Principles of neural science / Eric R. Kandel, James H. Schwartz, Thomas M. Jessell.

Format:

Book

Contributor:

Kandel, Eric R., Contributor.

Series:

Neurology Collection

McGraw-Hill's AccessMedicine

Language:

English

Subjects (All):

Biological Science Disciplines.

Psychophysiology.

Disease.

Psychological Phenomena and Processes.

Nervous System.

Natural Science Disciplines.

Psychiatry and Psychology.

Anatomy.

Behavioral Sciences.

Behavioral Disciplines and Activities.

Disciplines and Occupations.

Mental Processes.

Central Nervous System.

Physiology.

Nervous System Diseases.

Neuropsychology.

Medical Subjects:

Biological Science Disciplines.

Psychophysiology.

Disease.

Psychological Phenomena and Processes.

Nervous System.

Natural Science Disciplines.

Psychiatry and Psychology.

Anatomy.

Behavioral Sciences.

Behavioral Disciplines and Activities.

Disciplines and Occupations.

Mental Processes.

Central Nervous System.

Physiology.

Nervous System Diseases.

Neuropsychology.

Physical Description:

1 online resource (1760 pages)

Edition:

Fifth edition.

Place of Publication:

[Place of publication not identified] McGraw Hill 2013.

Language Note:

English

Summary:

The field's definitive work from a Nobel Prize-winning author 900 full-color illustrations Principles of Neural Science, 5e describes our current understanding of how the nerves, brain, and mind function. From molecules to anatomic structures and systems to cognitive function, this comprehensive reference covers all aspects of neuroscience. Widely regarded as the field's cornerstone reference, the fifth edition is highlighted by more than 900 full-color illustrations. The fifth edition has been completely updated to reflect the tremendous amount of new research and development in neuroscience in the last decade. Lead author Eric Kandel was awarded the Nobel Prize in Physiology or Medicine in 2000.

Contents:

Intro

Contents-

Preface

Acknowledgments

Contributors

Part I: Overall Perspective

1 The Brain and Behavior

Two Opposing Views Have Been Advanced on the Relationship Between Brain and Behavior

The Brain Has Distinct Functional Regions

The First Strong Evidence for Localization of Cognitive Abilities Came from Studies of Language Disorders

Affective States Are Also Mediated by Local, Specialized Systems in the Brain

Mental Processes Are the End Product of the Interactions Between Elementary Processing Units in the Brain

Selected Readings

References

2 Nerve Cells, Neural Circuitry, and Behavior

The Nervous System Has Two Classes of Cells

Each Nerve Cell Is Part of a Circuit That Has One or More Specific Behavioral Functions

Signaling Is Organized in the Same Way in All Nerve Cells

Nerve Cells Differ Most at the Molecular Level

Neural Network Models Simulate the Brain's Parallel Processing of Information

Neural Connections Can Be Modified by Experience

3 Genes and Behavior

Genes, Genetic Analysis, and Heritability in Behavior

The Nature of the Gene

Genes Are Arranged on Chromosomes

The Relationship Between Genotype and Phenotype

Genes Are Conserved Through Evolution

The Role of Genes in Behavior Can Be Studied in Animal Models

Genetic Studies of Human Behavior and Its Abnormalities

Psychiatric Disorders and the Challenge of Understanding Multigenic Traits

An Overall View

Glossary

Part II: Cell and Molecular Biology of the Neuron

4 The Cells of the Nervous System

Protein Particles and Organelles Are Actively Transported Along the Axon and Dendrites

Proteins Are Made in Neurons as in Other Secretory Cells

Surface Membrane and Extracellular Substances Are Recycled in the Cell.

Glial Cells Play Diverse Roles in Neural Function

5 Ion Channels

Rapid Signaling in the Nervous System Depends on Ion Channels

Ion Channels Are Proteins That Span the Cell Membrane

Currents Through Single Ion Channels Can Be Recorded

Ion Channels in All Cells Share Several Characteristics

The Structure of Ion Channels Is Inferred from Biophysical, Biochemical, and Molecular Biological Studies

Ion Channels Can Be Grouped into Gene Families

The Closed and Open Structures of Potassium Channels Have Been Resolved by X-Ray Crystallography

The Structural Basis of Chloride Selectivity Reveals a Close Relation Between Ion Channels and Ion Transporters

6 Membrane Potential and the Passive Electrical Properties of the Neuron

The Resting Membrane Potential Results from the Separation of Charge Across the Cell Membrane

The Resting Membrane Potential Is Determined by Nongated and Gated Ion Channels

The Balance of Ion Fluxes That Maintains the Resting Membrane Potential Is Abolished During the Action Potential

The Contributions of Different Ions to the Resting Membrane Potential Can Be Quantified by the Goldman Equation

The Functional Properties of the Neuron Can Be Represented as an Electrical Equivalent Circuit

The Passive Electrical Properties of the Neuron Affect Electrical Signaling

7 Propagated Signaling: The Action Potential

The Action Potential Is Generated by the Flow of Ions Through Voltage-Gated Channels

Variations in the Properties of Voltage-Gated Ion Channels Expand the Signaling Capabilities of Neurons

The Mechanisms of Voltage-Gating and Ion Permeation Have Been Inferred from Electrophysiological Measurements.

