HMGB1 : functions, inhibitors and clinical significance / Eylem Taskin, Celal Guven and Salih Tunc Kaya, editors.

Format:

Book

Contributor:

Guven, Celal, editor.

Kaya, Salih Tunç, editor.

Taskin, Eylem, editor.

Series:

Life Sciences Research and Development

Language:

English

Subjects (All):

Nervous system--Diseases.

Nervous system.

Chromatin.

Physical Description:

1 online resource (294 pages)

Edition:

1st ed.

Place of Publication:

New York, NY : Nova Science Publishers, Inc., [2023]

Summary:

"High mobility group box-1 (HMGB1) is one of the Damage-associated molecular patterns (DAMPs). HMGB1 plays plenty of role in both physiologic and pathophysiologic processes associated with its location, the receptor it binds to, and its redox form of its. Its functions are basically well known to have transcription factors, chemo-attractive effects, proinflammatory cytokine, neither chemokine nor cytokine effects, nor tissue repair function as well. This book provides an overview of the updated understanding of the dual role of HMGB1 in health and disease, such as cancer, myocardial ischemia/reperfusion injury, epilepsy, diabetes, multiple sclerosis, and neurodegenerative disease as well as hepatic steatosis and fatty liver disease been studied for years. That is why the modulation of HMGB1 might be a good candidate for the therapeutic of these diseases. Consequently, the present book comprises the role of HMGB1 in various pathologies and discusses its therapeutic potential in those pathologies"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Section I. HMGB1 and Cancer

Chapter 1

HMGB1-Targeting Herbal Medicinal Plant Extracts for the Phytotherapy of Cancer and Potential Management of COVID-19

Abstract

Introduction

Experiments

Results

Discussion

Apocynum cannabinum

Cinchona bark

Salvia miltiorrhiza

Reynoutria japonica

Artemisia capillaris

Persicaria hydropiper

Marrubium alysson

Ligustrum purpurascen, Ligstrum purpurascens, Rehmannia glutinosa

Lithospermum erythrorhizon

Mung bean (Vigna Radiata)

Salvia miltiorrhiza Bunge

Rhodiola rosea L.

Prunella vulgaris L.

Curcuma longa

Plumbago zeylanica

Aconitum carmichaelii Debeaux

Astragalus Mongholicus Bunge

Cucurbitaceae E.

Ecklonia cava

Angelica sinensis (Oliv.) Diels

Cyclopia intermedia E.Mey. (Honeybush)

Camellia sinensis L.

Glycyrrhiza glabra L. (Licorice)

Conclusion

References

Chapter 2

The Role of Ferroptotic Cell Death-Related HMGB1 in Inflammation Crosstalk with Cancer and Myocardial Ischemia/Reperfusion Injury

Inflammation

Cancer and Inflammation

Myocardial Ischemia/Reperfusion Injury and Inflammation

A Brief Overview of HMGB1

The Functional Role of HMGB1 in MIR Injury and Inflammation

The Functional Role of HMGB1 in Cancer and Inflammation

Is There a Link between Cancer and Myocardial Ischemia and Reperfusion Injury?

The New Cell Death Pathways: Ferroptosis

The Role of HMGB1 in Interaction of Cancer and MIR by Ferroptosis

Section II. HMGB1 and Metabolic Interactions

Chapter 3

The Role of HMGB1 in Adipocyte Dysfunction Linking Obesity and Type 2 Diabetes

Dysfunction of Adipocyte in Obesity and Type 2 Diabetes

HMGB1 Protein Structure and Function.

HMGB1 Receptor and Signaling Pathways in Adipose Tissue

RAGE

TLRs

Adipocyte Cell Death and HMGB1 Release

HMGB1 Linked Macrophage Associated Inflammation in Adipose Tissue

HMGB1 Secretion in Adipocyte

Chapter 4

The Roles of HMGB1 in Liver Injury

Liver Injury

HMGB1 and the Liver

HMBG1 and Inflammation

Drug Induced Liver Injury

ALD (Alcoholic Liver Disease) and HMGB1

Non-Alcoholic Fatty Liver Disease (NAFLD)

Viral Hepatitis and HBMG1

Sepsis

Acute Chronic Liver Failure (ACLF)

Hepatocellular Death and HMGB1

Section III. HMGB1 and Neurodegenerative Diseases

Chapter 5

The Role of HMGB-1 and Its Inhibitors in Brain Disorders

Introduction to High Mobility Group Box-1 Protein

HMGB-1 and Epilepsy

HMGB-1 and Headaches

HMGB-1 and Neuroimmunological Disorders

HMGB-1 and Neurodegenerative Diseases

HMGB-1 and Strokes

Chapter 6

The Roles of HMGB1 Post-Brain Injury: Implications for Injury and Repair

HMGB1 Role in Post-TBI Neuroinflammation

HMGB1 as a DAMP

HMGB1 Downstream Signalling and Subsequent Cytokine Release

HMGB1 Isoforms

HMGB1 in Grey Matter Injury and Repair

HMGB1 on Neuronal Loss and Glial Proliferation

HMGB1 Effect on Brain Oedema and Loss of BBB Function

HMGB1 Effects on Neurogenesis (in Enhancing Repair or Neuroprotection)

HMGB1 in White Matter Injury and Repair

HMGB1 on Axonal Demyelination/Axotomy and Oligodendrocyte Loss

HMGB1 and Oligodendrocytes and Post-Traumatic Oligodendrogenesis

HMGB1 Effect on Neurite Growth and the Neurovascular Unit

Summary

Key Potential Drugs

Inhibition of HMGB1 Release

Neutralising Antibodies and Small Molecule Inhibitors of HMGB1.

HMGB1 Receptor Antagonists

TLR4

Chapter 7

The Functional Role of HMGB1/TLR4/NF-κB Signalling Pathway in Multiple Sclerosis

High Mobility Group Box 1 (HMGB1): A Potential Therapeutical Target in MS Pathogenesis

Toll-Like Receptors (TLRs): It's Role in the Inflammatory Response

Nuclear Factor Kappa B (NF-κB): A View from Multiple Sclerosis Perspective

Current Treatment Strategies and Importance of This Pathway

Chapter 8

HMGB1 Related Pathways in Epilepsy

High Mobility Group Box 1 (HMGB1)

Inflammation and Neuroinflammation in the Nervous System

The Role of HMGB1 in Epilepsy

Alteration in HMGB1 in Epileptic Patients

Potential Role of HMGB1 in the Diagnosis and Treatment of Epilepsy

Index

About the Editors

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Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Taskin, Eylem HMGB1: Functions, Inhibitors and Clinical Significance

ISBN:

9798886974669