Novel Drug Delivery Systems (Part 2).

Format:

Book

Author/Creator:

Mundada, Atish S.

Contributor:

Choudhari, Alap.

Language:

English

Physical Description:

1 online resource (254 pages)

Edition:

1st ed.

Place of Publication:

Sharjah : Bentham Science Publishers, 2024.

Summary:

Novel Drug Delivery Systems (Part 2) covers the advanced techniques and innovations transforming pharmaceutical sciences, with a focus on enhancing drug efficacy and patient outcomes. This comprehensive guide explores a wide array of delivery methods, including nasopulmonary, transdermal, ocular, nanotechnology-based, implantable, and controlled-release injectables. Each chapter provides an in-depth analysis of these unique delivery routes, presenting both foundational knowledge and the latest technological advancements in the field. Designed for students, researchers, and professionals in pharmaceuticals and medicine, this book bridges basic concepts with cutting-edge practices, emphasizing the science and impact of controlled drug delivery. Key Features:- Detailed exploration of nasopulmonary, transdermal, ocular, and implantable delivery systems- Insight into nanotechnology's role in drug delivery- Comprehensive coverage of controlled-release injectables Readership:Ideal for students, researchers, and industry professionals seeking to deepen their understanding of advanced drug delivery methods.

Contents:

Intro

Title

Copyright

End User License Agreement

Contents

Foreword

Preface

Dedication

List of Contributors

Nasopulmonary Route of Drug Delivery

Bhushan R. Rane1,*, Akash J. Amkar1 and Ashish S. Jain1

INTRODUCTION

PULMONARY DRUG DELIVERY

Pulmonary Environment

MECHANISM AND PATHWAY OF DRUG ABSORPTION THROUGH PULMONARY ROUTE

Impaction

Sedimentation

Diffusion

RATIONALE FOR SELECTION OF DRUG FOR THE NASOPULMONARY DELIVERY

Ideal Characters for Selection of Drug for Nasal Delivery

Ideal Characteristics for Selection of Drug for Pulmonary Delivery

FACTORS INFLUENCING DRUG ABSORPTION

Factors Affecting Absorption of Drug through Nasal Route

Drug Physicochemical Considerations

Nasal Effect

Delivery Effect

Factors Exert Influence on Absorption through the Pulmonary Route

Mechanical Barrier

Chemical and Immunological Barrier

Behavioural Barrier

STRATEGIES TO IMPROVE ABSORPTION

Strategies or Techniques to Improve Nasal Absorption

Nasal Enzyme Inhibitors

Permeation Enhancers

Prodrug

Particulate Drug Delivery System

Bio-adhesive Polymer for Delivery from Nose to Brain

Strategies to Improve Pulmonary Absorption

Molecular Modification

Polymeric Conjugation

Formulation Technologies

HOW TO DETERMINE DOSE FOR INTRANASAL DELIVERY AND PULMONARY DELIVERY

DOSAGE FORMS AND DEVICES FOR NASOPULMONARY SYSTEMS

Liquid Nasal Formulation

Instillation and Rhinyle Catheter

Compressed Air Nebulizer

Squeeze Bottle

Metered Dose Pump Spray

Powder Dosage Forms

Insufflators

Dry Powder Inhaler (DPIs)

Pressurized MDIs

Nasal Gels

NANOPARTICULATE SYSTEMS FOR NASOPULMONARY DELIVERY

Liposomes

Polymer Micelles

Dendrimers

Inorganic Nanoparticles

Nanocrystals and Nanosuspension

Quantum Dots (QDs).

