The chemistry of gallic acid and its role in health and disease / edited by Jeff C. Murdoch.

Format:

Book

Contributor:

Murdoch, Jeff C., editor.

Series:

Chemistry Research and Applications Series

Language:

English

Subjects (All):

Antioxidants--Therapeutic use.

Antioxidants.

Phenols--Physiological effect.

Phenols.

Physical Description:

1 online resource (198 pages)

Edition:

1st ed.

Place of Publication:

New York, New York : Nova Science Publishers, Incorporated, [2023]

Summary:

This book explores the latest developments in gallic acid research and its role in health and disease.

Contents:

Intro

Contents

Preface

Chapter 1

Gallic Acid: From Chemistry to Analysis

Abstract

Abbreviations

Introduction

Chemistry and Physico-Chemical Properties of Gallic Acid

Analytical Perspective of Gallic Acid

Ultraviolet Spectroscopy

Infrared Spectroscopy (IR)

Nuclear Magnetic Resonance (NMR)

Mass Spectrometry (MS)

Thin Layer Chromatography (TLC)

High Performance Thin Layer Chromatography (HPTLC)

High Performance Liquid Chromatography (HPLC)

Conclusion

References

Chapter 2

A New Perspective on the Efficacy of Gallic Acid in the Treatment of Breast Cancer

Source and Chemistry of Gallic Acid

Biological Properties of Gallic Acid

Bioavailability and Toxicity of Gallic Acid

Signs and Symptoms of Breast Cancer [41-47]

Types of Breast Cancer [41-47]

Therapeutic Role of Gallic Acid

Chapter 3

A New Perspective on the Efficacy of Gallic Acid in the Treatment of Lung Cancer

Lung Cancer

Gallic Acid

Chemistry of Gallic Acid

Different Pathways Involved in Mechanism of Action of Gallic Acid

The Tendency of Gallic Acid to Prevent DNA Methylation

Gallic Acid Accelerates EGFR Turnover, Promoting Apoptosis in EGFR-Mutant Non-Small Cell Lung Tumors

Through the JAK/STAT3 Signaling Pathway, Gallic Acid Possesses Anticancer Action and Amplifies the Anticancer Effects of Cisplatin in Non-Small Cell Lung Cancer A549 Cells

The Inhibitory Pathways of Tumor Cell PD-L1 Expression in Non-Small-Cell Lung Cancer (NSCLC) Cells by Natural Bioactive Gallic Acid

Through the Amplification of Glutathione Depletion, MAPK Inhibitors Increase the Mortality of A549 Lung Cancer Cells Caused by Gallic Acid

Apoptosis Induced in H446 Cell Line Through the ROS-Dependent Mitochondrial Apoptotic Pathway.

Conclusion

Chapter 4

A New Perspective on the Efficacy of Gallic Acid Nanoformulation on Colorectal Cancer Treatment

Recent Developments, Impact and Challenges in Nanoformulations

Synthesis Routes of Different Nanoformulations

Dendrimers Synthesis

Divergent Growth Method

Convergent Growth Method

Magnetite Nanocomposite Formulation of Gallic Acid (Fe3O4-PEG-GA) Against Colon Cancer Cells

Gallic Acid and Quercetin Chitosan Nanoparticles for Sustained Release in Treating Colorectal Cancer

Epigallocatechin-3-gallate Nanoparticles

Polymer Nanoparticles Composed with Gallic Acid-Grafted Chitosan and Bioactive Peptides

Gallic Acid-Loaded Sodium Alginate Microspheres

Chitosan and Glyceryl Monooleate Nanostructures Containing Gallic Acid Isolated from Amla Fruit

