Antimicrobial peptides : functions, mechanisms of action and role in health and disease / Paresh Chandra Ray.

Format:

Book

Author/Creator:

Chandra Ray, Paresh, author.

Series:

Microbiology research advances series.

Microbiology Research Advances

Language:

English

Subjects (All):

Peptide antibiotics--Design.

Peptide antibiotics.

Peptide antibiotics--Research--Methodology.

Physical Description:

1 online resource (252 pages)

Place of Publication:

New York, NY : Nova Science Publishers, Inc., [2021]

Summary:

"The increasing prevalence of antibiotic-resistant bacteria, known as superbugs, has threatened the field of infectious disease medicine over most of the past century. Antimicrobial peptides, a crucial part of innate immunity that exists in most living organisms, have become a central pillar for the next generation of medical challenges for infectious diseases, cancer, and other health problems. The development of new antimicrobial peptides to tackle ongoing superbug infections, cancer and other diseases is a fast-growing research area for chemistry, medical physics, biological science, food and agricultural science and different disciplines of medicine. This volume discusses the basic science behind potential pharmacological agents, which is necessary to understand how these peptides can be used in our daily lives. The book provides a foundation for a wide variety of antimicrobial peptide-based therapeutic approaches, which is invaluable for established scientists, junior researchers, and students involved in basic science, material science, the medical field and different disciplines of engineering. It contains nine chapters written by world leaders in this area, covering basic science and possible therapeutic applications with immense societal implications. Antimicrobial peptides are an exciting new therapeutic agent with promising applications for a wide variety of illnesses"-- Provided by publisher.

Contents:

Intro

Contents

Preface

Chapter 1

Antimicrobial Peptides: Potential as Alternative or Complementary Treatments for Infectious Agents

Abstract

Introduction

Emergence of Antibiotic Resistance and Its Implications

Common Antibiotic Resistant Bacterial Pathogens of Serious Health Concern

Antimicrobial Peptides

Mechanisms of Bioactivity of Peptides

Main Groups of AMPs and Biochemical Factors Relevant to AMP Functionality

AMPs for Control of Biofilm-Forming Bacteria

AMPs for Control of Spore-Forming Bacteria

AMPs in Development for Solitary or Combinatorial Clinical Applications for Infection Control

AMPs for Infection Control in the Agriculture and Food Industry

Conclusion

References

Chapter 2

Multiple Antimicrobial Peptides Conjugated Biochar Based Nanoarchitecture for Combating Superbugs

Scheme for the Development of Single Antimicrobial Peptide Attached Biochar Dots for Combating Superbugs

Design of Multiple Human Host Defense Antimicrobial Peptides Attached Biochar Nanoarchitecture for Combating Drug Resistance Bacteria

Outlook and Perspective

Acknowledgments

Chapter 3

Versatile Biological Properties of Antimicrobial Peptides in Health and Disease

Historic Background

Sources

AMPs from Insects

AMPs from Other Invertebrates

AMPs from Vertebrates

Versatile Biological Properties of Antimicrobial Peptides (AMPs)

Structural Diversity of Antimicrobial Peptides (AMPs)

Mode of Action of Antimicorbial Peptides (AMPs)

Therapeutic Applications

Drug Delivery Activity

Anti-Cancer Activity

Anti-Biofilm Activity

Antibacterial Activity

Immune-Modulatory Activity

Diseases Associated with Antimicrobial Peptides (AMPs)

AMPs in Skin and Inflammatory Disease.

AMPs in Lung and Respiratory Disease

AMPs in Periodontal Disease

AMP in Bowel Disease

AMPs in Cancers

AMPs in Injury, Angiogenesis and Wound Healing

AMPs in Articular Joint Disease

Antimicrobial Peptides and Other Inflammatory Diseases

Challenges to Develop AMPS for Clinical Application

Conclusion and Future Perspectives

Chapter 4

Uperin Antimicrobial Peptides: Structures, Activity, and Amyloid Fibril Formation

Mechanisms of Membrane Disruption by Antimicrobial Peptides

Amyloid Fibril Formation of Peptides and Proteins

Amyloid Fibril-Forming Antimicrobial Peptides

Uperin Peptides

Antimicrobial Activity and Solution Structure of Uperin Peptides

Amyloid Fibril Formation of Uperin Peptides

Molecular Dynamics Simulations of Uperin Peptide Aggregation

Membrane Activity of Uperin Peptides

Cross- Amyloid Fibrillar Structure of Uperin 3.5

Imaging of Uperin 3.5 Fibrils

Functional Amyloid and Uperin Amyloid Fibrils

Chapter 5

The Potential of Antimicrobial Peptides in Breast Cancer Treatment

Mechanism of Action of Antimicrobial Peptides

Antimicrobial Peptides in Breast Cancer Treatment

Tilapia Piscidin 4 (TP4)

Temporin-1CEa

Nisin

Sesquin

PaDef

PvD1

SK84

NRC-03 and NRC-07

Conjugates, Derivatives, and Mimics of Antimicrobial Peptides for Breast Cancer Treatment

(KLAKLAK)2

Ceragenin CSA-13

CM4

PR39

Ixosin-B

NRC-03

Chapter 6

Peptide Conjugated Graphene Based Smart Materials for Antibacterial and Cancer Therapy

Designed of Smart Nanocomposites for Bacteria Eradication.

Graphene Based Smart Nanocomposites for Cancer Treatment

Chapter 7

Antimicrobial Peptide-Modified Nanomaterials for Detection and Extermination of Bacteria

AMP-NP Conjugates in Bacteria Detection and Isolation

Magnetic Nanoparticle-AMP Conjugates

Plasmonic Nanoparticle-AMP Conjugates

Amp-Nanomaterial Conjugates for Exterminating Bacteria

Chapter 8

Antimicrobial Peptide Conjugated Nanostructures for Biosensing and Destruction of Antimicrobial Resistant Microbes

Nanotechnology in Biosensing and Therapeutics

Nanomaterials for biosensing

Gold Nanomaterials

Graphene Oxide

Quantum Dots

Magnetic Nanostructures

Diagnosis and Therapeutic Antimicrobial Application using AMP Conjugated MoS2 Based Nanoplatform

Photothermal Therapy

Photodynamic Therapy

Conclusion and future direction

Chapter 9

Antimicrobial Peptide Attached Gold Nanoparticle Based Theranostic Nanoplatform

Design of Antimicrobial Peptide Attached Nanoparticle Based Nanoplatform for Imaging and Killing of Bacteria

Design of Nanoplatform for Exosome Identification

About the Editor

Index

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Notes:

Description based on print version record.

ISBN:

1-68507-082-5