Nutritional Epigenomics.

Format:

Book

Author/Creator:

Ferguson, Bradley S.

Series:

Translational Epigenetics Series

Translational Epigenetics Series ; v.Volume 14

Language:

English

Subjects (All):

Epigenetics.

Nutrition.

Physical Description:

1 online resource (506 pages)

Edition:

2nd ed.

Place of Publication:

Chantilly : Elsevier Science & Technology, 2026.

Summary:

Nutritional Epigenomics, Second Edition, a volume in the Translational Epigenetics, offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health, and developmental processes.

Contents:

Front Cover

Nutritional Epigenomics

Copyright

Contents

Contributors

About the editor

1-Introduction

1 - Introduction to nutritional epigenomics

1. Introduction

2. Epigenetic regulators

2.1 DNA methylation

2.2 Histone modification

2.3 RNA-based modifications

3. Transgenerational inheritance

4. Summary

References

2-Epigenetic regulators

2 - DNA methylation and chromatin modifications-updates based on chromatin modifiers

1. Epigenetics and chromatin organization

1.1 Three-dimensional structure of chromatin

2. DNA methylation

2.1 DNA demethylation

2.2 Mitochondrial DNA methylation

3. Histone modifications and their distribution in the genome

3.1 Histone acetylation

3.2 Histone lysine methylation

3.3 PRMTs and histone arginine methylation

3.4 Arginine demethylation

4. Metabolism and epigenetics

4.1 Metabolism and chromatin modifications

4.2 Hypoxia-induced epigenetic changes

5. Concluding remarks

Acknowledgments

3 - Small noncoding RNAs as epigenetic regulators-updates based on our understanding of other noncoding RNAs

2. Canonical small noncoding RNAs

2.1 MicroRNAs (miRNAs)

2.2 Small interfering RNAs (siRNAs)

2.3 PIWI-interacting RNAs (piRNAs)

3. Noncanonical small noncoding RNAs

3.1 tRNA-derived small RNAs (tsRNAs)

3.2 rRNA-derived small RNAs (rsRNAs)

4. High-throughput approaches to profile small noncoding RNAs

3-Epigenomic regulationof disease

4 - The impact of race and ethnicity on the social epigenomic regulation of disease

2. What do we mean when we talk about race and ethnicity?

3. How is genotype related to race and ethnicity?.

4. Differences in the analysis of race and ethnicity in genetic research as compared to epigenetic research

5. Recommendations for considering continental ancestry for studies involving race or ethnicity and DNA methylation

6. Current state of studies on the role of race and ethnicity in the epigenomic regulation of disease

7. Alternative approaches to examining race, ethnicity, and genetics in relation to DNA methylation

8. Summary

Acknowledgements

5 - The epigenomic impact of methylation in metabolic dysfunction and cancer

2. DNA methylation and its role in regulating gene expression

2.1 Enzymes and substrates important in the regulation of DNA methylation

2.1.1 DNMTs-(methylation of DNA)

2.1.2 SAM-(methyl donor) and links with metabolism

2.1.3 TET enzymes-(demethylation) and links with metabolism

2.2 DNMT inhibitors-(inhibition of DNA methyl transferase)

2.2.1 DNMTIs alter cholesterol and lipid metabolism

3. DNA methylation and hypoxia

4. Mutations in tumor suppressors aberrantly regulate metabolites and alter DNA methylation

4.1 LKB1 and LKB2 mutations

4.2 IDH1 and IDH2 mutations

5. Conclusions

6 - The role of DNA/RNA methylation on neurocognitive dysfunctions

1. Brain aging and cognitive dysfunction

2. DNA methylation, brain aging, and cognitive dysfunction

2.1.1 5′-methylcytosine (5-mC)

2.1.2 5′- hydroxymethylcytosine (5-hmC)

2.1.3 Methods to profile the genome-wide DNA pattern

2.2 DNA methylation and brain aging/cognitive dysfunction

3. RNA methylation, brain aging, and cognitive dysfunction

3.1 RNA methylation

3.1.1 5-methylcytidine (5-mC)

3.2 RNA methylation and brain aging/cognitive dysfunction.

4. Interventions and drug development targeting DNA methylation in brain aging/cognitive dysfunction

4.1 Interventions

4.2 Epigenetic drug development

5. Perspectives and challenges

5.1 The complexity of transcriptional regulation by DNA methylation

5.2 Elucidating the functional significance of DNA methylation

5.3 Interplay of DNA methylation and histone modification

5.4 Examine RNA methylation (m5C) and its role in brain aging and cognitive dysfunction

7 - Histone acylation in the epigenomic regulation of insulin action and metabolic disease

