Magnetic Nanomaterials : Innovation for Cancer Theranostics.

Format:

Book

Author/Creator:

Mukherjee, Sudip.

Contributor:

Madamsetty, Vijay.

Pradhan, Lipi.

Yenurkar, Devyani.

Upadhyay, Anjali.

Series:

IPEM-IOP Series in Physics and Engineering in Medicine and Biology Series

Language:

English

Physical Description:

1 online resource (183 pages)

Edition:

1st ed.

Place of Publication:

Bristol : Institute of Physics Publishing, 2025.

Summary:

This book explores various methods of synthesis and characterization, as well as the diverse applications of MNPs, with a primary focus on cancer theranostics.

Contents:

Intro

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Magnetic nanoparticles (MNPs) have emerged as a dynamic and rapidly evolving field within nanomedicine that has revolutionized cancer theranostics. This book focuses on the recent advancements in MNP research, highlighting their methods of synthesis and their biomedical application including their role in targeted drug delivery, magnetic hyperthermia therapy, diagnosis, and imaging for cancer.&lt

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Acknowledgments

Author biographies

Sudip Mukherjee

Dr Vijay Sagar Madamsetty

Lipi Pradhan

Anjali Upadhyay

Devyani Yenurkar

Chapter Introduction to magnetic nanomaterials

1.1 History of metallic nanoparticles

1.2 Applications of magnetic nanoparticles in cancer theranostics

References

Chapter Synthesis of MNPs and their physicochemical characterization

2.1 Various methods for MNP synthesis

2.1.1 Physical synthesis methods

2.1.2 Chemical synthesis methods

2.1.3 Biological synthesis

2.2 Physicochemical characterization of MNPs

2.2.1 Size, shape, and surface morphology

2.2.2 Elemental mapping/composition

2.2.3 Bonding type and structure

2.2.4 Magnetism

2.3 Thermodynamic influences on MNP self-assembly and therapeutic uses

2.4 Use of MNPs in therapeutic applications

2.4.1 In cancer treatment

2.4.2 Use of MNPs in cancer diagnostics

2.4.3 Applications of MNPs in biomedical assays

2.5 Hybrid MNPs and overall industrial manufacture

2.5.1 Application of hybrid MNPs in cancer theranostics

Chapter Magnetic nanoparticles for cancer therapy

3.1 MNPs as drug delivery vehicles

3.2 MNPs as anticancer agents.

3.3 Immunomodulation and immunotherapy by MNPs

3.4 MNP-mediated photothermal therapy

3.5 MNPs in photodynamic therapy

3.6 Magnetic-hyperthermia-based therapy

3.7 MNPs in cancer theranostics (diagnosis and therapy)

3.8 Combination of therapies using MNPs

Chapter MNPs for cancer diagnosis and imaging

4.1 Overview of cancer diagnosis challenges

4.2 Role of magnetic nanoparticles as promising diagnostic tools

4.3 Magnetic resonance imaging

4.3.1 Mechanism of magnetic nanoparticles in enhancing MRI signals

4.3.2 Advantages of utilizing nanoparticles for tumor visualization

4.3.3 Examples of MRI with magnetic nanoparticles

4.4 Fluorescence imaging

4.4.1 Principles of fluorescence in cancer detection

4.4.2 Integration of magnetic nanoparticles for targeted fluorescence

4.4.3 Examples of fluorescence imaging with magnetic nanoparticles

4.5 Optical imaging techniques

4.5.1 Challenges and limitations in optical applications

4.5.2 Application of magnetic nanoparticles to improve optical contrast

4.5.3 Examples of the use of magnetic nanoparticles to improve optical contrast in cancer detection

4.6 Multimodal imaging methods

4.6.1 Definition and importance of multimodal imaging

4.6.2 Synergistic effects of combining MRI, fluorescence, and optical imaging

4.6.3 Examples of multimodal systems incorporating magnetic nanoparticles

4.7 Summary of the benefits of using magnetic nanoparticles in cancer diagnosis

4.7.1 Future perspectives and potential developments of magnetic nanoparticles in diagnosis and imaging

References and further reading

Chapter MNPs in clinical trials

5.1 Clinical trials of MNPs for imaging and diagnosis of cancer

5.1.1 Nano-SMART (NCT04789486), gadolinium-based nanoparticles for diagnosis of pancreatic and lung cancer.

5.1.2 Iron oxide nanoparticle magnetic needle (NCT01411904) for detection of leukemia

5.1.3 Ferumoxtran-10 enhanced MRI (NCT04261777, NCT02751606, NCT00107484) for prostate, rectal, and breast cancer

5.1.4 Magnetic nanoparticles for determination of blood tumor cells (NCT04290923)

5.1.5 Resovist (NCT00307866) as contrast enhancer in MRI for liver cancer

5.1.6 SPIO-enhanced MRI (NCT05359783) for sentinel node localization in breast cancer patients

5.2 Clinical trials of MNPs for therapeutic purposes in cancer

5.2.1 Magnetic particle thermoablation-retention in the prostate (NCT02033447)

5.2.2 Adjuvant therapy of glioblastoma multiforme using MNPs (NCT06271421)

5.2.3 MR-L-SPION (NCT04682847), SPIONs (superparamagnetic iron oxide nanoparticles) for hepatocellular carcinomas

5.2.4 Chemotherapy with superparamagnetic iron oxide nanoparticles (NCT04316091) for management of osteosarcoma

5.2.5 NANO-RAD for treatment of multiple brain metastases (NCT02820454 and NCT03818386)

5.2.6 NBTXR3 in addition to radiation therapy for cancer (NCT04484909, NCT01946867)

5.3 Patents filed on magnetic MNPs for advanced cancer theranostics

5.3.1 MNPs for treating cancer (WO2019072885A1)

5.3.2 Composite magnetic nanoparticle drug delivery system (US20120265001)

5.3.3 A kind of preparation method for dual-target magnetic nanoparticles for treating liver cancer (CN109701039A)

5.3.4 Preparation and application of an ultrahigh-field magnetic resonance contrast enhancer (CN112274657B)

5.3.5 Preparation and application of magnetic nanodrug carrier (CN112870387A)

5.3.6 Imaging device for in vivo nondestructive detection of skin cancer and application method thereof (CN118370528A)

5.3.7 Method for tumor detection and targeted hyperthermia (US20210300754A1)

References and further reading.

Chapter Magnetic nanoparticles: biodistribution, excretion, toxicity, and overall conclusions

6.1 Biodistribution and excretion of MNPs

6.2 Conclusions

References.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

0-7503-6335-5