 7

Mitophagy in Aging Muscle: Current Understanding and Future Perspectives

Mitochondrial Fission and Fusion: A Dynamic Role in Aging and a Potential Target for Age-Related Diseases

The Basics of Mitochondrial Structure

Mitochondrial Fusion and Fission Proteins and Processes

Fusion

Fission

Ubiquitin-Dependent Mitophagy Receptors

Ubiquitin-Independent Mitophagy Receptors

Lipid-Mediated Mitophagy

Mitophagy Inducers

Nutrient-Regulated Mitophagy

Mitochondrial DNA Damage

Mitophagy Pathways

Mitophagy in Mammals

Mitophagy in C. Elegans

Mitophagy and Aging

The Regulation of Mitophagy in Muscles

Mitochondrial Dynamics in Muscle-Implications for Mitophagy

Mitochondrial Dynamics in Aged Muscles

Mitophagy in Aging Skeletal Muscle

Mitophagy Targeting in Aged Muscles

Mitophagy Flux in Aged Muscles

Chapter 8

Epidemiology of Aging

Molecules or Signal Transduction Pathways in Aging

Molecules in Aging

MicroRNAs (miRNAs)

Telomere

p16, p53/p21

Signaling Pathway in Aging

Mammalian Target of Rapamycin (mTOR) Pathway

Nuclear Factor of Activated B-Cell (NF-κB) Signaling Pathway

Nuclear Factor-E2-Related Factor 2 (Nrf2) Signaling Pathway

Wnt/β-Catenin Signaling Pathway

Mitochondrial Basis of Aging

Somatic Mitochondrial DNA Mutations

ROS and Oxidative Stress

Mitophagy Process

Parkin Dependent

Parkin Independent

Ubiquitin Ligase Mediated Mitophagy.

Receptor-Mediated Mitophagy

Role of Mitophagy in Aging: Regulating Autophagy in Different Organ Systems

Heart

Brain

Musculoskeletal

Gastrointestinal

Lungs

Synthetic and Natural Compounds to Modulate Mitophagy during Aging

Chapter 9

Mitophagy and Age-Associated Diseases

Mitochondrial Theory of Aging

PINK1 and Parkin Regulated Mitophagy

Ubiquitin Independent Mitophagy

BNIP3 and NIX-Dependent Mitophagy

FUNDC-1 Mediated Mitophagy

Status of Mitophagy in Aging

Mitophagy and Neurodegenerative Diseases

Alzheimer's Disease

Parkinson's Disease

Huntington's Disease

Cardiovascular Diseases

Ischemia Strokes

Diabetic Cardiomyopathy

Targeting Mitophagy in Aging

Chapter 10

Triggering Mitophagy: A Promising Approach to Overcome Chemoresistance in Cancer Therapy

Cancer

Chemoresistance and Multiple-Drug Resistance

Mitochondria: Not Just the Powerhouse of the Cell

Mitochondrial Metabolism in Cancer-Resistant Cells

Regulation of Mitochondrial Dynamics

Mitophagy Manipulation/ Modulation as a Potential Cancer Therapy Target

Mitophagy Inhibition and Chemoresistance Case Studies

Mitophagy Activation in Certain Cases to Remove Chemoresistance

Chapter 11

A Workout for the Brain to Trigger Mitophagy

Yoga and Mitophagy

Neurodegenerative Diseases and Mitophagy

Amyotrophic Lateral Sclerosis (ALS).

The Effect of Yoga on the Progression of Neurodegenerative Diseases

Chapter 12

Role of Herbs on Mitophagy to Treat Neurodegenerative Disorders

Mechanisms of Autophagy

Mitophagy in Yeast

Parkin and PINK1 Dependent Pathway

Mitophagy in Red Blood Cells

Natural Products and Their Effect on Mitophagy for Neurodegenerative Diseases

Natural Extracts and Formulations Used to Improve Mitophagy for Neurological Disorders

Panaxnotoginseng

Ginkgo Biloba

Withaniasomnifera

Curcuma Longa

Artemisia Argyi Leaf Extract

Danggui-Shaoyao San

Tao hong Si wu Decoction

Polygala Saponins

Dendrobium nobileLindl. Alkaloids

Purified Fractions or Pure Molecules Isolated from Herbs

Astragaloside IV

Resveratrol

Silibinin

Eclalbasaponin l

Wogonin

Palmatine

Chapter 13

Therapeutic Tools for Mitophagy

Biomarkers Involved in Mitophagy

Mitophagy-Governed Pathology

Neurodegenerative Disorders

Metabolic Diseases and Diabetes

Muscle Dystrophy and Ageing

Myocardial Injury

Hepatic Disease

Therapeutic Intervention Modulating Mitophagy

Mitophagy Activators

PINK1 Activators

Parkin Activators

Mitophagy Inhibitors

USP30 Inhibitors

Peptide Inhibitors of Receptor-Mediated Mitophagy

Suppression of Mitochondrial Fragmentation

Chapter 14

Therapeutic Interventions in Mitophagy

Functional Association of Mitochondrial Dynamics and Mitophagy

Mitophagy and Human Diseases

Alzheimer's Disease and Therapeutic Interventions.

Parkinson's Disease and Therapeutic Interventions.

Notes:

Description based on publisher supplied metadata and other sources.

Description based on print version record.

Includes bibliographical references and index.

ISBN:

9798891136113