Zinc signaling in physiology and pathogenesis / edited by Toshiyuki Fukada, Taiho Kambe.

Format:

Book

Contributor:

Fukada, Toshiyuki, editor.

Kambe, Taiho, editor.

Language:

English

Subjects (All):

Signals and signaling.

Physical Description:

1 online resource (ix, 279 pages) : illustrations, diagrams

Place of Publication:

[Place of publication not identified] : MDPI AG - Multidisciplinary Digital Publishing Institute, 2018.

Language Note:

In English.

Summary:

The essential trace element zinc plays indispensable roles in multiple cellular processes. It regulates a great number of protein functions, including transcription factors, enzymes, adapters, and growth factors as a structural and/or catalytic factor. Recent studies have highlighted another function of zinc as an intra- and intercellular signaling mediator, which became recognized as the "zinc signal". Indeed, zinc regulates cellular signaling pathways, which enable conversion of extracellular stimuli to intracellular signals, and controls various intracellular and extracellular events, and thus zinc mediates communication between cells. The zinc signal is essential for physiology, and its dysregulation causes a variety of diseases, such as diabetes, cancer, osteoarthritis, dermatitis, and dementia. This Special Issue focuses on crucial roles of zinc signaling in biological processes in molecular and physiological basis, addressing the future directions and questions underlying this unique phenomenon. Because there is growing interest and attention in physiopathological contribution of zinc signal, we believe this Special Issue will provide very timely information on it and thus should appeal to a wide range of readers.

Notes:

Description based on: online resource; title from PDF information screen (MDPI AG - Multidisciplinary Digital Publishing Institute, viewed February 21, 2023.).