Green healer anti-diabetic nanomedicine for the management of diabetes mellitus / edited by Younis Ahmad Hajam.

Format:

Book

Contributor:

Hajam, Younis Ahmad, editor.

Series:

Endocrinology Research and Clinical Developments Series

Language:

English

Subjects (All):

Nanoparticles.

Nanomedicine.

Diabetes--Treatment.

Diabetes.

Physical Description:

1 online resource (298 pages)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, Inc., [2023]

Summary:

"The book entitled "Green Healer Anti-Diabetic Nanomedicine for the Management of Diabetes Mellitus" constitutes an extensive collection of articles on various aspects of diabetes and management such insects as over of diabetes and nanomedicines, role of melatonin in the regulation of diabetes, Nanomedicine as therapeutic Strategy for Diabetic Wound Healing, nano-phytomedicine and diabetes, Nano-Phytomedicine an emergent therapy for diabetes, role of nanomedicine in diabetes induced anti-inflammation, quercetin-loaded phyto-nanomedicines for management of cancer, encapsulated nanopolyphenol as a treatment of diabetes, antidiabetic Activity of Green Gold-Silver Nanocomposite and Nanomedicine and their Applications in Healthcare System: A Strategy to Control Metabolic Syndrome etc.The volume has all recent compilation and it will offer immense benefits to readers of all categories, viz. students and faculties for understanding the services of nanotechnology towards the treatment of diabetes. We congratulate all the contributors for putting together such exhaustive compilation of excellent chapters on "Green Healer Anti-Diabetic Nanomedicine for the Management of Diabetes Mellitus""-- Provided by publisher.

Contents:

Intro

Contents

Foreword

Preface

Acknowledgments

Chapter 1

Melatonin Loaded Nanomedicine for the Treatment of Diabetes

Abstract

1. Introduction

2. Brief Account on Diabetes Mellitus

3. Physiology and Pathophysiology of Melatonin

4. Melatonin as Nano-Medicine

5. History of Nano-Medicine

6. Different Nano-Careers for Melatonin Delivery

6.1. Lipid Based Nanocarriers

6.1.1. Liposomes NPs as Carriers of Melatonin

6.1.2. Lipid Formed Nanocarriers for Melatonin Transport

6.1.3. Lipids and Polymers Based Nanoparticles for Melatonin Administration

6.2. Niosomes for Melatonin Transport

6.3. Melatonin-Loaded Silica-Based NPs

6.4. Graphene and Melatonin Delivery

6.5. Nanofibers and Nanocapsule

6.6. Chitosan-Based NPs

6.7. Polymer Based Nanoparticles for Melatonin Transport

6.7.1. Polycaprolactone/Melatonin

6.7.2. Poly-Lactic Acid/Melatonin

6.7.3. Lactic-Co-Glycolic Acid Based Nanoparticles for Melatonin Transport

6.7.4. Polyethylene Glycol/Melatonin

6.7.5. Poly (Methacrylic Acid-Co-Methyl Methacrylate) Based Nanoparticles for Melatonin Transport

6.7.6. Nanogel (Polymeric Form) for Melatonin Transport

6.8. Metallic NPs and Melatonin Delivery

7. Cellular Mechanism of Melatonin Loaded Nano-Medicine against Different Ailments

8. Therapeutic Effects of Melatonin Based Nano-Medicine against Diabetes Mellitus

Conclusion and Future Perspectives

References

Chapter 2

Nanomedicine: A Therapeutic Strategy for Diabetic Wound Healing

2. Purpose of Chapter

3. Wound Infections and Pathobiology

4. Factors Affecting Wound Healing

4.1. Infection at Wound Site

4.2. Immune Condition of the Patient

4.3. Elderly Age

4.4. Disease Conditions

4.5. Reactive Oxygen Species (ROS)

4.6. Improper Diet.

5. Methods of Wound Healing

5.1. Haemostatic Phase

5.2. Inflammation Phase

5.3. Proliferative Phase

5.4. Remodelling Phase

6. Herbal Treatment for Diabetic Wound Healing

7. Nanoparticles in Wound Healing

7.1. Nanoparticle Therapeutic Drugs for Diabetic Wound Healing

8. Uses of Nanoparticles in the Medicine

8.1. Nanoparticles Efficacy

9. Therapeutic Applications for the Wound Healing

10. Nanoparticles for the Treatment of Infections

10.1. Nanoparticles Drug Delivery System (NDDS)

10.2. Lipid-Based Nanoparticles

10.3. Polymeric Nanoparticles (PNPs)

10.4. Nano Capsular or Nano-Spheres

10.5. Metal Nanoparticles

10.6. Toxicity of Nanoparticles

10.7. Chip Based Nanoparticles

11. Advantages of the Nanoparticles over the Traditional Medicine

12. Biomedical Applications of Nanoparticles

13. Future Strategies to Combat with Infections

Discussion

Conclusion

Chapter 3

Nano-Phytomedicines for the Prevention of Diabetes Mellitus: Pharmacological and Biopharmaceutical Perspectives

2. Types of Diabetes

2.1. Type-1-Diabetes

2.2. Type-2-Diabetes

2.3. Gestational Diabetes

3. Conventional Medication Used in Diabetes

3.1. Commonly Used Antidiabetic Drugs

3.2. Insulin: The Most Distinguished Anti-Diabetic Drug and Problem in Its Use

4. Nano‑Phytomedicine: An Alternative Approach for Combating Diabetes

4.1. Leonotisleonurus (L.)

4.2. Ficus religiosa L.

4.3. Plicosepalusacaciae (Zucc.)

4.4. Momordica charantia L.

4.5. Syzygiumcumini (L.) Skeels

4.6. Argyreia nervosa (Burm f.) Bojer

4.7. Cinnamonum spp.

4.8. Gymnemasylvestre (Retz.) R. Br. ex Sm

4.9. Marsilea quadrifolia L.

4.10. Cassia fistula L.

4.11. Zingiber officinale

Chapter 4.