Voltage-Gated Potassium, Sodium, and Calcium Channels Stem from a Common Ancestor and Have Similar Structures

Part III: Synaptic Transmission

8 Overview of Synaptic Transmission

Synapses Are Either Electrical or Chemical

Electrical Synapses Provide Instantaneous Signal Transmission

Chemical Synapses Can Amplify Signals

9 Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission

The Neuromuscular Junction Is a Well-Studied Example of Directly Gated Synaptic Transmission

The Motor Neuron Excites the Muscle by Opening Ligand-Gated Ion Channels at the End-Plate

The Current Through Single Acetylcholine Receptor-Channels Can Be Measured Using the Patch Clamp

The Molecular Properties of the Acetylcholine Receptor-Channel Are Known

Postscript: The End-Plate Current Can Be Calculated from an Equivalent Circuit

10 Synaptic Integration in the Central Nervous System

Central Neurons Receive Excitatory and Inhibitory Inputs

Excitatory and Inhibitory Synapses Have Distinctive Ultrastructures

Excitatory Synaptic Transmission Is Mediated by Ionotropic Glutamate Receptor-Channels That Are Permeable to Sodium and Potassium

Inhibitory Synaptic Action Is Usually Mediated by Ionotropic GABA and Glycine Receptor-Channels That Are Permeable to Chloride

Ionotropic Glutamate, GABA, and Glycine Receptors Are Transmembrane Proteins Encoded by Two Distinct Gene Families

Excitatory and Inhibitory Synaptic Actions Are Integrated by the Cell into a Single Output

11 Modulation of Synaptic Transmission: Second Messengers.

The Cyclic AMP Pathway Is the Best Understood Second-Messenger Signaling Cascade Initiated by G Protein-Coupled Receptors

The Second-Messenger Pathways Initiated by G Protein-Coupled Receptors Share a Common Molecular Logic

Transcellular Messengers Are Important for Regulating Presynaptic Function

A Family of Receptor Tyrosine Kinases Mediates Some Metabotropic Receptor Effects

The Physiological Actions of Ionotropic and Metabotropic Receptors Differ

Synaptic Actions Mediated by Phosphorylation Are Terminated by Phosphoprotein Phosphatases

Second Messengers Can Endow Synaptic Transmission with Long-Lasting Consequences

12 Transmitter Release

Transmitter Release Is Regulated by Depolarization of the Presynaptic Terminal

Release Is Triggered by Calcium Influx

Transmitter Is Released in Quantal Units

Transmitter Is Stored and Released by Synaptic Vesicles

Exocytosis of Synaptic Vesicles Relies on a Highly Conserved Protein Machinery

Modulation of Transmitter Release Underlies Synaptic Plasticity

13 Neurotransmitters

A Chemical Messenger Must Meet Four Criteria to Be Considered a Neurotransmitter

Only a Few Small-Molecule Substances Act as Transmitters

Small-Molecule Transmitters Are Actively Taken Up into Vesicles

Many Neuroactive Peptides Serve as Transmitters

Peptides and Small-Molecule Transmitters Differ in Several Ways

Peptides and Small-Molecule Transmitters Coexist and Can Be Co-released

Removal of Transmitter from the Synaptic Cleft Terminates Synaptic Transmission

14 Diseases of the Nerve and Motor Unit

Disorders of the Peripheral Nerve, Neuromuscular Junction, and Muscle Can Be Distinguished Clinically.

A Variety of Diseases Target Motor Neurons and Peripheral Nerves

Diseases of the Neuromuscular Junction Have Multiple Causes

Diseases of Skeletal Muscle Can Be Inherited or Acquired

Postscript: Diagnosis of Motor Unit Disorders Is Aided by Laboratory Criteria

Part IV: The Neural Basis of Cognition

15 The Organization of the Central Nervous System

The Central Nervous System Consists of the Spinal Cord and the Brain

The Major Functional Systems Are Similarly Organized

The Cerebral Cortex Is Concerned with Cognition

Subcortical Regions of the Brain Are Functionally Organized into Nuclei

Modulatory Systems in the Brain Influence Motivation, Emotion, and Memory

The Peripheral Nervous System Is Anatomically Distinct from the Central Nervous System

16 The Functional Organization of Perception and Movement

Sensory Information Processing Is Illustrated in the Somatosensory System

The Thalamus Is an Essential Link Between Sensory Receptors and the Cerebral Cortex for All Modalities Except Olfaction

Sensory Information Processing Culminates in the Cerebral Cortex

Voluntary Movement Is Mediated by Direct Connections Between the Cortex and Spinal Cord

17 From Nerve Cells to Cognition: The Internal Representations of Space and Action

The Major Goal of Cognitive Neural Science Is to Understand Neural Representations of Mental Processes

The Brain Has an Orderly Representation of Personal Space

The Internal Representation of Personal Space Can Be Modified by Experience

Extrapersonal Space Is Represented in the Posterior Parietal Association Cortex

Much of Mental Processing Is Unconscious.

Is Consciousness Accessible to Neurobiological Analysis?.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Description based on publisher supplied metadata and other sources.

ISBN:

1-283-65624-8

0-07-181001-3

OCLC:

1027191624