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Applied biopharmaceutics & pharmacokinetics
- Format:
- Book
- Author/Creator:
- Shargel, Leon, Author.
- Series:
- McGraw-Hill's AccessPharmacy
- Language:
- English
- Subjects (All):
- Biopharmaceutics.
- Pharmacokinetics.
- Pharmacology.
- Metabolism.
- Kinetics.
- Pharmacological Phenomena.
- Models, Theoretical.
- Biochemical Phenomena.
- Health Occupations.
- Investigative Techniques.
- Biological Science Disciplines.
- Physiological Phenomena.
- Chemical Phenomena.
- Natural Science Disciplines.
- Models, Chemical.
- Medical Subjects:
- Pharmacology.
- Metabolism.
- Kinetics.
- Pharmacological Phenomena.
- Models, Theoretical.
- Biochemical Phenomena.
- Health Occupations.
- Investigative Techniques.
- Biological Science Disciplines.
- Physiological Phenomena.
- Chemical Phenomena.
- Natural Science Disciplines.
- Models, Chemical.
- Pharmacokinetics.
- Biopharmaceutics.
- Physical Description:
- 1 online resource (xviii, 811 p. ) ill., figs., tables.
- Edition:
- 6th ed.
- Other Title:
- Applied biopharmaceutics and pharmacokinetics
- Place of Publication:
- New York : McGraw-Hill Medical, 2012.
- Language Note:
- English
- Summary:
- A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics "The field s leading text for more than three decades" "Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition" provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy."
- Contents:
- Introduction to biopharmaceutics and pharmacokinetics
- Mathematic fundamentals in pharmacokinetics
- One-compartment open model: intravenous bolus administration
- Multicompartmental models : intravenous bolus administration
- Intravenous infusion
- Drug elimination and clearance
- Pharmacokinetics of oral absorption
- Multiple-dosage regimens
- Nonlinear pharmacokinetics
- Physiologic drug distribution and protein binding
- Drug elimination and hepatic clearance
- Pharmacogenetics
- Physiologic factors related to drug absorption
- Biopharmaceutic considerations in drug product design and in vitro drug product performance
- Drug product performance, in vivo : bioavailability and bioequivalence
- Impact of drug product quality and biopharmaceutics on clinical efficacy
- Modified-release drug products
- Targeted drug delivery systems and biotechnology products
- Relationship between pharmacokinetics and pharmacodynamics
- Application of pharmacokinetics to clinical situations
- Dosage adjustment in renal and hepatic disease.
- Notes:
- Bibliographic Level Mode of Issuance: Monograph
- Description based on cover image and table of contents, viewed on Oct. 24, 2016.
- ISBN:
- 0-07-160393-X
- OCLC:
- 1058863422
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