Oligonucleotides : overview and applications / edited by Arghya Sett.

Format:

Book

Contributor:

Sett, Arghya, editor.

Language:

English

Subjects (All):

Diagnosis, Laboratory.

Medical laboratory technology.

Physical Description:

1 online resource (110 pages)

Place of Publication:

London : IntechOpen, 2023.

Summary:

Oligonucleotide-based diagnostics and therapeutics are attracting attention from the scientific community. In recent years, the range of applications for oligonucleotides has broadened in innovative and creative directions, such as disease diagnostics, cancer prognosis and more. It played an important role during the COVID pandemic in rapid PCR testing as well as modified mRNA-based life-saving vaccines. Various modifications of natural nucleotide bases have been evaluated for several theranostic applications. The development of nucleotide and oligonucleotide therapeutics has been growing in importance over the past few decades. This book examines new developments in oligonucleotide-based research and provides a comprehensive overview of the state of the art in this exciting discipline.

Contents:

1. Introductory Chapter: Oligonucleotides - Overview and Applications

2. The Importance of the Fifth Nucleotide in DNA: Uracil

3. Modified (2',5')Oligonucleotides: The Influence of Structural and Steriochemical Factors on Biological and Immunotropic Activity

4. Combinatorial Oligonucleotide FISH (COMBO-FISH): Computer Designed Probe Sets for Microscopy Research of Chromatin in Cell Nuclei

5. The Natural Antisense Transcript-Targeted Regulation Technology Using Sense Oligonucleotides and Its Application

6. Identification of RNA Oligonucleotide and Protein Interactions Using Term Frequency Inverse Document Frequency and Random Forest.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

1-80355-628-5