Novel Drug Delivery Systems (Part 1).

Format:

Book

Author/Creator:

Mundada, Atish S.

Contributor:

Choudhari, Alap.

Language:

English

Physical Description:

1 online resource (271 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2024.

Summary:

Novel Drug Delivery Systems - Part 1 provides a comprehensive exploration of controlled drug delivery systems (NDDS) and their impact on patient outcomes and therapeutic effectiveness. Covering key topics like the principles of controlled-release dosage forms, the role of polymers, and innovative techniques like microencapsulation and mucoadhesive systems, this book bridges foundational concepts with cutting-edge advancements. It also addresses specialized systems like gastroretentive, transdermal, and ocular drug delivery methods. Ideal for pharmaceutical professionals, students, and researchers, this book serves as a critical resource for understanding and developing advanced drug delivery technologies.Key Features: - Comprehensive introduction to controlled drug delivery concepts - In-depth analysis of pharmacokinetics and polymers in NDDS - Exploration of microencapsulation and mucoadhesive systems - Insights into gastroretentive and transdermal drug delivery - Overview of nanotechnology and implantable devices in drug delivery - Coverage of the latest developments in injectables and ocular systems Readership: University students, researchers, pharmaceutical professionals, and general readers interested in advanced drug delivery systems.

Contents:

Intro

Title

Copyright

End User License Agreement

Contents

Foreword I

Foreword II

Preface

Dedication

List of Contributors

Controlled Drug Delivery Systems: Concepts and Rationale

Vipul D. Prajapati1,*, Princy Shrivastav2 and Kavita Suthar3

INTRODUCTION

Historical Overview

Rationale Behind CDDS

Classification of Controlled Release Drug Delivery Systems (CRDDS)

Based on Route of Administration

Based on Release Mechanism

Based on Design

Based on Matrix Type

Based on Stimulus Responsive Systems

DESIGN AND FORMULATION OF CDDS

Selection of Drug Candidates

Physicochemical Properties

Therapeutic Response

Pharmacokinetics

Pharmacodynamics

Safety and Tolerability

Patient Population

Regulatory Considerations

Polymer Selection and Drug-Polymer Compatibility

Biocompatibility

Degradability

Drug Loading and Release

Mechanical Properties

Drug Stability

Drug Solubility

Manufacturability

Manufacturing Techniques

PRINCIPLE OF CONTROLLED DRUG RELEASE

Mechanisms of Drug Release

Diffusion-based Release

Erosion-based Release

Osmosis-based Release

Mathematical Modelling of Drug Release

THERAPEUTIC APPLICATIONS OF CONTROLLED DRUG DELIVERY

Chronic Pain Management

Cancer Treatment

Diabetes Management

Other Therapeutic Areas

FUTURE TRENDS AND EMERGING TECHNOLOGIES

Nanotechnology in Drug Delivery

Personalized Medicine and Drug Delivery

Advancements in Drug Delivery Devices

Microneedles for Drug Delivery

CHALLENGES WHILE DEVELOPING CDDS

CONCLUSION

REFERENCES

Pharmacokinetic Considerations for Controlled-release Dosage Forms

Deepak S. Khobragade1,*, Surendra S. Agrawal1 and Mrunali S. Potbhare2

EXAMPLES OF CDDS

Transdermal Patches.

Microspheres and Nanoparticles

Implants

Osmotic Pumps

ADVANTAGES OF CONTROLLED DRUG DELIVERY SYSTEMS

Enhanced Therapeutic Efficacy

Minimized Systemic Side Effects

Increased Drug Bioavailability

Improved Patient Compliance

Reduced Drug Resistance

Personalized Medicine

Combination Therapy Optimization

Prolonged Drug Release

ROUTES OF ADMINISTRATION FOR CDDS

Oral Route

Transdermal Route

Intravenous (IV) Route

Intramuscular (IM) and Subcutaneous (SC) Routes

Implants and Depots

DESIRED BIOPHARMACEUTICAL CHARACTERISTICS OF DRUG TO QUALIFY FOR CDDS

Molecular Weight or Size

Solubility

Apparent partition coefficient (APC)

