1 option
Tumor suppressor genes / Yue Cheng.
- Format:
- Book
- Author/Creator:
- Cheng, Yue, Editor.
- Language:
- English
- Subjects (All):
- Antioncogenes.
- Physical Description:
- 1 online resource (x, 332 pages) : illustrations
- Place of Publication:
- IntechOpen 2012
- Rijeka, Croatia : InTech, [2012]
- Language Note:
- English
- Summary:
- Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.
- Notes:
- Description based on: online resource; title from PDF information screen (InTech, viewed October 10, 2022).
- ISBN:
- 9789535167440
- 9535167448
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.