Utility of polygenic risk score (PRS) for AD and related dementia.

Format:

Video

Contributor:

Escott-Price, Valentina, speaker.

Language:

English

Subjects (All):

Alzheimer's disease--Genetic aspects.

Alzheimer's disease.

Risk assessment--Statistical methods.

Risk assessment.

Physical Description:

1 online resource

Place of Publication:

[Place of publication not identified]: Henry Stewart Talks Ltd, 2026.

Contents:

Introduction

Genetics of Alzheimer’s disease (AD)

Alzheimer’s disease genome-wide association studies (GWAS)

Heritability of Alzheimer's disease

Genetics only explains a portion of the risk for developing AD

APOE and age at clinical onset

Polygenic risk score

What is a polygenic disease?

Polygenic risk score definition

Alzheimer’s diseases is a polygenic disease

Predictive accuracy for 3,049 AD cases vs. 1,554 controls

Polygenic or oligogenic Alzheimer’s disease?

PRS prediction accuracy in ADNI data

Sample of screened aged-matched or path-confirmed 271 cases and 278 controls

Pitfalls of predicting age-related traits by polygenic risk scores

Pitfall 1: Russian-doll-like GWAS

Methodology to calculate PRS

Pitfall 2: uncertainty in individual PRS estimation

Uncertainty in PRS estimation

Pitfall 3: GWAS settings and interpretation in neurodegenerative disorders

Conclusion

Financial disclosures.

Notes:

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