2. Insulin signaling: An outlook

3. The structure of chromatin: General notions

3.2 Histone β-hydroxybutyrylation

3.3 Histone 2-hydroxyisobutyrylation

3.4 Histone propionylation, butyrylation, crotonylation

3.4.1 Histone propionylation

3.4.2 Histone butyrylation

3.4.3 Histone crotonylation

3.5 Histone succinylation and malonylation

3.5.1 Histone succinylation

3.5.2 Histone malonylation

3.6 Histone lysine benzoylation-linking nutritional additives to epigenetics

4. The interaction between insulin signaling and histone acetylation/acylations

4.1 The epigenetic control of insulin-regulated genes

4.2 Epigenetic alterations in type 2 diabetes and in insulin resistance

4.3 Histone acetylation in pancreatic beta cells

5. Conclusions: Importance of histone acetylation/acylation in the modulation of insulin action and future challenges

8 - Cancer and noncoding RNAs

2. MicroRNA

2.1 miRNA biogenesis and function

2.2 Dysregulated miRNAs in human cancers

2.3 Causes of miRNA dysregulation in cancer

2.4 The role of miRNAs in cancer hallmarks

2.4.1 Regulation of cell proliferation by miRNAs.

2.4.2 Activation of invasion and metastasis by miRNAs

2.4.3 Resistance to cell death by miRNAs

2.4.4 Induction of angiogenesis by miRNAs

2.5 MiRNA-targeting therapeutics

3. Long noncoding RNA

3.1 LncRNA classification, biogenesis, and function

3.2 The role of lncRNAs in cancer hallmarks

3.2.1 Sustained proliferative signaling by lncRNAs

3.2.2 Evasion of growth suppressors by lncRNAs

3.2.3 Enabling replicative immortality by lncRNAs

3.2.4 Activation of invasion and metastasis by lncRNAs

3.2.5 Induction of angiogenesis by lncRNAs

3.2.6 Resistance to cell death by lncRNAs

4. tRNA-derived small noncoding RNA (tsRNA)

4.1 Classification, biogenesis, and function of tsRNAs

4.2 The role of tsRNAs in the hallmarks of cancer

4.2.1 3′ U tRF

4.2.2 tRF

4.2.3 tRH

5. Circular RNA (circRNA)

5.1 Formation of circRNAs

5.2 Functional mechanism of circRNAs

5.3 The role of circRNAs in cancer hallmarks

6. Conclusions

4-Nutrition, epigenetics,and transgenerationalinheritance

9 - Race in the social-epigenomic regulation during early development

2. Racial disparity and environment-epigenetics (humans)

3. Racial disparity and environment-epigenetics (animal)

4. Nature versus nurture

4.1 Human studies of nature versus nurture

4.2 Animal studies of nature versus nurture

5. Glucocorticoid biology: A paradigm for health disparities and epigenetics

6. Summary

10 - Maternal nutrition, epigenetic programming, and metabolic diseases

2. Epigenetic mechanism and metabolic disease

2.1 DNA methylation and metabolic disease

2.2 Histone modification and metabolic disease

3. Placental nutrient transfer

4. Epigenetic modulation in maternal-fetal microbiota by maternal diet.

5. Maternal supplementation and epigenetic regulation during pregnancy

5.1 Methyl donors (vitamin B group and choline)

5.2 Vitamin C

5.3 Minerals

5.4 Probiotics

6. Conclusion

Funding

11 - Epigenetic inheritance of metabolic signals

2. Evidence for inter- and transgenerational epigenetic inheritance in response to dietary exposure and metabolic perturbation ...

3. Evidence for inter- and transgenerational transmission from dietary exposure and metabolic perturbations in humans

4. How metabolic signals regulate the epigenome

4.1 Methylation

4.2 Acetylation

4.3 Hormones

4.3.1 Nuclear receptors

5. Metabolic evidence from RNA

6. Impact of the microbiome

7. Lipids in epigenetic inheritance

8. Conclusion

12 - The paternal diet regulates the offspring epigenome and health

2. The effects of paternal diets on offspring and epigenetic inheritance

2.1 Human studies

2.2 Animal studies

3. The possible mechanisms

3.1 DNA modifications

3.2 Histone modifications

3.3 RNA and RNA modifications

4. Present and future perspectives

5-Nutritionalepigenomics andthe circadian clock

13 - The interplay between diet, epigenetics, and the circadian clock

2. Molecular mechanisms of the mammalian circadian oscillator

3. The circadian clock and energy metabolism

4. Epigenetic regulation integrates the circadian clock and energy metabolism

5. Diet and the clock: Linked by epigenetics?

14 - Epigenetic regulation of the fetal circadian clock: Implications for nutritional programming of circadian and ...

2. Circadian rhythms

3. Circadian clocks and metabolism

4. Fetal circadian development.

5. Maternal nutritional signals alter fetal molecular clocks.

Notes:

Description based on publisher supplied metadata and other sources.

Part of the metadata in this record was created by AI, based on the text of the resource.

ISBN:

9780443155734

OCLC:

1595734870