Protein and Polysaccharides Nanoparticles

RECENT PATENTS ON THE NASOPULMONARY SYSTEM

COVID-19 IMPACT ON THE PULMONARY SYSTEM AND DEVELOPMENT OF INTRANASAL VACCINE

FUTURE PERSPECTIVES

CONCLUSION

REFERENCES

Transdermal Route of Drug Delivery

Lokesh P. Kothari1, Atish S. Mundada1,* and Swaroop R. Lahoti2

Advantages

Limitations

SKIN AS THE PORT OF DRUG ADMINISTRATION

Skin Anatomy

Outermost Layer-The Epidermis

The Dermis

The Hypodermis

Skin Appendages

Biochemistry of the Skin

The Skin Circulatory System

ROUTES OF PENETRATION

PHYSICOCHEMICAL PARAMETERS OF THE DRUG AFFECTING PERCUTANEOUS ABSORPTION

Solubility in the Stratum Corneum

Permeation Across Stratum Corneum

Partitioning

Diffusion Through the Viable Tissue [33]

FACTORS INFLUENCING PERCUTANEOUS ABSORPTION

Condition of the Skin

Thermodynamic Properties of the Medicament

Effect of Moisture

Effect of Vehicles

Effect of Surfactants

Effect of Concentration of Medicament

Effect of pH

SCIENTIFIC REPRESENTATIONS OF SKIN ABSORPTION

COMPONENTS OF TDDS

Backing Substrate

Drug Reservoir Component

Control Membrane

Pressure Sensitive Adhesives

Release Liner

Packing Substrate

SYSTEM DESIGNS FOR TRANSDERMAL PATCHES

Matrix-type Transdermal Patch

Reservoir-type Transdermal Patch

TECHNIQUES AND INSTRUMENTS USED FOR MAKING TRANSDERMAL PATCHES

Lab Scale Techniques

Coating/Spraying Technique

Hand-casting Technique

Hot Melt Extrusion

Large Scale Techniques

Rotary Die-Cutting

Lamination Technique

Solvent Casting/Coating

Instruments for Large Scale

Rotary Die-Cutting Machine

Hot Melt Extrusion Machine

Coating Machine

Lamination Equipment

EVALUATION OF TRANSDERMAL SYSTEMS

Concerns Related to Skin Permeation Studies.

Tissue Culture-derived Skin Equivalents used for Percutaneous Absorption Studies

VARIETY OF PERMEATION STUDY CELLS USED IN LABORATORIES

Franz Diffusion Cell (Vertical)

Horizontal Diffusion Cell

A Flow-thru Cell or In-Line Cell

PERMEABILITY DATA ANALYSIS

CHARACTERIZATION OF TDDS

Dissolution Testing

Thickness

Weight Uniformity

Determining the Drug Content

Content of Moisture

Moisture Absorption

Flatness

Folding Endurance

Tensile Strength

Tack Properties

Thumb Tack Test

The Rolling Ball Test

Peel-and-stick (Quick Stick) Test

Probe Tack Test

Water Vapor Transmission Rate (WVTR)

Swellability

In vitro Drug Release Studies

In vivo Studies

CHALLENGES IN DEVELOPING TDDS

Emerging Technologies Enhancing Drugs Skin Permeation

Passive Approaches

Active Methodologies

Mechanical Methods to Enhance Skin Permeation

NANOTECHNOLOGY IN TRANSDERMAL DRUG DELIVERY

Advantages and Disadvantages of Nanosystems application in TDDS

REGULATORY CONSIDERATION OF TRANSDERMAL FORMULATIONS

Ocular Drug Delivery Systems

Harshilkumar S. Jani1, Yashkumar R. Patel1, Anilkumar K. Prajapati1 and Ketan M. Ranch1,*

Classification of Ocular Dosage Forms

ROUTES OF ADMINISTRATION CONVENTIONAL VS NOVEL ROUTES

CHALLENGES FOR OPHTHALMIC DRUG DELIVERY SYSTEMS

IDEAL CHARACTERISTICS AND IMPORTANT FACTORS AFFECTING OCULAR DRUG DELIVERY

Ideal Requirement for Drug Delivery Systems

Physicochemical Properties of a Drug Candidate

Factors Associated with Formulation

Solution Viscosity

Optimal Partition Coefficient

Particle Size and Shape

Surface Charge of Molecules

Melanin Binding

CONVENTIONAL DOSAGE FORMS

Eye Drops Solution

Suspensions

Emulsions

Eye Ointments.

