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Coarse-grained modelling of DNA and DNA self-assembly : doctoral thesis accepted650 0 by the University of Oxford, UK / Thomas E. Ouldridge.
Springer Nature - Springer Physics and Astronomy eBooks 2012 English International Available online
View online- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Ouldridge, Thomas E.
- Series:
- Springer theses.
- Springer theses, 2190-5053
- Language:
- English
- Subjects (All):
- DNA.
- Self-assembly (Chemistry).
- Physical Description:
- 1 online resource (179 p.)
- Edition:
- 1st ed. 2012.
- Place of Publication:
- Heidelberg [Germany] : Springer, 2012.
- Language Note:
- English
- Summary:
- This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
- Contents:
- A Novel DNA Model
- Methods
- Finite Size Effects
- Structural and Mechanical Properties of Model DNA
- Thermodynamic Properties of Model DNA
- Modelling DNA Tweezers
- Modelling a DNA Walker.
- Notes:
- Description based upon print version of record.
- Thesis (doctoral)--University of Oxford.
- Includes bibliographical references.
- ISBN:
- 1-283-63035-4
- 9786613942807
- 3-642-30517-2
- OCLC:
- 800058143
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