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Seldin and Giebisch's The kidney : physiology and pathophysiology.
- Format:
- Book
- Author/Creator:
- Alpern, Robert J., Editor.
- Standardized Title:
- Kidney (Seldin and Giebisch)
- Language:
- English
- Subjects (All):
- Kidneys--Physiology.
- Kidneys.
- Kidneys--Pathophysiology.
- Kidneys--Diseases.
- Kidney Diseases.
- Medical Subjects:
- Kidney Diseases.
- Physical Description:
- 1 online resource (2830 pages) : illustrations (some in color)
- Edition:
- Sixth edition / edited by Robert J. Alpern, Michael J. Caplan, Orson W. Moe, Susan E. Quaggin.
- Other Title:
- Kidney
- Place of Publication:
- Elsevier Science & Technology 2026
- Summary:
- Seldin and Giebisch's The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases.
- Contents:
- List of contributors
- Preface
- 1. Epithelial cell structure and polarity
- 2. Mechanisms of ion and water transport across cell membranes and epithelia
- 3. Renal ion-translocating ATPases
- 4. Cell volume control
- 5. Solute transport, energy consumption and production in the kidney
- 6. Electrophysiological analysis of transepithelial transport
- 7. Renal ion channels, electrophysiology of transport and channelopathies
- 8. Microvascular permeability and the exchange of water and solutes across microvascular walls
- 9. Renal cilia structure, function, and physiology
- 10. Intercellular junctions and cell-matrix interactions
- 11. Principles of cell signaling
- 12. Scaffolding proteins in transport regulation
- 13. The renin-angiotensin system
- 14. Neural control of renal function
- 15. Eicosanoids and renal function
- 16. Extracellular nucleotides, metabolites, and renal function
- 17. Structural organization of the mammalian kidney
- 18. Biophysical basis of glomerular filtration
- 19. Glomerular cell biology
- 20. Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion
- 21. Vasculature of the kidney cortex and medulla
- 22. The development of the kidney
- 23. Molecular and cellular mechanisms of glomerular capillary development
- 24. Epithelial Na + channels
- 25. Anion channels
- 26. Physiology and pathophysiology of the NaCl cotransporters in the kidney
- 27. Balance and the pathophysiology of acid-base, fluid, and electrolyte disorders
- 28. Sodium and chloride transport in the proximal tubule
- 29. Mineralocorticoid action in the aldosterone-sensitive distal nephron
- 30. Genetic disorders of renal salt homeostasis and blood pressure
- 31. Pathophysiology of sodium retention and wastage
- 32. Physiology and pathophysiology of hypertension
- 33. Aquaporin water channels in mammalian kidney
- 34. Thirst and vasopressin
- 35. The urine-concentrating mechanism and urea transporters
- 36. Hyponatremia
- 37. Hypernatremic states
- 38. The function and regulation of renal K + channels
- 39. Extrarenal potassium metabolism
- 40. Regulation of K⁺ excretion
- 41. Physiopathology of potassium deficiency
- 42. Clinical disorders of hyperkalemia
- 43. Intracellular pH homeostasis
- 44. SLC4 sodium-coupled bicarbonate and carbonate transporters
- 45. Anion exchangers of the SLC4 gene family
- 46. Cellular mechanisms of renal tubular acidification
- 47. Renal ammonium ion production and transport
- 48. Clinical syndromes of metabolic alkalosis
- 49. Clinical syndromes of metabolic acidosis
- 50. Respiratory acid-base disorders
- 51. Mechanisms and disorders of magnesium metabolism
- 52. Calcium channels
- 53. The calcium-sensing receptor
- 54. Renal calcium metabolism
- 55. Kidney stones
- 56. Proximal tubular handling of phosphate
- 57. Clinical disturbances of phosphate homeostasis
- 58. Glucose reabsorption in the kidney
- 59. Kidney transport of amino acids and oligopeptides and aminoacidurias
- 60. Renal filtration, transport, and metabolism of albumin and albuminuria
- 61. Physiologic principles in the clinical evaluation of electrolyte, water, and acid-base disorders
- 62. Acute kidney injury biomarkers
- 63. Pathophysiology of acute kidney injury
- 64. Ischemic renal disease
- 65. Pathophysiology and pathogenesis of diabetic kidney disease
- 66. Autosomal dominant polycystic kidney disease
- 67. Renal physiology and disease in pregnancy
- 68. Glomerular disorders
- 69. Immunologic mechanisms of vasculitis
- 70. Genetic abnormalities in glomerular function
- 71. Mechanisms of drug nephrotoxicity
- 72. Role of proteinuria in the progression of renal disease
- 73. Oxidative stress and signaling in renal physiology and kidney diseases
- 74. Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease
- 75. Individualizing the dialysate to address electrolyte disturbances in the dialysis patient
- 76. Mechanisms of allograft rejection
- 77. Homeostasis of solute and water by the transplanted kidney.
- Notes:
- Includes bibliographical references.
- Online resource; title from front matter (Elsevier ClinicalKey, viewed August 21 2026).
- ISBN:
- 0-12-815390-3
- 0-12-815389-X
- OCLC:
- 1591757969
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