NOVEL STRATEGIES TO DELIVERY TARGETED OCULAR DRUG DELIVERY

Lipid-based Nano Systems

Solid Lipid Nanoparticles

Nanostructured Lipid Carriers

Polymer-based Nanoparticles

Hydrogel

Metal Nanoparticles

Gold Nanoparticles

Silver Nanoparticles

Contact Lenses

Implants

Microneedles

NANOTECHNOLOGY BASED FDA APPROVED THERAPY

NANOTECHNOLOGY BASED THERAPIES UNDER CLINICAL TRIALS

CHALLENGES AND FUTURE PERSPECTIVES

Nanotechnology as a Novel Approach to Drug Delivery Systems

Vishal C. Gurumukhi1,*, Shailesh S. Chalikwar2 and Ganesh G. Tapadiya3

Rational for Nanotech Delivery System

Features of Nanotechnology in a Delivery System

NANOTECHNOLOGY-BASED DRUG DELIVERY PLATFORM

Polymeric Nanoparticles

Lipid-based Nanoformulations

SLNs and NLCs

Hybrid Nanocarriers

CHARACTERIZATIONS OF THE NANOTECH-BASED DELIVERY SYSTEM

Particle Size (PS) and Particle Size Distribution

Polydispersity Index (PDI)

Surface Charge or Zeta Potential (ZP)

Entrapment Efficiency (EE)

Drug Loading

Polymorphism and Crystallinity

Morphology

Fourier Transform Infrared Spectrophotometry Analysis

THERAPEUTIC APPLICATIONS

Oral Delivery

Dermal Application

Ocular Applications

Parenteral Delivery

Transdermal Delivery

Specific Therapeutic Applications

Therapeutic Applications of Nanotechnology in Cancer

Therapeutic Applications of Nanotechnology in Wound Healing

Therapeutic Applications of Nanotechnology in Alzheimer's Disease

Implantable Drug Delivery

Jagruti L. Desai1,*, Pal B. Patel1, Ashwini D. Patel2, Richa R. Dave1, Swayamprakash Patel1 and Pranav Shah3

Glimpse into Implantable DDS

Advancements in IDDS.

Ideal Properties of Implantable Devices

Benefits of the IDDSs

Disadvantages of IDDSs

Recently Updated FDA-approved Implants

CLASSIFICATION

Non-degradable Implants

The Release Mechanism of Drug from Non-degradable Polymeric Matrices

Reservoir-type Non-degradable Systems

Matrix-type Non-degradable Systems

Non-degradable Implantable Beads

Non-degradable Magnetically Controlled Release Systems

Advantages of Non-degradable IDDSs

Disadvantages of Non-biodegradable Implantable Drug Delivery Systems

Non-Biodegradable Polymers

Biodegradable Implants

Dynamic Pumps

Microelectronics

Osmotic Pumps

Propellent Driven Pump

Electromechanical Systems

Microelectromechanical Systems (MEMs)

Nanoelectromechanical Systems

IMPLANTABLE MEDICAL DEVICES

Pacemakers

Implantable Cardioverter-defibrillator

Neurostimulators

Chip Rx (Small Pill Implants)

APPLICATIONS

Women's Health

Chronic Diseases

Cardiovascular Disease

Cancer

Diabetes

Ocular Therapy

Pain Management

Infectious Diseases (Tuberculosis)

Neurology and Central Nervous System Health

CURRENT CHALLENGES

Controlled-Release Injectables

Alok Kapadia1,* and Atish S. Mundada2

Proteins and Peptides

Vaccines

Gene Therapeutics

INJECTABLE EMULSIONS

Types of Emulsions

Nanoemulsions

Multiple Emulsions

Microemulsions

Preparation of Emulsions

Emulsions for Injectables for Controlled Delivery

Emulsion Stability

INJECTABLE LIPOSOMES

Types of Liposomes

Preparation of Liposomes

Liposome Formation

Sizing of Liposomes

Encapsulation of Drug

Purification

Liposomes for Injectables for Controlled Delivery

INJECTABLE NANOSUSPENSIONS.

Types of Nanoparticles.

Notes:

Description based on publisher supplied metadata and other sources.

Other Format:

Print version: Mundada, Atish S. Novel Drug Delivery Systems (Part 2)

ISBN:

9789815313567

OCLC:

1481988459