Glycals and Their Derivatives.

Format:

Book

Author/Creator:

Nazar Hussain.

Contributor:

Kumar, Atul.

Language:

English

Physical Description:

1 online resource (189 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2025.

Summary:

Glycals and Their Derivatives is an essential resource for understanding the emerging applications of carbohydrate-derived unsaturated sugars. Carbohydrates are versatile molecules, abundant in nature, biocompatible, and structurally diverse, with glycals and their derivatives showing remarkable biological activities, including antimicrobial and anticancer effects. It discusses the synthesis, transformations, and applications of glycals, offering valuable insights for researchers and professionals in glycoscience. Key Features:- Comprehensive Coverage: Explores the synthesis and transformation of glycals, glycosides), and 2-C-branched sugars, emphasizing their chemical and biological significance.- Advanced Synthetic Strategies: Discusses recent advances, including metal-catalyzed and metal-free approaches for glycoside synthesis under mild conditions.- Natural Product Synthesis: Highlights the total synthesis of medicinally important molecules derived from glycals.- Cutting-Edge Applications: Examines the role of glycals in creating glycohybrids and glycoconjugates, opening avenues in glycobiology and glycotechnology. Readership: Designed for undergraduate and graduate students, academic researchers, and professionals in the pharmaceutical and chemical industries.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

List of Contributors

Introduction to Glycals

Bindu Tiwari1, Mittali Maheshwari1, Altaf Hussain2, Ram Pratap Pandey1 and Nazar Hussain1,*

INTRODUCTION

PREPARATION OF SIMPLE GLYCALS

SYNTHESIS OF GLYCALS FROM GLYCOSYL SULFOXIDES

Preparation of Pyranoid Glycals

Preparation of Furanoid Glycals

SYNTHESIS OF GLYCALS FROM THIOGLYCOSIDES OR GLYCOSYL SULFONES

SYNTHESIS OF GLYCALS BY ELECTROCHEMICAL METHOD

SYNTHESIS OF GLYCALS USING TITANIUM(III) REAGENT

TRANSFORMATIONS OF GLYCALS

GLYCALS IN SYNTHETIC AND NATURAL PRODUCTS

EXO-GLYCALS

Synthesis of Exo-glycals from Sugar Lactones

Synthesis and Chemoselective Oxidation of Thiomethylphosphono-exo-glycals

Synthesis of Difluoro Exo-glycals

CONCLUSION

REFERENCES

Recent Advances in the Synthesis of O- and S-Glycosides from Glycals

Mittali Maheshwari1, Bindu Tiwari1, Manish Kumar Sharma1 and Nazar Hussain1,*

INTRODUCTION TO O-GLYCOSIDES

HISTORICAL ASPECTS

Medicinal Applications of O-glycosides

Mechanistic Insight into O-glycosylation

Factors Affecting the Stereochemistry of the Glycosides

Neighboring Group Participation

Anomeric Effect

Solvent Effect

Literature on Synthesizing O-glycosides

INTRODUCTION TO S-GLYCOSIDES

Medicinal Applications of S-glycosides

Literature On Synthesizing S-glycosides

Recent Advances in the Synthesis of C-Glycosides Using Glycals and their Derivatives

Manish Kumar Sharma1, Anand Kumar Pandey1, Ram Pratap Pandey1 and Nazar Hussain1,*

SYNTHESIS OF C-GLYCOSIDES USING GLYCALS AND THEIR DERIVATIVES

Ferrier Type C-glycosylation

Transition-metal (TM)-catalyzed C-glycosylation

Palladium-catalyzed C-glycosylation

Cobalt-catalyzed C-glycosylation.

Nickel-catalyzed C-glycosylation

Iridium-Catalyzed C-glycosylation

Other Types of C-glycosylation

Exploring the C-2 Position of Glycals: Structural Insights and Synthetic Applications

Ram Pratap Pandey1, Manish Kumar Sharma1, Anand Kumar Pandey1, Altaf Hussain2 and Nazar Hussain1,*

2-Haloglycals

C-H Activation

1,2-Annulated Sugars

2-Nitroglycals

Cyclopropanated Sugars

ABBREVIATIONS

Total Synthesis of Natural Products and Medicinally Important Molecules from Glycals

Norein Sakander1,2 and Qazi Naveed Ahmed1,2,*

Synthesis of Diospongin A

Synthesis of Bradyrhizose

Synthesis of Bergenin

Total synthesis of (+)-aspicilin

Synthesis of Reblastatin

Synthesis of Cyclopropane Derivative of Spliceostatin A

Synthesis of Papulacandins A-D and its Derivatives

Synthesis of (−)-Hyacinthacine A1

Synthesis of Tricyclic flavonoid

Sporiolide B and its derivatives

Synthesis of Cryptopyranmoscatone

Synthesis of Biologically Potent Molecule: Tetrahydroquinolines

Synthesis of Conduramine F4

Synthesis of Aspergilide A

Synthesis of Vineomycinone B2

Synthesis of Oxadecalin Core of Phomactin A

Synthesis of Peptidomimetics

Synthesis of (−)-steviamine

Synthesis of decytospolide A and B

Synthesis of Spliceostatin G

Subject Index

Back Cover.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9789815322798

9815322796

OCLC:

1507694781