Pyrimidines and their importance / edited by Roger G. Ward.

Format:

Book

Contributor:

Ward, Roger G. (Editor), editor.

Series:

Chemistry Research and Applications

Language:

English

Subjects (All):

Pyrimidines.

Physical Description:

1 online resource (170 pages)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, [2023]

Summary:

"This book contains four selected chapters on pyrimidines and their importance. The first chapter examines the synthesis, physico-chemical properties, and anti-fungal activity of new hybrids of thiazolo[4,5-D] pyrimidines with (1H-1,2, 4) triazole. The second chapter reviews pyrimidine ring containing natural products and their biological importance. The third chapter examines the regulation of the pyrimidine biosynthetic pathway in the bacterium Pseudomonas chlororaphis. The fourth and final chapter looks at pyrimidines as potential corrosion inhibitors"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

Synthesis, Physico-Chemical Properties and Antifungal Activity of New Hybrids of Thiazolo[4,5-D]Pyrimidines with (1h-1,2,4)Triazole

Abstract

Introduction

Experimental Section

General

Synthesis

General Procedure for Compounds of Group 1

General Procedure for Compounds of Group 2

Biological Study

Differential Scanning Calorimetry (DSC)

Powder X-Ray Diffraction (PXRD)

Kinetic Solubility Experiment

Equilibrium Solubility

Thermodynamic Models

Van't Hoff Equation

Modified Apelblat Equation

Model Accuracy

Thermodynamic Framework of Dissolution

Partition Experiment

Results and Discussion

Chemistry

Antifungal Аctivity

Solid State Characterization

Study of Dissolution and Transfer Processes of the Hybrid Compounds of Group I

Kinetic and Equilibrium Solubility

Modeling of Solubility Data

Lipophilicity

Сorrelation between Biological Activity and Solubility

Thermodynamic Insights into Solubility and Lipophilicity of Hybrid Compounds of Group 2

Kinetic Profiles

Thermodynamic Solubility

Dissolution Thermodynamics

Partition in the 1-Octanol/Buffer pH 7.4 System

Transfer Thermodynamics

Conclusion

References

Chapter 2

Pyrimidine Ring Containing Natural Products and their Biological Importance

1. Introduction

2. Tethered Pyrimidine Alkaloids

2.1. Substituted-Pyrimidine Alkaloids

2.2. Dihydro-Pyrimidine Alkaloids

2.3. Tetrahydro-Pyrimidine Alkaloids

3. Fused Pyrimidine Alkaloids

3.1. Quinazoline Alkaloids

3.2. Dihydropyrrolo-Pyrimidine Alkaloids

3.3. Dihydro-Oxipinopyrazinopyrimidine Alkaloids

4. Nucleosides/Nucleotides

4.1. Pyrimidine Nucleosides/Nucleotides

4.2. Purine Nucleosides/Nucleotides

4.3. Pyrimidine Antibiotics.

4.3.1. Nonglycosylated Pyrimidine Antibiotics

4.3.2. Glycosylated Pyrimidine Antibiotics

5. Pyrimidine Vitamins

6. Pyrimidine Toxins

Future Prospectives

Biographical Sketch

Chapter 3

Regulation of the Pyrimidine Biosynthetic Pathway in the Bacterium Pseudomonas chlororaphis

Methods

Bacterial Strain and Growth Conditions

Isolation and Characterization of a Pyrimidine Auxotroph

Cell Extraction Preparation

Enzymes Assays

Protein Assay, Specific Activity and Statistical Analysis

Results

Discussion

Acknowledgment

Chapter 4

Pyrimidines as Potential Corrosion Inhibitors: Recent Developments and Future Perspectives

An Overview of Corrosion and the Significance of Heterocyclic Corrosion Inhibitors

Pyrimidine and Its Derivatives as Corrosion Inhibitors

Synthesis of Some Pyrimidine-Based Corrosion Inhibitors

Literature Survey and Case Studies

Theoretical Insight on Corrosion Inhibition Property of Pyrimidine-Based Compounds

Challenges and Limitations

Summary and Outlook

Disclaimer

Index

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Notes:

Description based on print version record.

Includes bibliographical references and index.

Other Format:

Print version: Ward, Roger G. Pyrimidines and Their Importance

ISBN:

9798886976632