Low Toxicity and Side Effects

Therapeutic Index

Sufficient Half-Life

General absorption mechanism

Basic Pharmacokinetic Parameters

Biological Half-life (t½)

Minimum Effective Concentration (MEC)

Dose Size and Extent Of Duration

Total Clearance (CL)

The Terminal Disposition Rate Constant (Ke or λz)

Apparent Volume of Distribution (Vz)

Absolute Bioavailability (F)

Intrinsic Absorption Rate Constant (Ka)

Therapeutic concentration (Css)

Drug Absorption

Factors Affecting Absorption

Permeability Through Membranes

Solubility of Drug

Drug Ionization

Site Specific Conditions

Hepatic Metabolism

Interaction with Transporters

Interactions Between Food and Drug

Size of Particle in Formulation

Enzyme Activity

Rapid Onset of Action

Short Duration of Action

Fluctuating Drug Levels

Delay in Action Onset

Long Action Duration

Steady-state Drug Levels

Reduced Peak Concentrations

Drug Distribution

Tissue Penetration

Rapid Equilibration

Potential for Elevated Peak Concentrations

Short Duration of High Concentrations

Prolonged Exposure

Gradual Equilibration

Reduced Peak Concentrations.

Selective Targeting

Drug Efficacy

Safety

Dosage Regimen

Combination Therapy

Disease Characteristics

Drug Metabolism

Phase I Reactions

Phase II Reactions

Bioavailability

Prodrugs

Drug Elimination

Half-Life

Drug-Drug Interactions

Toxicity and Adverse Effects

Cytochrome P450 (CYP) Enzymes

Uridine Diphosphate-glucuronosyltransferases, or UGTs

Sulfotransferases (SULTs)

Flavin-Containing Monooxygenases (FMOs)

Renal Excretion

Hepatic Clearance

Other Clearance Mechanisms

Dosing Frequency

Steady-State Concentrations

Withdrawal

Dose Adjustments

Minimizing Fluctuations

Duration of Action

INFLUENCE OF ENZYMES ON PHARMACOKINETICS OF CDDS

Bioavailability Modification

Impact on Pharmacokinetics

Prodrug Activation

BIOAVAILABILITY OF CONTROLLED DRUG DELIVERY SYSTEM

Methods for Determining Bioavailability in CDDS

Pharmacokinetic Studies

Relative Bioavailability Studies

Steady-State Analysis

Bioequivalence Studies

Imaging Techniques

CHALLENGES AND CONSIDERATIONS IN THE BIOAVAILABILITY ASSESSMENT OF CDDS

Release Mechanism

Targeted Delivery

Variability

Sample Collection

IMPACT OF DRUG-DRUG INTERACTIONS ON PHARMACOKINETICS OF CDDS

Absorption Interactions

pH-Dependent Drug Delivery Systems and Acid-Suppressing Medications

Interactions Affecting Gastric Emptying Time

Complexation or Chelation Interactions

Alterations in Intestinal Permeability

Distribution Interactions

Protein Binding Interactions

Drug-Drug Interactions Affecting Tissue Penetration

pH-dependent Tissue Accumulation

Efflux Transporter Interactions

Changes in Blood Flow

Metabolism Interactions

Cytochrome P450 (CYP) Enzyme Interactions

Prodrug Activation.