The Emergence of Nano-Phytomedicines in Diabetes

2. Phytonano-Medicine Drug Formulations

2.1. Nano-Capsules

2.2. Nano-Tablets

2.3. Nanogels

2.4. Nanoemulsions

2.5. Nano Paste and Nano Pure (Nano-Air Purification)

3. Sources of Phytonanomedicines

3.1. Leaves

3.2. Flowers

3.3. Stem

3.4. Stem Bark

3.5. Seeds

3.6. Fruits

4. Synthesis of Phyto Metallic Nanoparticles (MNPs)

4.1. Types of Phytonanoparticles

4.1.1. Antidiabetic Potential of Silver Nanoparticles

4.1.2. Antidiabetic Potential of Gold Nanoparticles

4.1.3. Antidiabetic Potential of Zinc Nanoparticles

Chapter 5

Nanomedicines: Anti-Inflammatory Agents for the Treatment of Diabetes

2. Common Complications of Diabetes Mellitus

2.1. Cardiomyopathy

2.2. Peripheral Neuropathy

2.3. Nephropathy

2.4. Retinopathy

2.5. Foot Ulcer

2.6. Bone Disease

2.7. Miscellaneous Complications

3. Role of Inflammation in Diabetes

3.1. Tumor Necrosis Factor Alpha (TNF-α)

3.2. Interleukin-1 (IL-6)

3.3. Interleukin-18 (IL-18)

3.4. Interleukin-10 (IL-10)

3.5. Interleukin-1β (IL-1β)

3.6. Interleukin-11Ra (IL-1Ra)

3.7. Resistin

4. Anti-Inflammatory Agents for Diabetes

4.1. Metformin

4.2. Sulphonylureas

4.3. Thiazolidinediones (TZDs)

4.4. Sodium-Glucose Cotransporter 2 Inhibitors

4.5. Glucagon-Like Peptide 1 Receptor Agonists (GLP-1 Ras)

4.6. Dipeptidyl Peptidase-4 Inhibitors

4.7. Insulin

5. Nanomedicine as an Anti-Inflammatory Agent in Diabetic Management

6. Administration of Nanoparticles Based Anti-Diabetic Drug

6.1. Natural Polymeric Nanoparticles

6.1.1. Chitosan-Insulin Nanoparticles

6.1.2. Alginate-Based Nanoparticles

6.1.3. Dextran-Based Nanoparticles.

6.2. Synthetic Polymeric Nanoparticles

6.2.1. Poly (Lactic-Co-Glycolic Acid)-Induced Nanoparticles

6.2.2. Poly (Lactic Acid) (PLA)-Based Nanoparticles

6.2.3. Niosomes

6.2.4. Poly(Amidoamine)-Induced Dendrimers

6.2.5. Polymeric Micelles

6.2.6. Inorganic Nanoparticles

6.3. Lipid-Based Nanoparticles

6.3.1. Solid Lipid Nanoparticles (SLNs)

6.3.2. Nanostructured Lipid Carriers (NLCs)

6.3.3. Liposomes

6.3.3.1. Nanoemulsions

Chapter 6

Quercetin-Loaded Phyto-Nanomedicines for the Management of Cancer

2. Sources of Quercetin

3. Medicinal Benefits of Quercetin

3.1. Asthma, Allergies, Hives and Hay Fever

3.2. Antibacterial Activities

3.3. Cancers

3.4. Diabetic Complications

3.5. Neurodegenerative Disorders

4. Cancer

4.1. Quercetin's Anticancer Properties

5. Conventional Therapies to Treat Cancer

6. Limitations of Conventional Therapeutics

7. Nanotechnologies for Targeted Drug Delivery for Cancer

7.1. Active Targeting

7.2. Passive Targeting

7.3. Nanomedicine and Phyto-Nanomedicine

8. Advantages of Phyto-Nanomedicine

Chapter 7

Nanopolyphenols: The Perspective of Their Encapsulation and Anti-Diabetic Effects

1.1. Classification of Polyphenols

1.2. Need of Nanoencapsulation

1.3. Nanoencapsulation Techniques for Polyphenols

2. Physical Methods

2.1. Encapsulation by Spray-Drying

2.2. Spray-Cooling/Spray-Chilling

2.3. Freeze-Drying

2.4. Fluid Bed Drying

2.5. Extrusion and Spinning Disc

3. Chemical Methods

3.1. In Situ Polymerization

3.2. Coacervation

3.3. Liposomes

3.4. Yeast Encapsulation

4. Nanopolyphenols and Anti-Diabetic Effect

5. Plant-Derived Polyphenols as Anti-Diabetic Agents.

6. Nanopolyphenols as Anti-Diabetic Agent

6.1. Resveratrol

6.2. Glycyrrhizin

6.3. α-Eleostearic Acid

6.4. Naringenin

6.5. Gallic Acid

6.6. Gymnemic Acid

6.7. Pelargonidin

6.8. Ferulic Acid

6.9. Baicalin

6.10. Catechins

6.11. Thymoquinone

7. Other Polyphenols Based Anti-Diabetic Nanoformulations

Chapter 8

The Antidiabetic Activity of Green Gold-Silver Nanocomposites

2. Nanomaterials General Introduction and Historical Background

3. Contemporary Era of Nanotechnology

3.1. Methods for the Formulation of Nanocomposites

3.2. Formation of Metal Based Nanocomposites

4. Photochemical Based Synthesis of Nanocomposites

4.1. In-vitro and In-vivo Assay for Estimation of Anti-Diabetic Activity

4.1.1. Silver as an Anti-Diabetic Agent

4.1.2. Gold as an Anti-Diabetic Agent

5. Gold and Silver as Nanoformulations in Drug Delivery Systems as Advance Treatment of Diabetes Mellitus

6. Present Scenario and Future Perspective

Chapter 9

Nanomedicine in Diabetes: An Overview

2. Classification of Diabetes

2.1. Type I Diabetes

2.2. Type II Diabetes

3. Nanomedicine in Diabetes

4. Oral Insulin Delivery

5. Possible Mechanisms of Nanocarriers

5.1. Inhalable Nanoparticles

5.2. Microphysiometer

5.3. Artificial Pancreas

5.4. Artificial Pancreas Device System

5.4. Closed-loop' System

6. Changes in Beta Cell Mass and Characterization of Immune Cell Activity

7. Quantum Dots (QDs) (Liu et al., 2019)

8. Metformin Phenomenon

9. Insulin Based Nanogel - Smart Drug

Chapter 10

Exploring the Potential of Nanomedicine in Managing Metabolic Syndrome: Innovations in Healthcare

Abstract.

1. Introduction.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Hajam, Younis Ahmad Green Healer Anti-Diabetic Nanomedicine for the Management of Diabetes Mellitus

ISBN:

9798886978513

OCLC:

1381094656