Gum Arabic-Stabilized Gallic Acid Nanoparticles

Chapter 5

Strategic Approaches of Gallic Acid in Different Disease Conditions

Anticancer Activity

Antioxidant Activity

Antimicrobial Activity

Anti-Diabetic Activity

Anti-Obesity Activity

Anti-Inflammatory Activity

Cardiovascular Activity

Chapter 6

Gallic Acid: A Potential Antidiabetic Agent

Diabetes Mellitus and Related Complications: Oxidative Stress

Hyperglycemia and Oxidative Stress

Insulin Resistance &amp

Oxidative Stress

Gallic Acid: Natural Bioactive Metabolite

Gallic Acid: Natural Antioxidant

Gallic Acid in Plants

Gallic Acid as a Natural Bioactive Metabolite

Gallic Acid as a Versatile Antioxidant Agent

Structure Modification of Gallic Acid

Gallic Acid for Diabetic Therapy

Diabetic Nephropathy

Gallic Acid Derivatives and Gallic Acid

Conclusion.

References

Chapter 7

Gallic Acid: A Potential Anti-Tumor Agent

Gallic Acid as an Anti-Tumor Agent

Ovarian Carcinoma

Colon/Colorectal Cancer

Lymphoma (Lymphatic Cancer)

Prostate Cancer

Breast Cancer

Oral Cancer

Esophageal Cancer

Cervical Cancer

Leukemia

Hepatocellular Carcinoma (HCC)

Melanoma Cells

Bladder Cancer

Chapter 8

In Vitro Anticancer Activity Gallic Acid Nanoparticles on Colon Cancer Cell Colo 205

Materials and Methods

Materials

Plant Material

Soxhlet Extraction Method

Phytochemical Screening

Qualitative Test

Determination of Total Phenolic Content from Amla Extract

Techniques of Isolation and Purification of Bioactive Molecules from Amla Extract [14, 15]

Fractionation of Bioactive Compound by Flash Chromatographic Technique

Gas Chromatography (GC)

Structural Clarification of the Bioactive Molecules [16-18]

UV-Visible Spectroscopy

FTIR Spectroscopy

NMR Spectroscopy of the Isolated Compound

HPLC of Isolated Compounds

HPTLC of the Isolated Compound

Determination of Solubility of the Isolated Compound

Melting Point Determination

Antioxidant Activity by DPPH Method [19]

Formulation of Herbal Nanoparticles [21]

Characterization of Herbal Nanoparticles

Particle Size and Zeta Potential [22]

By FTIR Spectroscopy

Differential Scanning Colorimetry [23]

In Vitro Release Studies [10]

In Vitro Anticancer Activity by MTT Assay [24]

Result and Discussion

Soxhlet Extraction Method [25]

Phytochemical Screening [13]

Qualitative Tests

Total Phenolic Content [26]

Techniques of Isolation and Purification of Bioactive Molecules from Amla Fruit.

Fractionation of Bioactive Compound by Flash Chromatographic Technique

Separation by Using Column Chromatography

Gas Chromatography

Thin Layer Chromatography

Structural Clarification of the Bioactive Molecules

FTIR Spectroscopy of the Isolated Compound

HPLC Analysis of Isolated Compound

Antioxidant Activity by DPPH Method [30]

Formulation of Herbal Nanoparticles [33]

Analysis of Particle Size and Zeta Potential

FTIR of Herbal Nanoparticles [34]

Differential Scanning Calorimetry

In Vitro Release Studies

In Vitro Anticancer Activity by MTT Assay

Chapter 9

Pharmacognosy of Gallic Acid and Its Co-Crystals

Phytosources of Gallic Acid

Pharmacological Activities of Gallic Acid

Structural Aspects of Gallic Acid

Polymorphs, Solvates/Hydrates, Organic Salts and Co- Crystals

Gallic Acid Co- Crystals in Pharmaceutical Research

Biographical Sketches

Index

Blank Page.

Notes:

Includes index.

Description based on print version record.

Other Format:

Print version: Murdoch, Jeff C. The Chemistry of Gallic Acid and Its Role in Health and Disease

ISBN:

9798886977295

OCLC:

1374425741