Herb-Drug Interactions

Genetic Variations in Metabolizing Enzymes

Competition for Metabolic Pathways

Elimination Interactions

Renal Clearance Interactions

Hepatic Clearance Interactions

Gastrointestinal Interactions

Changes in pH and Drug Elimination

Drug-Drug Interactions Affecting Elimination

PHARMACOKINETICS OF NANO-BASED DRUG DELIVERY SYSTEMS

Absorption

Distribution

Metabolism

Excretion

PHARMACOKINETICS OF MICRONEEDLE

PHARMACOKINETIC MODELING OF CDDS

Compartmental Models

Non-Compartmental Models

Physiologically Based Pharmacokinetic (PBPK) Models

Monte Carlo Simulation

STEPS IN PHARMACOKINETIC MODELING FOR CDDS

Formulation Characterization

Input Data Collection

Model Selection and Development

Parameter Estimation

Model Validation and Prediction

STATISTICAL METHODS FOR DETERMINING PHARMACOKINETIC PARAMETERS

Exploratory Data Analysis Methods

Multivariate Approach (MANOVA)

Model Dependent Methods

Linear or First-order Regression Model

Nonlinear Regression Models

Quadratic Model or Second-order Regression Model

CONSTRAINTS ASSOCIATED WITH EXCLUSIVELY EMPLOYING PHARMACOKINETICS FOR THE DEVELOPMENT OF CONTROLLED-RELEASE DELIVERY SYSTEMS

Polymers: Backbone of Controlled Drug Delivery

Shweta H. Shahare1,*, Hitesh V. Shahare2, Nayana S. Baste2 and Atish S. Mundada2

TYPES OF POLYMERS

Classifications Based on Source of Origin

Natural Polymers

Semi-synthetic Polymers

Synthetic Fibres

Classifications Based on the Structure

Linear Polymers

Branching Polymers

Network or Cross-Linked Polymers

Classifications Based on Polymerization Process

Addition Polymers

Condensation Polymers

Classifications Based on Molecular Forces

Elastomer

Fibers

Thermoplastic Polymers.

Thermosetting Polymers

Classifications Based on the Homogeneity of Polymers

Classifications Based on Development Polymerization

Chain Expansion Polymerization

Step Growth Polymerization

Classification Based on Biostability

Biodegradable

Non-biodegradable

PROPERTIES OF POLYMERS

Chemical Properties

Thermal Properties

Viscoelastic Properties

Drug Release Mechanism from Polymer

Diffusion

Degradation

Swelling

Advantages of Polymers

CONTROLLED DRUG DELIVERY SYSTEM WITH POLYMERS

Protein-Based Polymers

Carbohydrate-Based Polymers

Synthetic Polymers

Polyhydroxy Butyrate

Polylactic Acid

Poly(e-Caprolactone)

Polyglutamic Acid

Polyamide

Poly (2-Hydroxyethyl Methacrylate)

Poly (Vinyl Alcohol)

Poly (N-Vinyl Pyrrolidone)

Poly (methylmethacrylate)

Poly (Acrylic Acid)

Poly (Ethylene Glycol)

Polyanhydrides

Diblock Copolymer

Triblock Copolymer

RECENT ADVANCES IN POLYMERIC DRUG DELIVERY SYSTEMS

Enteract Hpmcas Polymers

AFFINISOL Solubility Enhancing Polymers

Amberlite and Duolite Ion Exchange Resins

Ethocel

Polyox Water-soluble Resins

POLYMERIC MICRONEEDLE-BASED DRUG DELIVERY SYSTEM

Design Strategies of Long-acting Polymeric Microneedles

FACTORS AFFECTING BIODEGRADATION OF POLYMERS

Chemical Structure

Chemical Composition

Repeat Unit Distribution

Presence of Ionic Groups

Unexpected Units or Chain Defects

Configuration Structure

Molecular Weight

Molecular-Weight Distribution

Morphology

Low-Molecular-Weight Compounds

Processing Conditions

Annealing

Sterilization Process

Storage History

Shape of the Polymer

Site of Implantation

Adsorbed and Absorbed Compounds (Water, Lipids, Ions, etc.)

Physicochemical Factors (Ion Exchange, Ionic Strength, pH).

POLYMERS FOR RESPONSE-BASED RELEASE.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Mundada, Atish S. Novel Drug Delivery Systems (Part 1)

ISBN:

9789815274165

OCLC:

1481988797