Analysis of Data from Randomized Controlled Trials : A Practical Guide / by Jos W.R. Twisk.

Format:

Book

Author/Creator:

Twisk, Jos W. R., 1962- author.

Language:

English

Subjects (All):

Statistics.

Clinical medicine--Research.

Clinical medicine.

Biometry.

Experimental design.

Statistical Theory and Methods.

Clinical Research.

Biostatistics.

Design of Experiments.

Local Subjects:

Statistical Theory and Methods.

Clinical Research.

Biostatistics.

Design of Experiments.

Physical Description:

1 online resource (167 pages)

Edition:

1st ed. 2021.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2021.

Summary:

This book provides a practical guide to the analysis of data from randomized controlled trials (RCT). It gives an answer to the question of how to estimate the intervention effect in an appropriate way. This problem is examined for different RCT designs, such as RCTs with one follow-up measurement, RCTs with more than one follow-up measurement, cluster RCTs, cross-over trials, stepped wedge trials, and N-of-1 trials. The statistical methods are explained in a non-mathematical way and are illustrated by extensive examples. All datasets used in the book are available for download, so readers can reanalyse the examples to gain a better understanding of the methods used. Although most examples are taken from epidemiological and clinical studies, this book is also highly recommended for researchers working in other fields.

Contents:

Introduction

Analysis of RCT data with one follow-up measurement

Analysis of RCT data with more than one follow-up measurement

Analysis of data from a cluster RCT

Analysis of data from a cross-over trial

Analysis of data from stepped wedge trials

Analysis of data from N-of-1 trials

Dichotomous outcomes

What to do when only a baseline measurement is available

Sample size calculations.

Notes:

Includes bibliographical references and index.

ISBN:

9783030818654

3030818659

OCLC:

1277277639