Transcriptional control of neural crest development / Brian L. Nelms and Patricia A. Labosky.

Format:

Book

Author/Creator:

Nelms, Brian L.

Contributor:

Labosky, Patricia A.

Series:

Colloquium series on developmental biology ; #1.

Colloquium series on developmental biology ; bk. #1

Language:

English

Subjects (All):

Neural crest.

Genetic transcription--Regulation.

Genetic transcription.

Transcription factors.

Physical Description:

1 online resource (246 p.)

Place of Publication:

[San Rafael, Calif.?] : Morgan & Claypool, 2010.

Language Note:

English

Summary:

The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecified, nonmigratory population to a wide array of dynamic, differentiated cell types--some of which retain stem cell characteristics presumably to replenish these derivatives-- requires a complex network of molecular switches to control the gene programs giving these cells their defining structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specific transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state.

Contents:

1. Introduction

The role of transcriptional regulation in development

Neural crest cells have remarkable developmental plasticity

The role of transcription factors in neural crest stem cells and induced pluripotent stem cells

NC misregulation in disease states

Reviewing current knowledge of NC transcriptional control

2. AP genes

AP-1

AP-2a (Tcfap2a)

Mouse AP-2a

Chicken AP-2a

Zebrafish AP-2a mutants

Xenopus AP2a

Regulation of AP-2

AP-2 targets

AP-2 binding sites

AP-2 as an NC marker

AP-2B (Tcfap2b)

AP-2y (Tcfap2c)

AP-2d (Tcfap2d) and AP-2e (Tcfap2e)

3. bHLH genes

Ascl1

Ascl1 in the sympathoadrenal lineage

Regulation of Ascl1 by BMP, cAMP, and notch signaling

Ascl1 interaction with other transcription factors and targets

Ascl1 in human disease

Hand1

Hand2

Hand2 in the Pharyngeal Arches and Derivatives

Hand2 in the Heart

Hand2 in the Sympathetic Nervous System

Hand2 in the Enteric Nervous System

Hand2 in Neuroblastoma

Hand2 Partners and Function

Mitf

Targets of Mitf

Regulation of Mitf by Sox10 and Pax3

Regulation of Zebrafish Mitf by Foxd3

Mitf Downstream of Wnt Signaling

Posttranslational Regulation of Mitf

Mitf in Human Disease

Myc

Mycn

Tcf3, Tcf4, and Tcf12 (E Proteins)

Twist1

Twist1 in the Cranial Mesenchyme and Pharyngeal Arches

Twist1 in the Skull Vault

Twist in Zebrafish and Xenopus

Twist as an NC Marker and in Cancer and NC-Derived Stem Cells

Other Basic Helix-Loop-Helix Genes: Usf1, Usf 2, Tcfe3, Mnt, Olig3

4. ETS Genes

Ets1 and Ets2

Elk1 and Elk4

Etv1, Etv4, and Etv5

Erg

Fli1

Ets Translocations

5. Fox Genes

FoxC

FoxD

Foxd3 in Neural Crest Progenitor Cells

NC Induction and Regulation of Foxd3

Foxd3 Suppresses the Melanocyte Lineage

FoxE

FoxF

FoxJ

FoxN

FoxO

FoxS

6. Homeobox Genes

Alx

Barx1

Dlx1, Dlx2, Dlx3, Dlx5, Dlx6

Dlx1 and Dlx2

Dlx3

Dlx4

Dlx5

Dlx6

Emx

Gsx

Hlx

Hmx1

Irx

LBX1 and Lbx2

Msx1 and Msx2

Pitx2

Prrx1 and Prrx2

Runx1 and Runx2

Tlx

7. Hox Genes

Anterior Hox Genes (Hox1, Hox2, and Hox3 Paralogous Groups)

Hoxa1, Hoxb1, and Hoxd1

Hoxa2 and Hoxb2

Hoxa3, Hoxb3, and Hoxd3

Hox4 and Hox5 Paralogous Groups

Posterior Hox Genes (Hox6, Hox7, Hox8, and Hox9 Paralogous Groups)

8. Lim Genes

Lhx1 and Lhx7

Lims1, Jub, Pdlim5, Lmo4

9. Pax Genes

Pax3

Pax3 in Early Neural Crest Development and Migration

Pax3 in Neural and Glial Lineages

Pax3 in the Cardiac Neural Crest

Pax3 in the Melanocyte Lineage

Pax3 in Waardenburg Syndrome, Tumors and other Neurocristopathies

Pax3 Regulation and Interaction with Other Genes

Pax6

Pax7

Pax9

10. POU Domain Genes

Pou2f1/Oct1

Pou3f1/Oct6

Pou3f2/Brn2/Oct5

Pou4f1/Brn3

Pou5f1/Oct4

11. RAR/RXR Genes

RARa, RARb, and RARg

RXRa, RXRb, and RXRg

12. Smad Genes

Early NC

Cardiac NC

Neural, Glial, and Sympathoadrenal NC

Ocular NC

Dental NC

13. Sox Genes

Sox2

Sox4

Sox5

Sox8

Sox9

Sox9 during Neural Crest Specification

The Role of Sox9 in Chondrogenesis

Sox9 in NCSCs

Sox9 in the Melanocyte Lineage

Sox10

Sox10 Expression during NC Induction and in Migratory NCCs

Transcription Factors Upstream of Sox10 in NC Development

Regulation of Sox10

Sox10 Mutants as a Model for Waardenburg Syndrome 4

Sox10 in Glia of the PNS

Sox10 in Neural Derivatives

Sox10 in Melanocytes and Regulation of Mitf

Coregulation of Mitf Target Genes by Sox10

Additional Sox10 Regulation

Sox10 in Melanocyte Stem Cells

Sox10 in NCSCs and Cancer

14. Zinc Finger Genes

Gata2/3

Gata4

Gata6

Krox20

Krox20 in Schwann Cells

Krox20 in Patterning

Mecom/Evi1

Nczf

Prdm1 and Prdm2

Snail

Xenopus Snail

Zebrafish Snail

Chicken Snail

Mouse Snail

Human Snail

Slug

Avian Slug

Xenopus Slug and Upstream Regulation

Downstream of Xenopus Slug

Mouse Slug

Slug in Humans

Snail and Slug in Stem Cell Culture

Zeb1 and Zeb2

Zfp704

Zic1

Zic2

Zic3

Zic4 and Zic5

15. Other Miscellaneous Genes

Atf1

Cited2 and Cited4

Creb1

Ctbp1 and Ctbp2

Dawg

Mafb

Mediator Subunits Med12 and Med24

Mef2

Mrf2

Myb and Mybl2

Myocd, Mkl1, Mkl2

Nfatc3 and Nfatc4

Nfyb

Nuclear Receptors Nr2f1, Nr2f2, Nr5a1, Nr5a2

Rela (NFkB Subunit)

Srf

Immediate-Early Genes Sp1, Sp3, and Sp4

Stat3

Tcof1

Tead2

Tsc22d1

References

Author Biographies.

Notes:

Part of: Colloquium digital library of life sciences.

Series from website.

Title from PDF t.p. (viewed on April 7, 2010).

Includes bibliographical references.

Cited in:

Google scholar

Google book search

ISBN:

1-61504-049-8

OCLC:

699505580